Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02234:Gzmn'

285864

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gzmn

Ensembl Gene

ENSMUSG00000015443

Gene Name

granzyme N

Synonyms

GrN

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

IGL02234

Quality Score

Status

Chromosome

Chromosomal Location

56403254-56412056 bp(-) (GRCm39)

Type of Mutation

splice site (5 bp from exon)

DNA Base Change (assembly)

C to T at 56406464 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000153137 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000015587] [ENSMUST00000225535]

AlphaFold

Q920S1

Predicted Effect

probably null
Transcript: ENSMUST00000015587

SMART Domains

Protein: ENSMUSP00000015587
Gene: ENSMUSG00000015443

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Tryp_SPc	20	241	5.89e-72	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223614

Predicted Effect

probably null
Transcript: ENSMUST00000225535

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	C	T	6: 121,645,179 (GRCm39)	T1010M	possibly damaging	Het
Atr	A	G	9: 95,829,303 (GRCm39)		probably benign	Het
Cdc42bpa	A	T	1: 179,978,756 (GRCm39)	K1585*	probably null	Het
Cdh19	T	C	1: 110,859,956 (GRCm39)	D175G	probably damaging	Het
Celsr3	G	T	9: 108,707,159 (GRCm39)	R1214L	probably benign	Het
Chchd1	T	C	14: 20,753,478 (GRCm39)		probably null	Het
Col4a1	T	C	8: 11,266,713 (GRCm39)	K1165E	probably damaging	Het
Col6a4	A	G	9: 105,890,631 (GRCm39)	F1888L	possibly damaging	Het
Csmd3	C	A	15: 47,811,512 (GRCm39)	R1193L	probably damaging	Het
Cyp2d11	T	A	15: 82,274,340 (GRCm39)	H347L	probably benign	Het
Cyp4f13	A	G	17: 33,143,748 (GRCm39)		probably benign	Het
Dop1b	T	C	16: 93,549,039 (GRCm39)	V193A	probably benign	Het
Dus4l	T	C	12: 31,691,495 (GRCm39)		probably benign	Het
Epc1	G	A	18: 6,439,938 (GRCm39)	H79Y	probably damaging	Het
Gm12588	T	A	11: 121,799,151 (GRCm39)			Het
Gpr107	T	C	2: 31,067,845 (GRCm39)	Y222H	probably damaging	Het
Helq	A	G	5: 100,944,336 (GRCm39)	I258T	possibly damaging	Het
Hsp90ab1	T	C	17: 45,880,661 (GRCm39)	K137R	probably benign	Het
Htr1f	T	A	16: 64,746,430 (GRCm39)	R287S	probably damaging	Het
Il20ra	A	C	10: 19,625,018 (GRCm39)	D99A	probably damaging	Het
Lpp	C	T	16: 24,580,895 (GRCm39)	R204W	probably damaging	Het
Mboat7	A	G	7: 3,694,350 (GRCm39)	Y34H	probably damaging	Het
Mid2	T	C	X: 139,664,418 (GRCm39)	S646P	probably damaging	Het
Msh6	T	C	17: 88,294,229 (GRCm39)	S995P	probably damaging	Het
Mtmr10	A	G	7: 63,949,350 (GRCm39)	I108V	probably benign	Het
Muc6	G	A	7: 141,226,842 (GRCm39)	T1395M	probably benign	Het
Nlrp4f	A	G	13: 65,342,302 (GRCm39)	F448L	probably damaging	Het
Odc1	C	A	12: 17,598,621 (GRCm39)	D220E	possibly damaging	Het
Or8k33	T	C	2: 86,383,610 (GRCm39)	N286S	probably damaging	Het
Pax7	A	G	4: 139,555,901 (GRCm39)	I189T	probably damaging	Het
Pcdh12	T	A	18: 38,416,588 (GRCm39)	H179L	probably damaging	Het
Pcdh15	A	T	10: 74,467,694 (GRCm39)	M1836L	probably benign	Het
Psmc5	T	C	11: 106,153,836 (GRCm39)	V390A	probably benign	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Rpgrip1	A	G	14: 52,368,766 (GRCm39)		probably benign	Het
Sema5a	C	T	15: 32,679,318 (GRCm39)	R866C	probably damaging	Het
Stox2	A	G	8: 47,646,647 (GRCm39)	F271S	probably damaging	Het
Tpgs2	T	C	18: 25,282,301 (GRCm39)		probably null	Het
Ttll8	T	A	15: 88,798,252 (GRCm39)	I828F	possibly damaging	Het
Vmn1r7	T	C	6: 57,001,537 (GRCm39)	Y241C	probably damaging	Het
Zfp318	C	T	17: 46,707,736 (GRCm39)	R265*	probably null	Het

Other mutations in Gzmn

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00473:Gzmn	APN	14	56,404,436 (GRCm39)	missense	probably benign	0.06
IGL01638:Gzmn	APN	14	56,406,476 (GRCm39)	missense	probably benign	0.03
IGL02691:Gzmn	APN	14	56,404,370 (GRCm39)	missense	probably benign	0.10
R0022:Gzmn	UTSW	14	56,404,382 (GRCm39)	missense	probably damaging	1.00
R1589:Gzmn	UTSW	14	56,403,368 (GRCm39)	missense	probably benign	0.05
R3763:Gzmn	UTSW	14	56,404,361 (GRCm39)	missense	probably benign	0.08
R4153:Gzmn	UTSW	14	56,405,299 (GRCm39)	missense	probably damaging	1.00
R4170:Gzmn	UTSW	14	56,404,261 (GRCm39)	missense	possibly damaging	0.73
R4420:Gzmn	UTSW	14	56,403,463 (GRCm39)	missense	probably benign	0.03
R5215:Gzmn	UTSW	14	56,405,319 (GRCm39)	missense	probably damaging	1.00
R5307:Gzmn	UTSW	14	56,405,403 (GRCm39)	missense	probably damaging	0.99
R6727:Gzmn	UTSW	14	56,403,432 (GRCm39)	missense	probably damaging	0.99
R7644:Gzmn	UTSW	14	56,404,776 (GRCm39)	missense	probably damaging	1.00
R9701:Gzmn	UTSW	14	56,405,310 (GRCm39)	missense	probably benign	0.17
X0023:Gzmn	UTSW	14	56,404,807 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16