Incidental Mutation 'IGL02243:Iqcg'
ID 286059
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Iqcg
Ensembl Gene ENSMUSG00000035578
Gene Name IQ motif containing G
Synonyms 2400003L07Rik, esgd12d, repro1, stubby12d, G1-374-12
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02243
Quality Score
Status
Chromosome 16
Chromosomal Location 32834640-32876617 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 32865962 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 127 (D127G)
Ref Sequence ENSEMBL: ENSMUSP00000110752 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040309] [ENSMUST00000115100]
AlphaFold Q80W32
Predicted Effect noncoding transcript
Transcript: ENSMUST00000040309
SMART Domains Protein: ENSMUSP00000041686
Gene: ENSMUSG00000035578

DomainStartEndE-ValueType
low complexity region 38 53 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000105610
Predicted Effect probably damaging
Transcript: ENSMUST00000115100
AA Change: D127G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000110752
Gene: ENSMUSG00000035578
AA Change: D127G

DomainStartEndE-ValueType
low complexity region 3 50 N/A INTRINSIC
low complexity region 101 116 N/A INTRINSIC
coiled coil region 248 329 N/A INTRINSIC
IQ 371 393 1.54e-2 SMART
low complexity region 399 419 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126793
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231235
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous male mice are infertile and have very low epididymal sperm concentration with low motility, predominantly appearing as sperm heads without tails or with short tails. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apc2 A G 10: 80,138,175 (GRCm39) Y87C probably damaging Het
Armc3 G A 2: 19,290,948 (GRCm39) probably null Het
Brsk2 T C 7: 141,547,036 (GRCm39) F493S probably damaging Het
Cd19 T C 7: 126,009,965 (GRCm39) probably null Het
Cfap91 T C 16: 38,162,142 (GRCm39) probably benign Het
Chd2 T C 7: 73,147,456 (GRCm39) probably null Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Ddx19a T G 8: 111,703,088 (GRCm39) I450L probably benign Het
Edn2 G A 4: 120,019,229 (GRCm39) probably null Het
Elp2 G A 18: 24,755,663 (GRCm39) R470Q probably benign Het
Fhdc1 T G 3: 84,381,947 (GRCm39) M1L possibly damaging Het
Gba2 A T 4: 43,568,719 (GRCm39) I619N probably benign Het
Glce A G 9: 61,977,422 (GRCm39) F154S probably damaging Het
Gm3476 A T 14: 6,122,811 (GRCm38) C195* probably null Het
Hsp90aa1 A G 12: 110,661,525 (GRCm39) S164P probably damaging Het
Jag2 G A 12: 112,879,965 (GRCm39) T381I possibly damaging Het
Krt16 A T 11: 100,137,162 (GRCm39) probably benign Het
Lhx2 T A 2: 38,243,531 (GRCm39) probably benign Het
Lrrc2 A T 9: 110,799,125 (GRCm39) N158I probably damaging Het
M1ap C T 6: 83,003,269 (GRCm39) P389S probably damaging Het
Masp2 A T 4: 148,687,525 (GRCm39) D104V probably benign Het
Met G A 6: 17,549,093 (GRCm39) V982I probably damaging Het
Msh2 T A 17: 87,985,796 (GRCm39) probably benign Het
Myh9 A G 15: 77,651,682 (GRCm39) L1509P probably damaging Het
Mylk2 A G 2: 152,762,473 (GRCm39) H554R probably damaging Het
Oxr1 T G 15: 41,399,097 (GRCm39) probably benign Het
Pdp1 A T 4: 11,961,873 (GRCm39) V146D probably benign Het
Pdzrn4 A T 15: 92,668,577 (GRCm39) M910L probably benign Het
Prl2a1 T C 13: 27,991,400 (GRCm39) probably benign Het
Rapgef6 C T 11: 54,567,226 (GRCm39) P1136S probably damaging Het
Rasgef1c A T 11: 49,848,217 (GRCm39) S69C possibly damaging Het
Rnaseh1 C T 12: 28,705,631 (GRCm39) R152W probably damaging Het
Sele T C 1: 163,880,537 (GRCm39) V373A probably benign Het
Tmem67 G A 4: 12,070,584 (GRCm39) S314L possibly damaging Het
Traf4 T C 11: 78,051,343 (GRCm39) E271G probably benign Het
Trim39 T C 17: 36,571,276 (GRCm39) D494G probably damaging Het
Virma G A 4: 11,546,031 (GRCm39) R1673Q probably damaging Het
Other mutations in Iqcg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01106:Iqcg APN 16 32,855,970 (GRCm39) missense possibly damaging 0.90
IGL01155:Iqcg APN 16 32,861,245 (GRCm39) missense probably damaging 0.99
IGL01602:Iqcg APN 16 32,837,348 (GRCm39) unclassified probably benign
IGL01605:Iqcg APN 16 32,837,348 (GRCm39) unclassified probably benign
IGL02328:Iqcg APN 16 32,839,876 (GRCm39) missense probably benign 0.00
IGL02490:Iqcg APN 16 32,855,937 (GRCm39) nonsense probably null
IGL03297:Iqcg APN 16 32,856,002 (GRCm39) splice site probably benign
R0038:Iqcg UTSW 16 32,866,012 (GRCm39) missense probably benign 0.03
R0453:Iqcg UTSW 16 32,870,213 (GRCm39) splice site probably benign
R0719:Iqcg UTSW 16 32,861,215 (GRCm39) missense probably benign 0.26
R1191:Iqcg UTSW 16 32,870,313 (GRCm39) missense probably benign 0.43
R1544:Iqcg UTSW 16 32,865,895 (GRCm39) missense probably benign 0.01
R2292:Iqcg UTSW 16 32,870,253 (GRCm39) missense probably benign 0.25
R3725:Iqcg UTSW 16 32,840,909 (GRCm39) splice site probably null
R3726:Iqcg UTSW 16 32,849,411 (GRCm39) missense probably damaging 1.00
R3732:Iqcg UTSW 16 32,873,996 (GRCm39) unclassified probably benign
R3732:Iqcg UTSW 16 32,873,996 (GRCm39) unclassified probably benign
R3733:Iqcg UTSW 16 32,873,996 (GRCm39) unclassified probably benign
R3734:Iqcg UTSW 16 32,873,996 (GRCm39) unclassified probably benign
R3770:Iqcg UTSW 16 32,870,378 (GRCm39) synonymous silent
R4296:Iqcg UTSW 16 32,837,345 (GRCm39) unclassified probably benign
R4409:Iqcg UTSW 16 32,865,888 (GRCm39) critical splice donor site probably null
R4410:Iqcg UTSW 16 32,851,186 (GRCm39) missense possibly damaging 0.95
R4429:Iqcg UTSW 16 32,839,860 (GRCm39) missense probably benign 0.02
R4603:Iqcg UTSW 16 32,861,133 (GRCm39) critical splice donor site probably null
R4603:Iqcg UTSW 16 32,861,134 (GRCm39) missense probably null 0.68
R4979:Iqcg UTSW 16 32,839,884 (GRCm39) missense probably damaging 1.00
R5672:Iqcg UTSW 16 32,839,878 (GRCm39) missense probably damaging 0.99
R6183:Iqcg UTSW 16 32,851,293 (GRCm39) missense probably damaging 1.00
R6965:Iqcg UTSW 16 32,851,174 (GRCm39) missense probably benign 0.06
R8135:Iqcg UTSW 16 32,849,394 (GRCm39) missense probably benign 0.20
R9260:Iqcg UTSW 16 32,855,973 (GRCm39) nonsense probably null
R9505:Iqcg UTSW 16 32,861,247 (GRCm39) missense probably benign 0.42
Z1177:Iqcg UTSW 16 32,849,390 (GRCm39) nonsense probably null
Posted On 2015-04-16