Incidental Mutation 'IGL02232:Actr10'
ID 285787
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Actr10
Ensembl Gene ENSMUSG00000021076
Gene Name ARP10 actin-related protein 10
Synonyms Arp11
Accession Numbers
Essential gene? Probably essential (E-score: 0.963) question?
Stock # IGL02232
Quality Score
Status
Chromosome 12
Chromosomal Location 70984631-71011492 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 70990289 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 114 (E114K)
Ref Sequence ENSEMBL: ENSMUSP00000021479 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021479] [ENSMUST00000220582] [ENSMUST00000223549]
AlphaFold Q9QZB7
Predicted Effect probably benign
Transcript: ENSMUST00000021479
AA Change: E114K

PolyPhen 2 Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000021479
Gene: ENSMUSG00000021076
AA Change: E114K

DomainStartEndE-ValueType
ACTIN 13 394 3e-26 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000220582
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220770
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221165
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222291
Predicted Effect probably benign
Transcript: ENSMUST00000223549
AA Change: E67K

PolyPhen 2 Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810030O07Rik A G X: 12,530,764 (GRCm39) V199A possibly damaging Het
Aco1 T C 4: 40,175,996 (GRCm39) M210T probably damaging Het
Adam6b T C 12: 113,454,764 (GRCm39) M527T probably benign Het
Ahi1 C T 10: 20,857,274 (GRCm39) T623M probably damaging Het
Aldh8a1 T C 10: 21,271,545 (GRCm39) W424R probably damaging Het
Apeh A T 9: 107,969,071 (GRCm39) S299T probably benign Het
Bbs5 A C 2: 69,485,895 (GRCm39) I147L probably benign Het
Bmp2k T G 5: 97,179,109 (GRCm39) probably benign Het
C2cd6 A G 1: 59,101,651 (GRCm39) F336S probably damaging Het
Cd274 T A 19: 29,359,938 (GRCm39) L248M probably damaging Het
Chsy3 T A 18: 59,542,383 (GRCm39) M507K possibly damaging Het
Clip2 T C 5: 134,531,984 (GRCm39) N572S probably damaging Het
Commd9 A G 2: 101,731,324 (GRCm39) T170A probably benign Het
Cpt1c G A 7: 44,609,580 (GRCm39) S674L probably damaging Het
Dhx33 C A 11: 70,878,030 (GRCm39) R671L probably damaging Het
Dnah5 G A 15: 28,299,386 (GRCm39) E1583K probably damaging Het
Eed G T 7: 89,621,493 (GRCm39) N51K probably damaging Het
Efcab14 A G 4: 115,617,261 (GRCm39) probably benign Het
Ephb2 A C 4: 136,384,762 (GRCm39) M884R probably damaging Het
Foxn2 G T 17: 88,770,479 (GRCm39) A109S probably benign Het
Fut1 A T 7: 45,268,871 (GRCm39) D220V probably damaging Het
Gm6468 C T 5: 95,429,066 (GRCm39) noncoding transcript Het
Gm7964 A T 7: 83,405,515 (GRCm39) noncoding transcript Het
Gm9772 C T 17: 22,226,031 (GRCm39) probably benign Het
Golph3 G T 15: 12,349,578 (GRCm39) M199I probably benign Het
Itpr1 A G 6: 108,394,884 (GRCm39) N1666D probably damaging Het
Itprid1 A G 6: 55,944,922 (GRCm39) T548A unknown Het
Kif12 C T 4: 63,084,732 (GRCm39) E529K probably benign Het
Lpp C T 16: 24,580,895 (GRCm39) R204W probably damaging Het
Lrrc52 T A 1: 167,293,949 (GRCm39) N112I probably damaging Het
Msi1 T A 5: 115,579,506 (GRCm39) probably null Het
Nasp T G 4: 116,461,997 (GRCm39) E170A probably damaging Het
Necab2 T A 8: 120,189,391 (GRCm39) V187E probably damaging Het
Obscn T C 11: 58,929,804 (GRCm39) E5790G probably damaging Het
Or7e176 A T 9: 20,171,511 (GRCm39) D125V probably damaging Het
Or9a7 A G 6: 40,520,980 (GRCm39) L311P probably damaging Het
Pard3b C T 1: 62,205,541 (GRCm39) T445I probably damaging Het
Pcdh10 A G 3: 45,335,377 (GRCm39) I564V probably benign Het
Pcdhb22 T A 18: 37,653,602 (GRCm39) L690Q probably damaging Het
Pemt T A 11: 59,867,680 (GRCm39) T115S probably damaging Het
Plcl2 A G 17: 50,913,669 (GRCm39) N226S possibly damaging Het
Ppp6r1 A G 7: 4,636,341 (GRCm39) S750P probably damaging Het
Prtg T C 9: 72,758,771 (GRCm39) V375A probably damaging Het
Psd3 A C 8: 68,356,797 (GRCm39) M673R probably damaging Het
Ptprt T C 2: 161,372,437 (GRCm39) I1392V probably damaging Het
Rlf G A 4: 121,039,811 (GRCm39) T200I probably benign Het
Robo1 G A 16: 72,768,872 (GRCm39) G479D possibly damaging Het
Rpe65 A G 3: 159,309,988 (GRCm39) D87G possibly damaging Het
Sema3g T C 14: 30,943,181 (GRCm39) V148A probably damaging Het
Sgms2 G A 3: 131,116,833 (GRCm39) P341S probably benign Het
Skint7 A T 4: 111,839,225 (GRCm39) Q173L possibly damaging Het
Slc2a9 G A 5: 38,594,013 (GRCm39) A150V probably benign Het
Slc35c2 A G 2: 165,124,801 (GRCm39) L58P probably damaging Het
Slc7a6 G A 8: 106,923,206 (GRCm39) C495Y possibly damaging Het
Smurf1 G A 5: 144,823,248 (GRCm39) P458L probably damaging Het
Spag1 C T 15: 36,221,710 (GRCm39) T601I probably benign Het
Spink8 A T 9: 109,649,665 (GRCm39) Q49L possibly damaging Het
Spout1 A T 2: 30,065,266 (GRCm39) Y284N probably damaging Het
Srrm1 A T 4: 135,080,427 (GRCm39) M1K probably null Het
Stxbp5l A G 16: 37,150,257 (GRCm39) L116P probably damaging Het
Tlr9 T C 9: 106,102,136 (GRCm39) F476L probably damaging Het
Tmem41b A G 7: 109,577,960 (GRCm39) V108A probably damaging Het
Tra2b A G 16: 22,067,790 (GRCm39) probably benign Het
Trio G T 15: 27,902,647 (GRCm39) H271Q probably benign Het
Ttn A G 2: 76,723,263 (GRCm39) probably benign Het
Usp51 A T X: 151,791,669 (GRCm39) H421L probably damaging Het
Vmn2r29 A T 7: 7,244,810 (GRCm39) W355R probably damaging Het
Vpreb1a T C 16: 16,686,603 (GRCm39) N96D possibly damaging Het
Zfp318 C T 17: 46,707,736 (GRCm39) R265* probably null Het
Zp3r C A 1: 130,524,404 (GRCm39) C213F probably damaging Het
Other mutations in Actr10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02084:Actr10 APN 12 71,001,423 (GRCm39) missense probably damaging 1.00
IGL02628:Actr10 APN 12 71,001,430 (GRCm39) critical splice donor site probably null
IGL03202:Actr10 APN 12 70,987,605 (GRCm39) missense probably damaging 0.99
IGL03266:Actr10 APN 12 71,003,440 (GRCm39) missense probably benign 0.00
R0505:Actr10 UTSW 12 71,006,738 (GRCm39) missense probably damaging 1.00
R1734:Actr10 UTSW 12 71,008,770 (GRCm39) missense probably benign 0.23
R1919:Actr10 UTSW 12 70,989,104 (GRCm39) missense probably benign 0.00
R2151:Actr10 UTSW 12 70,987,575 (GRCm39) nonsense probably null
R2201:Actr10 UTSW 12 71,006,795 (GRCm39) missense probably damaging 0.97
R4259:Actr10 UTSW 12 70,999,759 (GRCm39) missense probably benign 0.02
R4261:Actr10 UTSW 12 70,999,759 (GRCm39) missense probably benign 0.02
R5138:Actr10 UTSW 12 71,008,653 (GRCm39) missense probably damaging 1.00
R5326:Actr10 UTSW 12 71,001,430 (GRCm39) unclassified probably benign
R5542:Actr10 UTSW 12 71,001,430 (GRCm39) unclassified probably benign
R6248:Actr10 UTSW 12 70,999,733 (GRCm39) missense probably benign 0.00
R6882:Actr10 UTSW 12 71,003,125 (GRCm39) missense probably benign 0.00
R7102:Actr10 UTSW 12 70,999,805 (GRCm39) critical splice donor site probably null
R7758:Actr10 UTSW 12 70,989,100 (GRCm39) missense probably damaging 1.00
R7800:Actr10 UTSW 12 70,990,283 (GRCm39) missense probably benign 0.26
R8766:Actr10 UTSW 12 71,001,430 (GRCm39) critical splice donor site probably null
R8850:Actr10 UTSW 12 70,989,032 (GRCm39) critical splice acceptor site probably null
R9011:Actr10 UTSW 12 70,999,734 (GRCm39) missense probably benign 0.01
R9068:Actr10 UTSW 12 70,989,073 (GRCm39) missense probably damaging 1.00
R9229:Actr10 UTSW 12 70,990,259 (GRCm39) missense probably damaging 1.00
R9452:Actr10 UTSW 12 71,006,818 (GRCm39) critical splice donor site probably null
X0012:Actr10 UTSW 12 70,987,639 (GRCm39) missense probably benign 0.04
X0027:Actr10 UTSW 12 71,006,733 (GRCm39) missense possibly damaging 0.94
Z1176:Actr10 UTSW 12 71,008,803 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16