Incidental Mutation 'IGL02243:Armc3'
ID 286080
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Armc3
Ensembl Gene ENSMUSG00000037683
Gene Name armadillo repeat containing 3
Synonyms 4921513G22Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # IGL02243
Quality Score
Status
Chromosome 2
Chromosomal Location 19204113-19315052 bp(+) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) G to A at 19290948 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000110287 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049255] [ENSMUST00000114640]
AlphaFold A2AU72
Predicted Effect probably null
Transcript: ENSMUST00000049255
SMART Domains Protein: ENSMUSP00000048784
Gene: ENSMUSG00000037683

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
ARM 56 96 2.07e-2 SMART
ARM 97 138 9.84e1 SMART
ARM 139 179 7.86e-3 SMART
ARM 180 220 7.63e0 SMART
ARM 221 262 7.76e1 SMART
low complexity region 293 303 N/A INTRINSIC
ARM 305 345 3.91e1 SMART
ARM 346 385 2.93e-2 SMART
ARM 387 427 7.74e-2 SMART
Blast:ARM 428 468 3e-11 BLAST
ARM 469 509 1.45e-1 SMART
low complexity region 544 557 N/A INTRINSIC
low complexity region 583 595 N/A INTRINSIC
low complexity region 620 639 N/A INTRINSIC
low complexity region 675 696 N/A INTRINSIC
Pfam:EDR1 723 857 3.1e-28 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000114640
SMART Domains Protein: ENSMUSP00000110287
Gene: ENSMUSG00000037683

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
ARM 56 96 2.07e-2 SMART
ARM 97 138 9.84e1 SMART
ARM 139 179 7.86e-3 SMART
ARM 180 220 7.63e0 SMART
ARM 221 262 7.76e1 SMART
low complexity region 293 303 N/A INTRINSIC
ARM 305 345 3.91e1 SMART
ARM 346 385 2.93e-2 SMART
ARM 387 427 7.74e-2 SMART
Blast:ARM 428 468 3e-11 BLAST
ARM 469 509 1.45e-1 SMART
Pfam:EDR1 549 868 1.4e-41 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Armadillo/beta-catenin (CTNNB1; MIM 116806)-like (ARM) domains are imperfect 45-amino acid repeats involved in protein-protein interactions. ARM domain-containing proteins, such as ARMC3, function in signal transduction, development, cell adhesion and mobility, and tumor initiation and metastasis (Li et al., 2006 [PubMed 16915934]).[supplied by OMIM, Mar 2008]
Allele List at MGI

All alleles(2) : Targeted(2)

Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apc2 A G 10: 80,138,175 (GRCm39) Y87C probably damaging Het
Brsk2 T C 7: 141,547,036 (GRCm39) F493S probably damaging Het
Cd19 T C 7: 126,009,965 (GRCm39) probably null Het
Cfap91 T C 16: 38,162,142 (GRCm39) probably benign Het
Chd2 T C 7: 73,147,456 (GRCm39) probably null Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Ddx19a T G 8: 111,703,088 (GRCm39) I450L probably benign Het
Edn2 G A 4: 120,019,229 (GRCm39) probably null Het
Elp2 G A 18: 24,755,663 (GRCm39) R470Q probably benign Het
Fhdc1 T G 3: 84,381,947 (GRCm39) M1L possibly damaging Het
Gba2 A T 4: 43,568,719 (GRCm39) I619N probably benign Het
Glce A G 9: 61,977,422 (GRCm39) F154S probably damaging Het
Gm3476 A T 14: 6,122,811 (GRCm38) C195* probably null Het
Hsp90aa1 A G 12: 110,661,525 (GRCm39) S164P probably damaging Het
Iqcg T C 16: 32,865,962 (GRCm39) D127G probably damaging Het
Jag2 G A 12: 112,879,965 (GRCm39) T381I possibly damaging Het
Krt16 A T 11: 100,137,162 (GRCm39) probably benign Het
Lhx2 T A 2: 38,243,531 (GRCm39) probably benign Het
Lrrc2 A T 9: 110,799,125 (GRCm39) N158I probably damaging Het
M1ap C T 6: 83,003,269 (GRCm39) P389S probably damaging Het
Masp2 A T 4: 148,687,525 (GRCm39) D104V probably benign Het
Met G A 6: 17,549,093 (GRCm39) V982I probably damaging Het
Msh2 T A 17: 87,985,796 (GRCm39) probably benign Het
Myh9 A G 15: 77,651,682 (GRCm39) L1509P probably damaging Het
Mylk2 A G 2: 152,762,473 (GRCm39) H554R probably damaging Het
Oxr1 T G 15: 41,399,097 (GRCm39) probably benign Het
Pdp1 A T 4: 11,961,873 (GRCm39) V146D probably benign Het
Pdzrn4 A T 15: 92,668,577 (GRCm39) M910L probably benign Het
Prl2a1 T C 13: 27,991,400 (GRCm39) probably benign Het
Rapgef6 C T 11: 54,567,226 (GRCm39) P1136S probably damaging Het
Rasgef1c A T 11: 49,848,217 (GRCm39) S69C possibly damaging Het
Rnaseh1 C T 12: 28,705,631 (GRCm39) R152W probably damaging Het
Sele T C 1: 163,880,537 (GRCm39) V373A probably benign Het
Tmem67 G A 4: 12,070,584 (GRCm39) S314L possibly damaging Het
Traf4 T C 11: 78,051,343 (GRCm39) E271G probably benign Het
Trim39 T C 17: 36,571,276 (GRCm39) D494G probably damaging Het
Virma G A 4: 11,546,031 (GRCm39) R1673Q probably damaging Het
Other mutations in Armc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00535:Armc3 APN 2 19,308,669 (GRCm39) missense possibly damaging 0.48
IGL01123:Armc3 APN 2 19,206,616 (GRCm39) missense possibly damaging 0.87
IGL01142:Armc3 APN 2 19,302,709 (GRCm39) splice site probably benign
IGL01556:Armc3 APN 2 19,273,957 (GRCm39) missense probably damaging 1.00
IGL02145:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02145:Armc3 APN 2 19,301,671 (GRCm39) missense possibly damaging 0.81
IGL02152:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02154:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02244:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02516:Armc3 APN 2 19,305,317 (GRCm39) missense possibly damaging 0.94
IGL02691:Armc3 APN 2 19,240,295 (GRCm39) missense probably damaging 1.00
IGL03151:Armc3 APN 2 19,243,509 (GRCm39) missense probably damaging 1.00
IGL03190:Armc3 APN 2 19,293,761 (GRCm39) missense probably damaging 0.99
IGL03288:Armc3 APN 2 19,240,293 (GRCm39) missense probably damaging 1.00
IGL03338:Armc3 APN 2 19,253,512 (GRCm39) missense possibly damaging 0.88
R0015:Armc3 UTSW 2 19,301,132 (GRCm39) critical splice acceptor site probably null
R0015:Armc3 UTSW 2 19,301,132 (GRCm39) critical splice acceptor site probably null
R0256:Armc3 UTSW 2 19,274,027 (GRCm39) missense probably damaging 1.00
R0621:Armc3 UTSW 2 19,300,204 (GRCm39) missense probably damaging 0.96
R1326:Armc3 UTSW 2 19,314,935 (GRCm39) makesense probably null
R1470:Armc3 UTSW 2 19,243,547 (GRCm39) missense probably benign
R1470:Armc3 UTSW 2 19,243,547 (GRCm39) missense probably benign
R1489:Armc3 UTSW 2 19,314,858 (GRCm39) missense probably benign 0.01
R1990:Armc3 UTSW 2 19,297,953 (GRCm39) missense probably damaging 0.97
R1991:Armc3 UTSW 2 19,297,953 (GRCm39) missense probably damaging 0.97
R1992:Armc3 UTSW 2 19,297,953 (GRCm39) missense probably damaging 0.97
R2002:Armc3 UTSW 2 19,293,747 (GRCm39) missense probably benign 0.01
R2095:Armc3 UTSW 2 19,293,740 (GRCm39) missense possibly damaging 0.65
R2127:Armc3 UTSW 2 19,206,622 (GRCm39) missense probably damaging 1.00
R2158:Armc3 UTSW 2 19,253,444 (GRCm39) missense probably damaging 0.99
R2697:Armc3 UTSW 2 19,308,746 (GRCm39) missense probably damaging 1.00
R3809:Armc3 UTSW 2 19,305,476 (GRCm39) missense probably damaging 1.00
R3897:Armc3 UTSW 2 19,273,988 (GRCm39) missense probably damaging 1.00
R4107:Armc3 UTSW 2 19,293,720 (GRCm39) missense probably benign 0.13
R4326:Armc3 UTSW 2 19,305,284 (GRCm39) missense probably damaging 0.97
R4464:Armc3 UTSW 2 19,253,470 (GRCm39) missense probably damaging 0.99
R4702:Armc3 UTSW 2 19,314,792 (GRCm39) missense probably damaging 1.00
R4923:Armc3 UTSW 2 19,297,791 (GRCm39) critical splice acceptor site probably null
R5370:Armc3 UTSW 2 19,290,873 (GRCm39) missense probably benign 0.00
R5518:Armc3 UTSW 2 19,302,739 (GRCm39) missense probably benign 0.28
R5718:Armc3 UTSW 2 19,308,610 (GRCm39) nonsense probably null
R5739:Armc3 UTSW 2 19,258,728 (GRCm39) missense possibly damaging 0.67
R5913:Armc3 UTSW 2 19,314,858 (GRCm39) missense possibly damaging 0.65
R6211:Armc3 UTSW 2 19,301,614 (GRCm39) critical splice acceptor site probably null
R6245:Armc3 UTSW 2 19,253,516 (GRCm39) missense probably damaging 1.00
R6841:Armc3 UTSW 2 19,206,630 (GRCm39) splice site probably null
R7003:Armc3 UTSW 2 19,274,839 (GRCm39) missense probably damaging 1.00
R7190:Armc3 UTSW 2 19,297,947 (GRCm39) missense probably damaging 1.00
R7499:Armc3 UTSW 2 19,290,790 (GRCm39) missense probably benign 0.03
R7738:Armc3 UTSW 2 19,293,761 (GRCm39) missense probably damaging 0.99
R7844:Armc3 UTSW 2 19,258,829 (GRCm39) missense possibly damaging 0.90
R7919:Armc3 UTSW 2 19,290,906 (GRCm39) missense probably benign 0.00
R8060:Armc3 UTSW 2 19,293,720 (GRCm39) missense probably benign 0.08
R8111:Armc3 UTSW 2 19,301,674 (GRCm39) missense probably benign
R8406:Armc3 UTSW 2 19,240,365 (GRCm39) missense probably damaging 0.98
R8485:Armc3 UTSW 2 19,297,945 (GRCm39) missense probably damaging 1.00
R8773:Armc3 UTSW 2 19,293,667 (GRCm39) missense probably benign 0.01
R8940:Armc3 UTSW 2 19,240,393 (GRCm39) missense probably damaging 1.00
R9441:Armc3 UTSW 2 19,253,426 (GRCm39) missense possibly damaging 0.89
Z1177:Armc3 UTSW 2 19,290,802 (GRCm39) missense probably benign
Posted On 2015-04-16