Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00953:Or2t46'

28583

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or2t46

Ensembl Gene

ENSMUSG00000060765

Gene Name

olfactory receptor family 2 subfamily T member 46

Synonyms

MOR275-11_p, Olfr325, GA_x6K02T2NKPP-844642-843680, MOR275-5

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

IGL00953

Quality Score

Status

Chromosome

Chromosomal Location

58471663-58472703 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 58472636 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 322 (V322A)

Ref Sequence

ENSEMBL: ENSMUSP00000145386 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169428] [ENSMUST00000203418]

AlphaFold

Q5NCD2

Predicted Effect

probably benign
Transcript: ENSMUST00000169428
AA Change: V322A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000131257
Gene: ENSMUSG00000060765
AA Change: V322A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	312	2.3e-46	PFAM
Pfam:7TM_GPCR_Srsx	39	290	1.4e-6	PFAM
Pfam:7tm_1	45	294	1.6e-27	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000203418
AA Change: V322A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000145386
Gene: ENSMUSG00000060765
AA Change: V322A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	130	7.6e-14	PFAM
Pfam:7TM_GPCR_Srsx	36	130	1.1e-4	PFAM
Pfam:7tm_1	45	130	2.6e-16	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aatk	T	C	11: 119,902,047 (GRCm39)	E726G	probably benign	Het
Cdyl2	T	A	8: 117,321,928 (GRCm39)		probably benign	Het
Cep41	T	C	6: 30,660,966 (GRCm39)	T109A	probably benign	Het
Clca3b	C	T	3: 144,552,972 (GRCm39)	W84*	probably null	Het
Cyp27b1	A	G	10: 126,885,551 (GRCm39)	D130G	probably benign	Het
Cyp2f2	T	C	7: 26,829,242 (GRCm39)	V249A	possibly damaging	Het
Cyth3	G	A	5: 143,692,920 (GRCm39)		probably null	Het
Dnah8	G	T	17: 30,925,431 (GRCm39)	E1289*	probably null	Het
Fam171a1	A	T	2: 3,179,327 (GRCm39)	D51V	possibly damaging	Het
Farp2	A	G	1: 93,488,896 (GRCm39)	R107G	possibly damaging	Het
Gemin6	T	C	17: 80,535,294 (GRCm39)	F85L	possibly damaging	Het
Hivep3	A	C	4: 119,955,571 (GRCm39)	T1296P	probably damaging	Het
Hnrnpm	C	A	17: 33,868,876 (GRCm39)	R517L	probably damaging	Het
Htt	T	A	5: 34,976,021 (GRCm39)	S670T	probably benign	Het
Klhl24	A	T	16: 19,941,717 (GRCm39)	N555I	possibly damaging	Het
Limd1	T	A	9: 123,308,948 (GRCm39)	S216T	probably benign	Het
Lmf2	A	T	15: 89,238,102 (GRCm39)	I234N	probably damaging	Het
Mrpl4	C	A	9: 20,919,863 (GRCm39)	D271E	probably benign	Het
Mydgf	C	T	17: 56,486,407 (GRCm39)	G75R	probably damaging	Het
Nat1	A	G	8: 67,943,630 (GRCm39)	D5G	possibly damaging	Het
Or5h22	A	T	16: 58,895,052 (GRCm39)	Y130*	probably null	Het
Or5k15	A	C	16: 58,710,048 (GRCm39)	H178Q	probably damaging	Het
Pla2g4c	T	A	7: 13,077,951 (GRCm39)	M363K	probably benign	Het
Prex1	A	G	2: 166,480,329 (GRCm39)	F137S	probably damaging	Het
Rbm12b1	A	G	4: 12,146,038 (GRCm39)	D670G	probably damaging	Het
Rrp12	C	A	19: 41,860,231 (GRCm39)	M997I	possibly damaging	Het
Scn3a	A	G	2: 65,327,736 (GRCm39)	V918A	probably benign	Het
Slc35g2	A	G	9: 100,434,516 (GRCm39)	V385A	probably damaging	Het
Slit1	A	T	19: 41,590,739 (GRCm39)	I1311N	probably damaging	Het
Ube2j2	C	T	4: 156,030,834 (GRCm39)		probably benign	Het
Ucp2	A	G	7: 100,147,629 (GRCm39)	T203A	probably benign	Het
Upk1b	C	T	16: 38,600,347 (GRCm39)	G211D	possibly damaging	Het
Vmn1r220	A	T	13: 23,367,935 (GRCm39)	F254I	probably benign	Het
Zcchc4	T	C	5: 52,965,638 (GRCm39)	F314S	probably damaging	Het

Other mutations in Or2t46

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01922:Or2t46	APN	11	58,471,899 (GRCm39)	missense	probably benign	0.01
IGL02440:Or2t46	APN	11	58,472,035 (GRCm39)	missense	probably damaging	1.00
IGL02456:Or2t46	APN	11	58,472,024 (GRCm39)	missense	possibly damaging	0.48
IGL03088:Or2t46	APN	11	58,472,653 (GRCm39)	utr 3 prime	probably benign
IGL03328:Or2t46	APN	11	58,472,539 (GRCm39)	missense	probably damaging	1.00
R0604:Or2t46	UTSW	11	58,472,174 (GRCm39)	missense	probably damaging	0.99
R1698:Or2t46	UTSW	11	58,472,077 (GRCm39)	missense	probably damaging	1.00
R2473:Or2t46	UTSW	11	58,472,401 (GRCm39)	missense	probably damaging	1.00
R2888:Or2t46	UTSW	11	58,471,988 (GRCm39)	missense	possibly damaging	0.96
R4133:Or2t46	UTSW	11	58,471,901 (GRCm39)	missense	probably damaging	0.97
R4710:Or2t46	UTSW	11	58,472,548 (GRCm39)	missense	probably damaging	1.00
R4715:Or2t46	UTSW	11	58,472,255 (GRCm39)	missense	probably damaging	1.00
R4898:Or2t46	UTSW	11	58,472,546 (GRCm39)	missense	probably damaging	1.00
R4939:Or2t46	UTSW	11	58,472,037 (GRCm39)	missense	probably damaging	1.00
R4977:Or2t46	UTSW	11	58,472,455 (GRCm39)	missense	possibly damaging	0.57
R5389:Or2t46	UTSW	11	58,471,825 (GRCm39)	missense	possibly damaging	0.78
R5393:Or2t46	UTSW	11	58,471,825 (GRCm39)	missense	possibly damaging	0.78
R6137:Or2t46	UTSW	11	58,471,894 (GRCm39)	missense	probably benign
R6302:Or2t46	UTSW	11	58,472,464 (GRCm39)	missense	probably benign
R6655:Or2t46	UTSW	11	58,472,036 (GRCm39)	missense	probably damaging	1.00
R6927:Or2t46	UTSW	11	58,472,491 (GRCm39)	missense	possibly damaging	0.81
R7451:Or2t46	UTSW	11	58,472,516 (GRCm39)	missense	probably damaging	1.00
R7494:Or2t46	UTSW	11	58,472,038 (GRCm39)	missense	probably damaging	0.97
R7626:Or2t46	UTSW	11	58,471,999 (GRCm39)	missense	probably damaging	0.97
R7724:Or2t46	UTSW	11	58,472,208 (GRCm39)	missense	probably benign	0.01
R7874:Or2t46	UTSW	11	58,472,573 (GRCm39)	missense	possibly damaging	0.93
R8217:Or2t46	UTSW	11	58,471,792 (GRCm39)	missense	probably benign	0.00
R8252:Or2t46	UTSW	11	58,471,958 (GRCm39)	missense	probably damaging	1.00
R8992:Or2t46	UTSW	11	58,471,738 (GRCm39)	missense	probably benign	0.00
R9376:Or2t46	UTSW	11	58,472,636 (GRCm39)	missense	probably benign
R9439:Or2t46	UTSW	11	58,472,104 (GRCm39)	missense	probably benign	0.38
Z1177:Or2t46	UTSW	11	58,472,137 (GRCm39)	missense	probably damaging	1.00
Z1186:Or2t46	UTSW	11	58,472,122 (GRCm39)	missense	probably benign
Z1186:Or2t46	UTSW	11	58,472,483 (GRCm39)	missense	probably benign
Z1186:Or2t46	UTSW	11	58,471,750 (GRCm39)	missense	probably benign	0.00
Z1186:Or2t46	UTSW	11	58,471,757 (GRCm39)	missense	probably benign
Z1186:Or2t46	UTSW	11	58,471,828 (GRCm39)	missense	probably benign
Z1187:Or2t46	UTSW	11	58,471,828 (GRCm39)	missense	probably benign
Z1187:Or2t46	UTSW	11	58,471,757 (GRCm39)	missense	probably benign
Z1187:Or2t46	UTSW	11	58,471,750 (GRCm39)	missense	probably benign	0.00
Z1187:Or2t46	UTSW	11	58,472,483 (GRCm39)	missense	probably benign
Z1187:Or2t46	UTSW	11	58,472,122 (GRCm39)	missense	probably benign
Z1188:Or2t46	UTSW	11	58,471,828 (GRCm39)	missense	probably benign
Z1188:Or2t46	UTSW	11	58,471,757 (GRCm39)	missense	probably benign
Z1188:Or2t46	UTSW	11	58,471,750 (GRCm39)	missense	probably benign	0.00
Z1188:Or2t46	UTSW	11	58,472,483 (GRCm39)	missense	probably benign
Z1188:Or2t46	UTSW	11	58,472,122 (GRCm39)	missense	probably benign
Z1189:Or2t46	UTSW	11	58,472,122 (GRCm39)	missense	probably benign
Z1189:Or2t46	UTSW	11	58,471,757 (GRCm39)	missense	probably benign
Z1189:Or2t46	UTSW	11	58,471,750 (GRCm39)	missense	probably benign	0.00
Z1189:Or2t46	UTSW	11	58,472,483 (GRCm39)	missense	probably benign
Z1190:Or2t46	UTSW	11	58,471,828 (GRCm39)	missense	probably benign
Z1190:Or2t46	UTSW	11	58,471,757 (GRCm39)	missense	probably benign
Z1190:Or2t46	UTSW	11	58,471,750 (GRCm39)	missense	probably benign	0.00
Z1190:Or2t46	UTSW	11	58,472,483 (GRCm39)	missense	probably benign
Z1190:Or2t46	UTSW	11	58,472,122 (GRCm39)	missense	probably benign
Z1191:Or2t46	UTSW	11	58,471,828 (GRCm39)	missense	probably benign
Z1191:Or2t46	UTSW	11	58,471,757 (GRCm39)	missense	probably benign
Z1191:Or2t46	UTSW	11	58,471,750 (GRCm39)	missense	probably benign	0.00
Z1191:Or2t46	UTSW	11	58,472,483 (GRCm39)	missense	probably benign
Z1191:Or2t46	UTSW	11	58,472,122 (GRCm39)	missense	probably benign
Z1192:Or2t46	UTSW	11	58,472,122 (GRCm39)	missense	probably benign
Z1192:Or2t46	UTSW	11	58,471,757 (GRCm39)	missense	probably benign
Z1192:Or2t46	UTSW	11	58,471,750 (GRCm39)	missense	probably benign	0.00
Z1192:Or2t46	UTSW	11	58,472,483 (GRCm39)	missense	probably benign

Posted On

2013-04-17