Incidental Mutation 'IGL02233:Mup3'
ID285795
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mup3
Ensembl Gene ENSMUSG00000066154
Gene Namemajor urinary protein 3
SynonymsMup-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.052) question?
Stock #IGL02233
Quality Score
Status
Chromosome4
Chromosomal Location62083476-62087342 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 62084779 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 170 (I170T)
Ref Sequence ENSEMBL: ENSMUSP00000103112 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084531] [ENSMUST00000107472] [ENSMUST00000107488]
Predicted Effect probably damaging
Transcript: ENSMUST00000084531
AA Change: I170T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000081579
Gene: ENSMUSG00000066154
AA Change: I170T

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:Lipocalin 38 177 2.2e-37 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000107472
AA Change: I170T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000103096
Gene: ENSMUSG00000066154
AA Change: I170T

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:Lipocalin 38 177 2.2e-37 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000107488
AA Change: I170T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000103112
Gene: ENSMUSG00000066154
AA Change: I170T

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:Lipocalin 38 177 2.2e-37 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134190
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca5 G A 11: 110,274,344 Q1581* probably null Het
Abcc10 A T 17: 46,324,159 probably null Het
Adam25 A G 8: 40,755,386 Y563C probably damaging Het
Cnr2 T A 4: 135,917,211 I200N possibly damaging Het
Col5a2 T C 1: 45,383,587 probably null Het
Cpa2 T C 6: 30,557,667 probably benign Het
Dis3l2 T C 1: 86,990,231 V534A probably damaging Het
Dlg2 A T 7: 92,444,538 D845V probably damaging Het
Dnah8 T C 17: 30,706,513 probably null Het
Ephb4 T A 5: 137,354,501 Y115* probably null Het
Evc2 A G 5: 37,378,337 Y452C probably damaging Het
Fbn1 A G 2: 125,321,610 probably benign Het
Gm5134 A T 10: 76,008,500 probably null Het
Gpr157 A G 4: 150,101,727 T249A possibly damaging Het
Hoxc6 A G 15: 103,009,876 T91A probably benign Het
Lin9 C A 1: 180,689,300 A535E probably damaging Het
Muc1 G A 3: 89,231,628 V515I probably benign Het
Myo1e T C 9: 70,383,799 probably benign Het
Olfr411 A G 11: 74,347,428 V52A possibly damaging Het
Olfr914 A G 9: 38,607,242 Y259C probably damaging Het
Pde4d T C 13: 109,740,550 S202P probably damaging Het
Pomt2 A G 12: 87,111,411 V676A probably benign Het
Rasl10a C A 11: 5,058,333 L10M probably damaging Het
Rilp T C 11: 75,512,712 Y327H probably damaging Het
Sec23ip A G 7: 128,779,179 S957G probably damaging Het
Srbd1 T C 17: 86,098,622 probably null Het
Thsd7a T C 6: 12,555,258 H209R probably benign Het
Trav14-3 T C 14: 53,763,186 probably benign Het
Vipr2 A G 12: 116,094,736 N91S probably damaging Het
Zfp318 C T 17: 46,396,810 R265* probably null Het
Other mutations in Mup3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01383:Mup3 APN 4 62085959 missense probably damaging 0.98
IGL03088:Mup3 APN 4 62086842 missense probably damaging 0.99
R0432:Mup3 UTSW 4 62085282 missense probably benign 0.13
R0619:Mup3 UTSW 4 62085961 missense probably benign 0.02
R0884:Mup3 UTSW 4 62087174 missense possibly damaging 0.68
R5568:Mup3 UTSW 4 62084572 missense possibly damaging 0.93
R5849:Mup3 UTSW 4 62086935 critical splice acceptor site probably null
R5909:Mup3 UTSW 4 62086007 missense probably benign 0.01
R7851:Mup3 UTSW 4 62085257 missense possibly damaging 0.65
Z1088:Mup3 UTSW 4 62087189 missense unknown
Posted On2015-04-16