Incidental Mutation 'IGL02233:Gpr157'
ID285802
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr157
Ensembl Gene ENSMUSG00000047875
Gene NameG protein-coupled receptor 157
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02233
Quality Score
Status
Chromosome4
Chromosomal Location150087365-150105927 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 150101727 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 249 (T249A)
Ref Sequence ENSEMBL: ENSMUSP00000092020 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094451]
Predicted Effect possibly damaging
Transcript: ENSMUST00000094451
AA Change: T249A

PolyPhen 2 Score 0.633 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000092020
Gene: ENSMUSG00000047875
AA Change: T249A

DomainStartEndE-ValueType
Pfam:Dicty_CAR 11 205 4.1e-12 PFAM
Pfam:Frizzled 14 250 2e-8 PFAM
Pfam:7tm_2 14 274 2e-15 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca5 G A 11: 110,274,344 Q1581* probably null Het
Abcc10 A T 17: 46,324,159 probably null Het
Adam25 A G 8: 40,755,386 Y563C probably damaging Het
Cnr2 T A 4: 135,917,211 I200N possibly damaging Het
Col5a2 T C 1: 45,383,587 probably null Het
Cpa2 T C 6: 30,557,667 probably benign Het
Dis3l2 T C 1: 86,990,231 V534A probably damaging Het
Dlg2 A T 7: 92,444,538 D845V probably damaging Het
Dnah8 T C 17: 30,706,513 probably null Het
Ephb4 T A 5: 137,354,501 Y115* probably null Het
Evc2 A G 5: 37,378,337 Y452C probably damaging Het
Fbn1 A G 2: 125,321,610 probably benign Het
Gm5134 A T 10: 76,008,500 probably null Het
Hoxc6 A G 15: 103,009,876 T91A probably benign Het
Lin9 C A 1: 180,689,300 A535E probably damaging Het
Muc1 G A 3: 89,231,628 V515I probably benign Het
Mup3 A G 4: 62,084,779 I170T probably damaging Het
Myo1e T C 9: 70,383,799 probably benign Het
Olfr411 A G 11: 74,347,428 V52A possibly damaging Het
Olfr914 A G 9: 38,607,242 Y259C probably damaging Het
Pde4d T C 13: 109,740,550 S202P probably damaging Het
Pomt2 A G 12: 87,111,411 V676A probably benign Het
Rasl10a C A 11: 5,058,333 L10M probably damaging Het
Rilp T C 11: 75,512,712 Y327H probably damaging Het
Sec23ip A G 7: 128,779,179 S957G probably damaging Het
Srbd1 T C 17: 86,098,622 probably null Het
Thsd7a T C 6: 12,555,258 H209R probably benign Het
Trav14-3 T C 14: 53,763,186 probably benign Het
Vipr2 A G 12: 116,094,736 N91S probably damaging Het
Zfp318 C T 17: 46,396,810 R265* probably null Het
Other mutations in Gpr157
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01611:Gpr157 APN 4 150101637 missense possibly damaging 0.59
R2912:Gpr157 UTSW 4 150098765 missense probably benign 0.08
R2913:Gpr157 UTSW 4 150098765 missense probably benign 0.08
R4721:Gpr157 UTSW 4 150098963 missense probably benign 0.01
R4840:Gpr157 UTSW 4 150102366 missense probably benign 0.00
R5089:Gpr157 UTSW 4 150102293 missense possibly damaging 0.89
R5322:Gpr157 UTSW 4 150098852 missense probably benign
R5445:Gpr157 UTSW 4 150102368 missense probably benign 0.00
R6210:Gpr157 UTSW 4 150101598 missense probably damaging 1.00
R7252:Gpr157 UTSW 4 150098874 missense probably benign 0.01
R8246:Gpr157 UTSW 4 150102296 missense possibly damaging 0.80
R8274:Gpr157 UTSW 4 150088043 missense probably damaging 1.00
Posted On2015-04-16