Incidental Mutation 'IGL02239:Qrsl1'
ID286002
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Qrsl1
Ensembl Gene ENSMUSG00000019863
Gene Nameglutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
SynonymsGatA, 2700038P16Rik
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.963) question?
Stock #IGL02239
Quality Score
Status
Chromosome10
Chromosomal Location43874188-43901745 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 43894600 bp
ZygosityHeterozygous
Amino Acid Change Proline to Serine at position 99 (P99S)
Ref Sequence ENSEMBL: ENSMUSP00000020012 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020012]
Predicted Effect possibly damaging
Transcript: ENSMUST00000020012
AA Change: P99S

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000020012
Gene: ENSMUSG00000019863
AA Change: P99S

DomainStartEndE-ValueType
Pfam:Amidase 22 484 6e-129 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154405
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216786
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217541
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5830411N06Rik T C 7: 140,295,843 F340S probably damaging Het
Abcf3 A G 16: 20,550,636 E262G possibly damaging Het
Adgra3 T A 5: 49,960,712 S1165C probably damaging Het
Akap11 A G 14: 78,513,849 L366P probably damaging Het
Astn1 T C 1: 158,664,130 probably null Het
Bhmt2 C T 13: 93,663,179 G250R probably benign Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cntnap2 A G 6: 47,021,654 D880G probably damaging Het
Erc1 A G 6: 119,773,891 V443A probably damaging Het
Fbxw15 A G 9: 109,559,837 I168T probably benign Het
Fgfr2 C T 7: 130,177,686 A504T probably damaging Het
Galm A G 17: 80,145,038 D135G probably damaging Het
Gstp3 C T 19: 4,057,899 V145I possibly damaging Het
Hspa5 T C 2: 34,772,776 F115L probably benign Het
Lig4 A C 8: 9,972,473 S436A probably damaging Het
Ncam1 A G 9: 49,567,402 V99A probably damaging Het
Nell1 T A 7: 50,249,650 I336N probably benign Het
Olfr44 T A 9: 39,484,561 I231F probably damaging Het
Olfr476 T C 7: 107,968,047 S217P probably damaging Het
Olfr600 T C 7: 103,346,598 Y110C probably damaging Het
Patl1 A T 19: 11,937,359 K625* probably null Het
Rfx8 T C 1: 39,680,886 D343G probably benign Het
Serpinb3a T A 1: 107,051,688 Y28F probably benign Het
Slc6a4 A T 11: 77,027,156 I575F probably benign Het
Tbx5 T A 5: 119,871,280 S285T possibly damaging Het
Tmem229a A T 6: 24,955,540 S72T probably damaging Het
Ttn T C 2: 76,746,404 D24715G probably damaging Het
Zfp784 T C 7: 5,035,671 probably benign Het
Zswim2 T A 2: 83,938,763 K85* probably null Het
Other mutations in Qrsl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00477:Qrsl1 APN 10 43876492 missense probably damaging 1.00
IGL01724:Qrsl1 APN 10 43874608 missense probably benign 0.01
IGL01896:Qrsl1 APN 10 43876504 missense probably benign 0.02
IGL02192:Qrsl1 APN 10 43885014 missense probably damaging 1.00
IGL02478:Qrsl1 APN 10 43882162 missense probably damaging 0.97
IGL02756:Qrsl1 APN 10 43882114 missense probably benign 0.00
IGL03386:Qrsl1 APN 10 43876550 missense possibly damaging 0.63
R0277:Qrsl1 UTSW 10 43896007 critical splice donor site probably null
R0323:Qrsl1 UTSW 10 43896007 critical splice donor site probably null
R0674:Qrsl1 UTSW 10 43896001 splice site probably benign
R1054:Qrsl1 UTSW 10 43882081 missense probably damaging 1.00
R1719:Qrsl1 UTSW 10 43896030 missense probably damaging 0.97
R1743:Qrsl1 UTSW 10 43881515 missense probably damaging 1.00
R1854:Qrsl1 UTSW 10 43894545 missense probably damaging 1.00
R2233:Qrsl1 UTSW 10 43896096 missense probably benign 0.00
R4176:Qrsl1 UTSW 10 43884832 missense probably damaging 1.00
R4452:Qrsl1 UTSW 10 43882162 missense probably damaging 1.00
R4732:Qrsl1 UTSW 10 43876663 missense probably damaging 1.00
R4733:Qrsl1 UTSW 10 43876663 missense probably damaging 1.00
R5626:Qrsl1 UTSW 10 43881520 missense probably benign 0.00
R6159:Qrsl1 UTSW 10 43882193 missense probably benign 0.00
R7563:Qrsl1 UTSW 10 43876517 missense probably damaging 1.00
Posted On2015-04-16