Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02236:Trav14-1'

285874

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trav14-1

Ensembl Gene

ENSMUSG00000076840

Gene Name

T cell receptor alpha variable 14-1

Synonyms

Gm5770

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

IGL02236

Quality Score

Status

Chromosome

Chromosomal Location

53791514-53792015 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 53791763 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 38 (S38T)

Ref Sequence

ENSEMBL: ENSMUSP00000143077 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000198297]

AlphaFold

A0A0G2JF94

Predicted Effect

possibly damaging
Transcript: ENSMUST00000198297
AA Change: S38T

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000143077
Gene: ENSMUSG00000076840
AA Change: S38T

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGv	46	120	2.6e-13	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Baz1b	T	C	5: 135,246,138 (GRCm39)	L529P	probably damaging	Het
Bdp1	A	T	13: 100,197,399 (GRCm39)	D995E	probably benign	Het
Cd22	T	C	7: 30,566,893 (GRCm39)	N607S	possibly damaging	Het
Ddx10	T	A	9: 53,146,682 (GRCm39)	D180V	probably damaging	Het
Dennd4c	T	C	4: 86,725,672 (GRCm39)	Y709H	possibly damaging	Het
Dhrs3	A	C	4: 144,620,133 (GRCm39)	I17L	probably benign	Het
Dnah8	A	T	17: 30,868,747 (GRCm39)	K394*	probably null	Het
Flnc	T	A	6: 29,454,375 (GRCm39)	I1896N	probably damaging	Het
Glipr1l2	A	G	10: 111,928,534 (GRCm39)	Y143C	probably damaging	Het
Lmo7	T	C	14: 102,163,524 (GRCm39)		probably benign	Het
Lpp	C	T	16: 24,580,895 (GRCm39)	R204W	probably damaging	Het
Mast3	A	G	8: 71,241,888 (GRCm39)	S98P	probably benign	Het
Myf5	A	G	10: 107,320,051 (GRCm39)	S200P	possibly damaging	Het
Or52r1b	T	G	7: 102,690,928 (GRCm39)	S76A	possibly damaging	Het
Pramel12	G	A	4: 143,143,512 (GRCm39)	V93I	probably benign	Het
Recql5	A	C	11: 115,784,856 (GRCm39)	S824A	probably benign	Het
Reg2	A	G	6: 78,383,188 (GRCm39)	E45G	probably damaging	Het
Rergl	T	C	6: 139,471,918 (GRCm39)	D77G	probably benign	Het
Rnf224	T	C	2: 25,126,260 (GRCm39)	D31G	probably damaging	Het
Sema4c	C	T	1: 36,592,166 (GRCm39)	S227N	probably damaging	Het
Sgsm2	C	T	11: 74,750,698 (GRCm39)	G439D	probably damaging	Het
Smap2	T	A	4: 120,832,587 (GRCm39)	M185L	probably benign	Het
Spty2d1	A	G	7: 46,647,360 (GRCm39)	V523A	probably benign	Het
Stk17b	C	A	1: 53,803,247 (GRCm39)	R184L	probably damaging	Het
Syt13	A	G	2: 92,771,210 (GRCm39)	D99G	probably damaging	Het
Ttn	T	C	2: 76,700,812 (GRCm39)		probably benign	Het
Usp17la	G	A	7: 104,510,353 (GRCm39)	W319*	probably null	Het
Vmn2r73	T	C	7: 85,521,902 (GRCm39)	T146A	probably benign	Het
Vwa3b	C	T	1: 37,193,132 (GRCm39)		probably benign	Het
Zfp13	A	T	17: 23,799,739 (GRCm39)		probably benign	Het
Zscan18	A	C	7: 12,503,251 (GRCm39)	D769E	probably benign	Het

Other mutations in Trav14-1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R5258:Trav14-1	UTSW	14	53,791,730 (GRCm39)	missense	probably benign	0.10
R6340:Trav14-1	UTSW	14	53,791,955 (GRCm39)	missense	probably damaging	1.00
R6987:Trav14-1	UTSW	14	53,791,916 (GRCm39)	nonsense	probably null
R8838:Trav14-1	UTSW	14	53,792,009 (GRCm39)	missense	probably damaging	1.00
Z1177:Trav14-1	UTSW	14	53,791,836 (GRCm39)	missense	probably benign	0.03

Posted On

2015-04-16