Incidental Mutation 'IGL02234:Htr1f'
| ID |
285842 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Htr1f
|
| Ensembl Gene |
ENSMUSG00000050783 |
| Gene Name |
5-hydroxytryptamine (serotonin) receptor 1F |
| Synonyms |
Htr1eb |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02234
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
16 |
| Chromosomal Location |
64745092-64926147 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 64746430 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Serine
at position 287
(R287S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000063136
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000063076]
|
| AlphaFold |
Q02284 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000063076
AA Change: R287S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000063136
Gene: ENSMUSG00000050783
AA Change: R287S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
32 |
230 |
4.8e-7 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
34 |
362 |
2.4e-10 |
PFAM |
|
Pfam:7tm_1
|
40 |
347 |
4.1e-74 |
PFAM |
|
Pfam:7TM_GPCR_Srv
|
54 |
249 |
5.2e-7 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for disruptions in this gene display decreased temperature sensitivity and physiological abnormalities in nerve fibers. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A2m |
C |
T |
6: 121,645,179 (GRCm39) |
T1010M |
possibly damaging |
Het |
| Atr |
A |
G |
9: 95,829,303 (GRCm39) |
|
probably benign |
Het |
| Cdc42bpa |
A |
T |
1: 179,978,756 (GRCm39) |
K1585* |
probably null |
Het |
| Cdh19 |
T |
C |
1: 110,859,956 (GRCm39) |
D175G |
probably damaging |
Het |
| Celsr3 |
G |
T |
9: 108,707,159 (GRCm39) |
R1214L |
probably benign |
Het |
| Chchd1 |
T |
C |
14: 20,753,478 (GRCm39) |
|
probably null |
Het |
| Col4a1 |
T |
C |
8: 11,266,713 (GRCm39) |
K1165E |
probably damaging |
Het |
| Col6a4 |
A |
G |
9: 105,890,631 (GRCm39) |
F1888L |
possibly damaging |
Het |
| Csmd3 |
C |
A |
15: 47,811,512 (GRCm39) |
R1193L |
probably damaging |
Het |
| Cyp2d11 |
T |
A |
15: 82,274,340 (GRCm39) |
H347L |
probably benign |
Het |
| Cyp4f13 |
A |
G |
17: 33,143,748 (GRCm39) |
|
probably benign |
Het |
| Dop1b |
T |
C |
16: 93,549,039 (GRCm39) |
V193A |
probably benign |
Het |
| Dus4l |
T |
C |
12: 31,691,495 (GRCm39) |
|
probably benign |
Het |
| Epc1 |
G |
A |
18: 6,439,938 (GRCm39) |
H79Y |
probably damaging |
Het |
| Gm12588 |
T |
A |
11: 121,799,151 (GRCm39) |
|
|
Het |
| Gpr107 |
T |
C |
2: 31,067,845 (GRCm39) |
Y222H |
probably damaging |
Het |
| Gzmn |
C |
T |
14: 56,406,464 (GRCm39) |
|
probably null |
Het |
| Helq |
A |
G |
5: 100,944,336 (GRCm39) |
I258T |
possibly damaging |
Het |
| Hsp90ab1 |
T |
C |
17: 45,880,661 (GRCm39) |
K137R |
probably benign |
Het |
| Il20ra |
A |
C |
10: 19,625,018 (GRCm39) |
D99A |
probably damaging |
Het |
| Lpp |
C |
T |
16: 24,580,895 (GRCm39) |
R204W |
probably damaging |
Het |
| Mboat7 |
A |
G |
7: 3,694,350 (GRCm39) |
Y34H |
probably damaging |
Het |
| Mid2 |
T |
C |
X: 139,664,418 (GRCm39) |
S646P |
probably damaging |
Het |
| Msh6 |
T |
C |
17: 88,294,229 (GRCm39) |
S995P |
probably damaging |
Het |
| Mtmr10 |
A |
G |
7: 63,949,350 (GRCm39) |
I108V |
probably benign |
Het |
| Muc6 |
G |
A |
7: 141,226,842 (GRCm39) |
T1395M |
probably benign |
Het |
| Nlrp4f |
A |
G |
13: 65,342,302 (GRCm39) |
F448L |
probably damaging |
Het |
| Odc1 |
C |
A |
12: 17,598,621 (GRCm39) |
D220E |
possibly damaging |
Het |
| Or8k33 |
T |
C |
2: 86,383,610 (GRCm39) |
N286S |
probably damaging |
Het |
| Pax7 |
A |
G |
4: 139,555,901 (GRCm39) |
I189T |
probably damaging |
Het |
| Pcdh12 |
T |
A |
18: 38,416,588 (GRCm39) |
H179L |
probably damaging |
Het |
| Pcdh15 |
A |
T |
10: 74,467,694 (GRCm39) |
M1836L |
probably benign |
Het |
| Psmc5 |
T |
C |
11: 106,153,836 (GRCm39) |
V390A |
probably benign |
Het |
| Ror2 |
C |
T |
13: 53,264,764 (GRCm39) |
S764N |
probably damaging |
Het |
| Rpgrip1 |
A |
G |
14: 52,368,766 (GRCm39) |
|
probably benign |
Het |
| Sema5a |
C |
T |
15: 32,679,318 (GRCm39) |
R866C |
probably damaging |
Het |
| Stox2 |
A |
G |
8: 47,646,647 (GRCm39) |
F271S |
probably damaging |
Het |
| Tpgs2 |
T |
C |
18: 25,282,301 (GRCm39) |
|
probably null |
Het |
| Ttll8 |
T |
A |
15: 88,798,252 (GRCm39) |
I828F |
possibly damaging |
Het |
| Vmn1r7 |
T |
C |
6: 57,001,537 (GRCm39) |
Y241C |
probably damaging |
Het |
| Zfp318 |
C |
T |
17: 46,707,736 (GRCm39) |
R265* |
probably null |
Het |
|
| Other mutations in Htr1f |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00896:Htr1f
|
APN |
16 |
64,746,469 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01134:Htr1f
|
APN |
16 |
64,746,501 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01455:Htr1f
|
APN |
16 |
64,746,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01580:Htr1f
|
APN |
16 |
64,746,198 (GRCm39) |
nonsense |
probably null |
|
|
IGL01865:Htr1f
|
APN |
16 |
64,746,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02027:Htr1f
|
APN |
16 |
64,746,684 (GRCm39) |
nonsense |
probably null |
|
|
IGL02567:Htr1f
|
APN |
16 |
64,746,611 (GRCm39) |
missense |
probably benign |
0.45 |
|
R0035:Htr1f
|
UTSW |
16 |
64,746,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Htr1f
|
UTSW |
16 |
64,747,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Htr1f
|
UTSW |
16 |
64,747,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0132:Htr1f
|
UTSW |
16 |
64,747,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Htr1f
|
UTSW |
16 |
64,747,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0523:Htr1f
|
UTSW |
16 |
64,746,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0722:Htr1f
|
UTSW |
16 |
64,746,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2055:Htr1f
|
UTSW |
16 |
64,746,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3418:Htr1f
|
UTSW |
16 |
64,746,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4090:Htr1f
|
UTSW |
16 |
64,746,324 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4320:Htr1f
|
UTSW |
16 |
64,747,050 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5037:Htr1f
|
UTSW |
16 |
64,746,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6004:Htr1f
|
UTSW |
16 |
64,746,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7383:Htr1f
|
UTSW |
16 |
64,747,206 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7462:Htr1f
|
UTSW |
16 |
64,746,383 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7864:Htr1f
|
UTSW |
16 |
64,747,157 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8677:Htr1f
|
UTSW |
16 |
64,746,414 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8816:Htr1f
|
UTSW |
16 |
64,746,537 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8836:Htr1f
|
UTSW |
16 |
64,747,196 (GRCm39) |
missense |
probably benign |
|
|
R9106:Htr1f
|
UTSW |
16 |
64,746,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9155:Htr1f
|
UTSW |
16 |
64,746,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Htr1f
|
UTSW |
16 |
64,746,825 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9244:Htr1f
|
UTSW |
16 |
64,746,857 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9430:Htr1f
|
UTSW |
16 |
64,746,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Htr1f
|
UTSW |
16 |
64,747,237 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Htr1f
|
UTSW |
16 |
64,746,440 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation