Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02243:Prl2a1'

286079

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prl2a1

Ensembl Gene

ENSMUSG00000022886

Gene Name

prolactin family 2, subfamily a, member 1

Synonyms

PLP-M, Prlpm

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL02243

Quality Score

Status

Chromosome

Chromosomal Location

27985638-27992699 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 27991400 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000023602 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023602]

AlphaFold

Q9JHK0

Predicted Effect

probably benign
Transcript: ENSMUST00000023602

SMART Domains

Protein: ENSMUSP00000023602
Gene: ENSMUSG00000022886

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	16	228	6.1e-67	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Apc2	A	G	10: 80,138,175 (GRCm39)	Y87C	probably damaging	Het
Armc3	G	A	2: 19,290,948 (GRCm39)		probably null	Het
Brsk2	T	C	7: 141,547,036 (GRCm39)	F493S	probably damaging	Het
Cd19	T	C	7: 126,009,965 (GRCm39)		probably null	Het
Cfap91	T	C	16: 38,162,142 (GRCm39)		probably benign	Het
Chd2	T	C	7: 73,147,456 (GRCm39)		probably null	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Ddx19a	T	G	8: 111,703,088 (GRCm39)	I450L	probably benign	Het
Edn2	G	A	4: 120,019,229 (GRCm39)		probably null	Het
Elp2	G	A	18: 24,755,663 (GRCm39)	R470Q	probably benign	Het
Fhdc1	T	G	3: 84,381,947 (GRCm39)	M1L	possibly damaging	Het
Gba2	A	T	4: 43,568,719 (GRCm39)	I619N	probably benign	Het
Glce	A	G	9: 61,977,422 (GRCm39)	F154S	probably damaging	Het
Gm3476	A	T	14: 6,122,811 (GRCm38)	C195*	probably null	Het
Hsp90aa1	A	G	12: 110,661,525 (GRCm39)	S164P	probably damaging	Het
Iqcg	T	C	16: 32,865,962 (GRCm39)	D127G	probably damaging	Het
Jag2	G	A	12: 112,879,965 (GRCm39)	T381I	possibly damaging	Het
Krt16	A	T	11: 100,137,162 (GRCm39)		probably benign	Het
Lhx2	T	A	2: 38,243,531 (GRCm39)		probably benign	Het
Lrrc2	A	T	9: 110,799,125 (GRCm39)	N158I	probably damaging	Het
M1ap	C	T	6: 83,003,269 (GRCm39)	P389S	probably damaging	Het
Masp2	A	T	4: 148,687,525 (GRCm39)	D104V	probably benign	Het
Met	G	A	6: 17,549,093 (GRCm39)	V982I	probably damaging	Het
Msh2	T	A	17: 87,985,796 (GRCm39)		probably benign	Het
Myh9	A	G	15: 77,651,682 (GRCm39)	L1509P	probably damaging	Het
Mylk2	A	G	2: 152,762,473 (GRCm39)	H554R	probably damaging	Het
Oxr1	T	G	15: 41,399,097 (GRCm39)		probably benign	Het
Pdp1	A	T	4: 11,961,873 (GRCm39)	V146D	probably benign	Het
Pdzrn4	A	T	15: 92,668,577 (GRCm39)	M910L	probably benign	Het
Rapgef6	C	T	11: 54,567,226 (GRCm39)	P1136S	probably damaging	Het
Rasgef1c	A	T	11: 49,848,217 (GRCm39)	S69C	possibly damaging	Het
Rnaseh1	C	T	12: 28,705,631 (GRCm39)	R152W	probably damaging	Het
Sele	T	C	1: 163,880,537 (GRCm39)	V373A	probably benign	Het
Tmem67	G	A	4: 12,070,584 (GRCm39)	S314L	possibly damaging	Het
Traf4	T	C	11: 78,051,343 (GRCm39)	E271G	probably benign	Het
Trim39	T	C	17: 36,571,276 (GRCm39)	D494G	probably damaging	Het
Virma	G	A	4: 11,546,031 (GRCm39)	R1673Q	probably damaging	Het

Other mutations in Prl2a1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00673:Prl2a1	APN	13	27,992,436 (GRCm39)	missense	probably damaging	1.00
IGL01977:Prl2a1	APN	13	27,990,261 (GRCm39)	missense	probably damaging	0.96
IGL02666:Prl2a1	APN	13	27,990,310 (GRCm39)	missense	possibly damaging	0.84
IGL02950:Prl2a1	APN	13	27,988,914 (GRCm39)	missense	probably damaging	1.00
IGL03390:Prl2a1	APN	13	27,985,699 (GRCm39)	missense	probably benign	0.00
R1795:Prl2a1	UTSW	13	27,992,554 (GRCm39)	missense	probably damaging	1.00
R1867:Prl2a1	UTSW	13	27,988,923 (GRCm39)	missense	probably damaging	1.00
R1868:Prl2a1	UTSW	13	27,988,923 (GRCm39)	missense	probably damaging	1.00
R2221:Prl2a1	UTSW	13	27,990,369 (GRCm39)	critical splice donor site	probably null
R3969:Prl2a1	UTSW	13	27,990,263 (GRCm39)	missense	probably benign	0.00
R4772:Prl2a1	UTSW	13	27,988,961 (GRCm39)	missense	probably benign	0.02
R5604:Prl2a1	UTSW	13	27,990,369 (GRCm39)	critical splice donor site	probably benign
R7292:Prl2a1	UTSW	13	27,991,353 (GRCm39)	splice site	probably null
R9110:Prl2a1	UTSW	13	27,992,398 (GRCm39)	missense	probably benign	0.03
R9193:Prl2a1	UTSW	13	27,992,535 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16