Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02238:Zfp735'

285985

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp735

Ensembl Gene

ENSMUSG00000060630

Gene Name

zinc finger protein 735

Synonyms

1700012C15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

IGL02238

Quality Score

Status

Chromosome

Chromosomal Location

73579604-73604624 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 73601319 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Glutamic Acid at position 88 (K88E)

Ref Sequence

ENSEMBL: ENSMUSP00000079269 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080407]

AlphaFold

B1ARH2

Predicted Effect

probably benign
Transcript: ENSMUST00000080407
AA Change: K88E

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000079269
Gene: ENSMUSG00000060630
AA Change: K88E

Domain	Start	End	E-Value	Type
KRAB	8	68	2.2e-34	SMART
ZnF_C2H2	483	505	4.38e1	SMART
ZnF_C2H2	511	533	2.67e-1	SMART
ZnF_C2H2	539	561	1.81e1	SMART
ZnF_C2H2	567	589	1.5e-4	SMART
ZnF_C2H2	595	617	4.87e-4	SMART
ZnF_C2H2	623	645	4.24e-4	SMART
ZnF_C2H2	651	673	2.27e-4	SMART
ZnF_C2H2	679	701	7.49e-5	SMART
ZnF_C2H2	707	729	4.87e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145996

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149560

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca15	T	A	7: 119,995,829 (GRCm39)	I1322N	probably benign	Het
Adamts1	A	T	16: 85,592,713 (GRCm39)	M565K	probably benign	Het
Akr1b7	T	A	6: 34,392,333 (GRCm39)	Y49N	probably damaging	Het
Cacna2d2	T	A	9: 107,390,757 (GRCm39)	V363E	probably damaging	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cdh10	C	T	15: 19,013,605 (GRCm39)	T735I	probably damaging	Het
Cds1	T	A	5: 101,962,302 (GRCm39)	C306S	possibly damaging	Het
Cfap251	T	C	5: 123,440,486 (GRCm39)	Y1091H	probably damaging	Het
Clasp2	T	C	9: 113,709,088 (GRCm39)	C644R	probably damaging	Het
Coil	T	C	11: 88,872,580 (GRCm39)	S314P	probably benign	Het
D630045J12Rik	T	A	6: 38,173,329 (GRCm39)	M280L	probably benign	Het
Dmxl2	C	T	9: 54,352,717 (GRCm39)	V795M	probably damaging	Het
Dock10	A	G	1: 80,511,510 (GRCm39)	V1533A	probably damaging	Het
Fbxo40	T	C	16: 36,789,536 (GRCm39)	N525D	possibly damaging	Het
Fezf2	T	C	14: 12,344,494 (GRCm38)	E231G	probably damaging	Het
Fmn1	T	C	2: 113,412,470 (GRCm39)	V870A	possibly damaging	Het
Ifi44	A	G	3: 151,438,019 (GRCm39)	*423Q	probably null	Het
Invs	T	C	4: 48,390,029 (GRCm39)	V173A	probably damaging	Het
Krt88	A	G	15: 101,350,486 (GRCm39)		probably benign	Het
Mctp2	A	T	7: 71,739,953 (GRCm39)	Y812*	probably null	Het
Neto2	T	C	8: 86,396,292 (GRCm39)	I118V	probably damaging	Het
Nutm2	T	G	13: 50,625,075 (GRCm39)	M264R	probably damaging	Het
Or2d2	A	G	7: 106,728,244 (GRCm39)	S119P	probably damaging	Het
Or8u8	T	C	2: 86,011,939 (GRCm39)		probably null	Het
Pcnx1	G	A	12: 81,964,688 (GRCm39)	R285Q	probably damaging	Het
Pi16	G	T	17: 29,545,269 (GRCm39)	K177N	probably damaging	Het
Pigg	C	T	5: 108,466,794 (GRCm39)	S225F	possibly damaging	Het
Prrc2b	T	A	2: 32,103,429 (GRCm39)	V969E	probably damaging	Het
Rab4b	A	C	7: 26,872,154 (GRCm39)	Y189D	probably benign	Het
Ran	A	G	5: 129,099,246 (GRCm39)	N143D	possibly damaging	Het
Rfc4	A	T	16: 22,933,219 (GRCm39)	F286L	probably damaging	Het
Sel1l2	T	C	2: 140,089,859 (GRCm39)	Y418C	probably damaging	Het
Slc13a1	T	C	6: 24,103,482 (GRCm39)	I354V	probably benign	Het
Slc7a2	A	T	8: 41,361,193 (GRCm39)	T386S	probably benign	Het
Tm2d2	G	T	8: 25,512,787 (GRCm39)	V212F	probably benign	Het
Tmem247	A	T	17: 87,225,721 (GRCm39)	N54Y	probably damaging	Het
Txnrd3	T	A	6: 89,633,117 (GRCm39)	Y206N	probably benign	Het
Uba5	T	C	9: 103,931,259 (GRCm39)		probably benign	Het
Vmn2r54	A	G	7: 12,369,910 (GRCm39)	L51P	probably damaging	Het

Other mutations in Zfp735

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00492:Zfp735	APN	11	73,602,192 (GRCm39)	missense	possibly damaging	0.86
IGL00798:Zfp735	APN	11	73,602,386 (GRCm39)	missense	possibly damaging	0.72
IGL01642:Zfp735	APN	11	73,601,305 (GRCm39)	missense	possibly damaging	0.73
IGL01684:Zfp735	APN	11	73,581,191 (GRCm39)	missense	possibly damaging	0.86
IGL02096:Zfp735	APN	11	73,602,254 (GRCm39)	missense	probably benign	0.01
IGL02505:Zfp735	APN	11	73,580,626 (GRCm39)	missense	probably benign	0.03
IGL02740:Zfp735	APN	11	73,601,412 (GRCm39)	missense	possibly damaging	0.53
IGL02957:Zfp735	APN	11	73,601,755 (GRCm39)	missense	probably benign	0.00
bananaquit	UTSW	11	73,601,412 (GRCm39)	nonsense	probably null
bescher	UTSW	11	73,602,979 (GRCm39)	missense	possibly damaging	0.93
Galvanic	UTSW	11	73,602,504 (GRCm39)	nonsense	probably null
grassquit	UTSW	11	73,603,029 (GRCm39)	missense	possibly damaging	0.66
R0114:Zfp735	UTSW	11	73,601,488 (GRCm39)	missense	probably benign	0.33
R0217:Zfp735	UTSW	11	73,602,112 (GRCm39)	missense	possibly damaging	0.73
R0943:Zfp735	UTSW	11	73,602,909 (GRCm39)	missense	probably benign	0.04
R1421:Zfp735	UTSW	11	73,601,523 (GRCm39)	missense	probably benign
R1460:Zfp735	UTSW	11	73,603,159 (GRCm39)	missense	possibly damaging	0.73
R1493:Zfp735	UTSW	11	73,601,305 (GRCm39)	missense	possibly damaging	0.73
R1517:Zfp735	UTSW	11	73,601,470 (GRCm39)	missense	probably benign
R1676:Zfp735	UTSW	11	73,602,301 (GRCm39)	missense	possibly damaging	0.53
R1709:Zfp735	UTSW	11	73,602,589 (GRCm39)	missense	probably benign	0.01
R1871:Zfp735	UTSW	11	73,601,412 (GRCm39)	nonsense	probably null
R1931:Zfp735	UTSW	11	73,602,677 (GRCm39)	missense	possibly damaging	0.69
R2219:Zfp735	UTSW	11	73,601,851 (GRCm39)	missense	possibly damaging	0.53
R2227:Zfp735	UTSW	11	73,602,223 (GRCm39)	nonsense	probably null
R2227:Zfp735	UTSW	11	73,602,222 (GRCm39)	missense	possibly damaging	0.53
R3552:Zfp735	UTSW	11	73,602,067 (GRCm39)	nonsense	probably null
R3856:Zfp735	UTSW	11	73,602,282 (GRCm39)	missense	probably benign	0.01
R3925:Zfp735	UTSW	11	73,601,950 (GRCm39)	missense	probably benign	0.33
R4572:Zfp735	UTSW	11	73,580,611 (GRCm39)	missense	probably benign	0.02
R4585:Zfp735	UTSW	11	73,580,550 (GRCm39)	missense	possibly damaging	0.51
R4586:Zfp735	UTSW	11	73,580,550 (GRCm39)	missense	possibly damaging	0.51
R4619:Zfp735	UTSW	11	73,602,031 (GRCm39)	missense	probably damaging	0.98
R4687:Zfp735	UTSW	11	73,602,682 (GRCm39)	missense	probably damaging	0.98
R4687:Zfp735	UTSW	11	73,602,681 (GRCm39)	missense	probably damaging	0.98
R5435:Zfp735	UTSW	11	73,602,939 (GRCm39)	missense	possibly damaging	0.72
R5489:Zfp735	UTSW	11	73,601,419 (GRCm39)	nonsense	probably null
R5516:Zfp735	UTSW	11	73,601,640 (GRCm39)	missense	probably benign
R5654:Zfp735	UTSW	11	73,602,964 (GRCm39)	missense	possibly damaging	0.71
R5990:Zfp735	UTSW	11	73,581,174 (GRCm39)	missense	possibly damaging	0.70
R6332:Zfp735	UTSW	11	73,602,504 (GRCm39)	nonsense	probably null
R6427:Zfp735	UTSW	11	73,581,140 (GRCm39)	missense	possibly damaging	0.73
R6460:Zfp735	UTSW	11	73,602,478 (GRCm39)	missense	probably benign	0.33
R6820:Zfp735	UTSW	11	73,579,783 (GRCm39)	start codon destroyed	probably null	0.01
R6831:Zfp735	UTSW	11	73,601,434 (GRCm39)	missense	probably damaging	1.00
R6833:Zfp735	UTSW	11	73,601,434 (GRCm39)	missense	probably damaging	1.00
R6834:Zfp735	UTSW	11	73,601,434 (GRCm39)	missense	probably damaging	1.00
R6897:Zfp735	UTSW	11	73,601,880 (GRCm39)	missense	probably benign	0.08
R6941:Zfp735	UTSW	11	73,581,159 (GRCm39)	missense	probably benign	0.33
R7335:Zfp735	UTSW	11	73,602,379 (GRCm39)	missense	possibly damaging	0.47
R7366:Zfp735	UTSW	11	73,602,979 (GRCm39)	missense	possibly damaging	0.93
R7474:Zfp735	UTSW	11	73,602,002 (GRCm39)	missense	possibly damaging	0.72
R7487:Zfp735	UTSW	11	73,581,154 (GRCm39)	missense	possibly damaging	0.53
R7583:Zfp735	UTSW	11	73,601,933 (GRCm39)	missense	possibly damaging	0.86
R7866:Zfp735	UTSW	11	73,601,629 (GRCm39)	missense	probably benign	0.00
R8005:Zfp735	UTSW	11	73,603,140 (GRCm39)	nonsense	probably null
R8500:Zfp735	UTSW	11	73,601,811 (GRCm39)	missense	possibly damaging	0.53
R8551:Zfp735	UTSW	11	73,603,122 (GRCm39)	missense	probably benign	0.06
R8754:Zfp735	UTSW	11	73,603,000 (GRCm39)	missense	possibly damaging	0.85
R8769:Zfp735	UTSW	11	73,581,127 (GRCm39)	missense	possibly damaging	0.53
R8794:Zfp735	UTSW	11	73,603,029 (GRCm39)	missense	possibly damaging	0.66
R8835:Zfp735	UTSW	11	73,601,692 (GRCm39)	missense	possibly damaging	0.53
R8869:Zfp735	UTSW	11	73,602,510 (GRCm39)	missense	possibly damaging	0.53
R8969:Zfp735	UTSW	11	73,602,699 (GRCm39)	missense	possibly damaging	0.83
R9072:Zfp735	UTSW	11	73,603,060 (GRCm39)	missense	probably benign	0.21
R9073:Zfp735	UTSW	11	73,603,060 (GRCm39)	missense	probably benign	0.21
R9193:Zfp735	UTSW	11	73,580,600 (GRCm39)	missense	possibly damaging	0.71
R9355:Zfp735	UTSW	11	73,602,362 (GRCm39)	missense	probably benign	0.01
R9414:Zfp735	UTSW	11	73,602,023 (GRCm39)	nonsense	probably null
R9456:Zfp735	UTSW	11	73,602,403 (GRCm39)	missense	possibly damaging	0.53
R9573:Zfp735	UTSW	11	73,602,936 (GRCm39)	missense	possibly damaging	0.67
R9647:Zfp735	UTSW	11	73,580,600 (GRCm39)	missense	probably damaging	0.98
R9710:Zfp735	UTSW	11	73,601,806 (GRCm39)	missense	possibly damaging	0.86
Z1176:Zfp735	UTSW	11	73,601,641 (GRCm39)	missense	probably benign	0.02

Posted On

2015-04-16