Incidental Mutation 'IGL02239:Qrsl1'
ID 286002
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Qrsl1
Ensembl Gene ENSMUSG00000019863
Gene Name glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Synonyms 2700038P16Rik, GatA
Accession Numbers
Essential gene? Probably essential (E-score: 0.958) question?
Stock # IGL02239
Quality Score
Status
Chromosome 10
Chromosomal Location 43750184-43777741 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 43770596 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 99 (P99S)
Ref Sequence ENSEMBL: ENSMUSP00000020012 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020012]
AlphaFold Q9CZN8
Predicted Effect possibly damaging
Transcript: ENSMUST00000020012
AA Change: P99S

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000020012
Gene: ENSMUSG00000019863
AA Change: P99S

DomainStartEndE-ValueType
Pfam:Amidase 22 484 6e-129 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154405
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216786
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217541
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf3 A G 16: 20,369,386 (GRCm39) E262G possibly damaging Het
Adgra3 T A 5: 50,118,054 (GRCm39) S1165C probably damaging Het
Akap11 A G 14: 78,751,289 (GRCm39) L366P probably damaging Het
Astn1 T C 1: 158,491,700 (GRCm39) probably null Het
Bhmt2 C T 13: 93,799,687 (GRCm39) G250R probably benign Het
Cdc45 C T 16: 18,617,479 (GRCm39) M200I probably benign Het
Cntnap2 A G 6: 46,998,588 (GRCm39) D880G probably damaging Het
Erc1 A G 6: 119,750,852 (GRCm39) V443A probably damaging Het
Fbxw15 A G 9: 109,388,905 (GRCm39) I168T probably benign Het
Fgfr2 C T 7: 129,779,416 (GRCm39) A504T probably damaging Het
Galm A G 17: 80,452,467 (GRCm39) D135G probably damaging Het
Gstp3 C T 19: 4,107,899 (GRCm39) V145I possibly damaging Het
Hspa5 T C 2: 34,662,788 (GRCm39) F115L probably benign Het
Lig4 A C 8: 10,022,473 (GRCm39) S436A probably damaging Het
Ncam1 A G 9: 49,478,702 (GRCm39) V99A probably damaging Het
Nell1 T A 7: 49,899,398 (GRCm39) I336N probably benign Het
Or52ad1 T C 7: 102,995,805 (GRCm39) Y110C probably damaging Het
Or5p55 T C 7: 107,567,254 (GRCm39) S217P probably damaging Het
Or8g20 T A 9: 39,395,857 (GRCm39) I231F probably damaging Het
Patl1 A T 19: 11,914,723 (GRCm39) K625* probably null Het
Rfx8 T C 1: 39,720,046 (GRCm39) D343G probably benign Het
Scart2 T C 7: 139,875,756 (GRCm39) F340S probably damaging Het
Serpinb3a T A 1: 106,979,418 (GRCm39) Y28F probably benign Het
Slc6a4 A T 11: 76,917,982 (GRCm39) I575F probably benign Het
Tbx5 T A 5: 120,009,345 (GRCm39) S285T possibly damaging Het
Tmem229a A T 6: 24,955,539 (GRCm39) S72T probably damaging Het
Ttn T C 2: 76,576,748 (GRCm39) D24715G probably damaging Het
Zfp784 T C 7: 5,038,670 (GRCm39) probably benign Het
Zswim2 T A 2: 83,769,107 (GRCm39) K85* probably null Het
Other mutations in Qrsl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00477:Qrsl1 APN 10 43,752,488 (GRCm39) missense probably damaging 1.00
IGL01724:Qrsl1 APN 10 43,750,604 (GRCm39) missense probably benign 0.01
IGL01896:Qrsl1 APN 10 43,752,500 (GRCm39) missense probably benign 0.02
IGL02192:Qrsl1 APN 10 43,761,010 (GRCm39) missense probably damaging 1.00
IGL02478:Qrsl1 APN 10 43,758,158 (GRCm39) missense probably damaging 0.97
IGL02756:Qrsl1 APN 10 43,758,110 (GRCm39) missense probably benign 0.00
IGL03386:Qrsl1 APN 10 43,752,546 (GRCm39) missense possibly damaging 0.63
R0277:Qrsl1 UTSW 10 43,772,003 (GRCm39) critical splice donor site probably null
R0323:Qrsl1 UTSW 10 43,772,003 (GRCm39) critical splice donor site probably null
R0674:Qrsl1 UTSW 10 43,771,997 (GRCm39) splice site probably benign
R1054:Qrsl1 UTSW 10 43,758,077 (GRCm39) missense probably damaging 1.00
R1719:Qrsl1 UTSW 10 43,772,026 (GRCm39) missense probably damaging 0.97
R1743:Qrsl1 UTSW 10 43,757,511 (GRCm39) missense probably damaging 1.00
R1854:Qrsl1 UTSW 10 43,770,541 (GRCm39) missense probably damaging 1.00
R2233:Qrsl1 UTSW 10 43,772,092 (GRCm39) missense probably benign 0.00
R4176:Qrsl1 UTSW 10 43,760,828 (GRCm39) missense probably damaging 1.00
R4452:Qrsl1 UTSW 10 43,758,158 (GRCm39) missense probably damaging 1.00
R4732:Qrsl1 UTSW 10 43,752,659 (GRCm39) missense probably damaging 1.00
R4733:Qrsl1 UTSW 10 43,752,659 (GRCm39) missense probably damaging 1.00
R5626:Qrsl1 UTSW 10 43,757,516 (GRCm39) missense probably benign 0.00
R6159:Qrsl1 UTSW 10 43,758,189 (GRCm39) missense probably benign 0.00
R7563:Qrsl1 UTSW 10 43,752,513 (GRCm39) missense probably damaging 1.00
R8050:Qrsl1 UTSW 10 43,750,631 (GRCm39) missense probably damaging 0.98
R8092:Qrsl1 UTSW 10 43,760,749 (GRCm39) missense probably damaging 1.00
R8221:Qrsl1 UTSW 10 43,758,080 (GRCm39) missense possibly damaging 0.81
R8331:Qrsl1 UTSW 10 43,752,521 (GRCm39) missense probably damaging 0.98
Z1176:Qrsl1 UTSW 10 43,760,944 (GRCm39) missense probably damaging 0.98
Posted On 2015-04-16