Incidental Mutation 'IGL02244:Armc8'
ID 286091
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Armc8
Ensembl Gene ENSMUSG00000032468
Gene Name armadillo repeat containing 8
Synonyms 1200015K23Rik, Gid5, HSPC056
Accession Numbers
Essential gene? Possibly essential (E-score: 0.683) question?
Stock # IGL02244
Quality Score
Status
Chromosome 9
Chromosomal Location 99360425-99450952 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 99365227 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 638 (D638E)
Ref Sequence ENSEMBL: ENSMUSP00000035043 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035043]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000035043
AA Change: D638E

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000035043
Gene: ENSMUSG00000032468
AA Change: D638E

DomainStartEndE-ValueType
ARM 50 92 1.75e0 SMART
ARM 94 134 5.34e0 SMART
ARM 177 217 2.04e1 SMART
ARM 372 413 3.58e1 SMART
Blast:ARM 414 455 7e-17 BLAST
ARM 457 497 3.81e-1 SMART
ARM 500 540 5.43e1 SMART
Blast:ARM 542 585 1e-20 BLAST
Blast:ARM 633 673 1e-16 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(6) : Targeted, other(2) Gene trapped(4)

Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438H23Rik G T 16: 90,853,085 (GRCm39) T17K probably benign Het
Agbl1 T C 7: 76,416,120 (GRCm39) S714P probably damaging Het
Araf A G X: 20,719,835 (GRCm39) probably benign Het
Armc3 G A 2: 19,290,948 (GRCm39) probably null Het
Bpifb5 C T 2: 154,067,068 (GRCm39) T107I possibly damaging Het
Ces1e A C 8: 93,938,977 (GRCm39) probably null Het
Col4a3 C A 1: 82,647,492 (GRCm39) probably benign Het
Col4a5 A G X: 140,382,669 (GRCm39) probably benign Het
Crocc T C 4: 140,765,231 (GRCm39) H477R probably benign Het
Dgkd C A 1: 87,842,863 (GRCm39) N130K probably benign Het
Dock1 C T 7: 134,379,174 (GRCm39) Q634* probably null Het
Dzip3 C T 16: 48,801,351 (GRCm39) V58I probably benign Het
Fndc3a A G 14: 72,793,807 (GRCm39) probably benign Het
Glp2r C T 11: 67,612,817 (GRCm39) R379H probably damaging Het
Kctd12b T A X: 152,472,330 (GRCm39) M120L probably benign Het
Krt33b A G 11: 99,916,189 (GRCm39) V258A probably benign Het
Lpin1 T A 12: 16,591,770 (GRCm39) N819I probably damaging Het
Lurap1l T C 4: 80,871,866 (GRCm39) S120P probably damaging Het
Lysmd4 T C 7: 66,875,672 (GRCm39) S112P probably damaging Het
Myo1e A G 9: 70,274,971 (GRCm39) K708R probably benign Het
Nr3c1 T A 18: 39,554,610 (GRCm39) probably benign Het
Nup62cl G T X: 138,922,780 (GRCm39) N239K probably benign Het
Nwd1 A T 8: 73,434,210 (GRCm39) E1269V probably damaging Het
Or52e7 C T 7: 104,685,152 (GRCm39) T249M probably damaging Het
Pcdh9 A C 14: 93,564,204 (GRCm39) L1084R probably damaging Het
Plxnd1 A G 6: 115,955,218 (GRCm39) M543T probably benign Het
Prss53 T A 7: 127,487,964 (GRCm39) T173S possibly damaging Het
Reep2 C A 18: 34,973,807 (GRCm39) probably benign Het
Rp1 T C 1: 4,419,003 (GRCm39) D703G probably benign Het
Sbf2 T G 7: 110,159,502 (GRCm39) D36A probably damaging Het
Sh3kbp1 C T X: 158,586,724 (GRCm39) R99W probably damaging Het
Sis T A 3: 72,863,523 (GRCm39) R238S probably benign Het
Slc35e2 T A 4: 155,703,019 (GRCm39) V344D probably damaging Het
Specc1 G A 11: 62,019,194 (GRCm39) V678I probably benign Het
Supt6 T C 11: 78,123,623 (GRCm39) D49G possibly damaging Het
Tecpr1 G A 5: 144,146,821 (GRCm39) A515V probably benign Het
Tlr4 G A 4: 66,752,298 (GRCm39) probably null Het
Tmco5b A G 2: 113,118,619 (GRCm39) E114G probably damaging Het
Tspear A T 10: 77,688,690 (GRCm39) probably benign Het
Txlnb T A 10: 17,719,116 (GRCm39) V649E probably benign Het
Utp20 A G 10: 88,651,818 (GRCm39) probably benign Het
Virma G A 4: 11,546,031 (GRCm39) R1673Q probably damaging Het
Vmn2r70 T A 7: 85,214,211 (GRCm39) T314S probably benign Het
Zfp938 G T 10: 82,061,906 (GRCm39) T238K possibly damaging Het
Other mutations in Armc8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00232:Armc8 APN 9 99,387,787 (GRCm39) critical splice acceptor site probably null
IGL00951:Armc8 APN 9 99,387,757 (GRCm39) missense probably benign 0.00
IGL01776:Armc8 APN 9 99,408,936 (GRCm39) splice site probably benign
IGL02215:Armc8 APN 9 99,366,031 (GRCm39) missense possibly damaging 0.92
IGL02610:Armc8 APN 9 99,409,122 (GRCm39) splice site probably benign
IGL02612:Armc8 APN 9 99,409,122 (GRCm39) splice site probably benign
IGL02615:Armc8 APN 9 99,409,122 (GRCm39) splice site probably benign
IGL02619:Armc8 APN 9 99,409,122 (GRCm39) splice site probably benign
IGL02621:Armc8 APN 9 99,409,122 (GRCm39) splice site probably benign
IGL02622:Armc8 APN 9 99,409,122 (GRCm39) splice site probably benign
IGL02623:Armc8 APN 9 99,409,122 (GRCm39) splice site probably benign
IGL02624:Armc8 APN 9 99,409,122 (GRCm39) splice site probably benign
Scrambler UTSW 9 99,378,202 (GRCm39) critical splice donor site probably null
warthog UTSW 9 99,402,538 (GRCm39) missense probably benign 0.02
D4043:Armc8 UTSW 9 99,366,029 (GRCm39) missense probably benign 0.13
R0321:Armc8 UTSW 9 99,415,230 (GRCm39) missense probably damaging 0.99
R0498:Armc8 UTSW 9 99,379,345 (GRCm39) missense probably damaging 1.00
R0646:Armc8 UTSW 9 99,387,741 (GRCm39) missense probably damaging 1.00
R0658:Armc8 UTSW 9 99,418,211 (GRCm39) splice site probably benign
R1061:Armc8 UTSW 9 99,419,784 (GRCm39) missense probably damaging 1.00
R1406:Armc8 UTSW 9 99,405,301 (GRCm39) missense probably benign 0.37
R1406:Armc8 UTSW 9 99,405,301 (GRCm39) missense probably benign 0.37
R1429:Armc8 UTSW 9 99,418,260 (GRCm39) missense possibly damaging 0.67
R1432:Armc8 UTSW 9 99,405,185 (GRCm39) splice site probably benign
R1538:Armc8 UTSW 9 99,387,343 (GRCm39) missense probably damaging 0.96
R1606:Armc8 UTSW 9 99,419,782 (GRCm39) missense probably damaging 0.98
R1817:Armc8 UTSW 9 99,418,312 (GRCm39) missense possibly damaging 0.67
R1866:Armc8 UTSW 9 99,418,333 (GRCm39) missense probably benign
R2015:Armc8 UTSW 9 99,365,158 (GRCm39) nonsense probably null
R2143:Armc8 UTSW 9 99,387,361 (GRCm39) missense probably damaging 0.99
R2251:Armc8 UTSW 9 99,384,653 (GRCm39) critical splice acceptor site probably null
R2842:Armc8 UTSW 9 99,387,734 (GRCm39) missense probably benign
R3010:Armc8 UTSW 9 99,369,966 (GRCm39) missense probably benign 0.06
R3709:Armc8 UTSW 9 99,402,550 (GRCm39) missense probably damaging 1.00
R4440:Armc8 UTSW 9 99,366,087 (GRCm39) missense probably benign 0.37
R4865:Armc8 UTSW 9 99,408,942 (GRCm39) critical splice donor site probably null
R5492:Armc8 UTSW 9 99,409,184 (GRCm39) nonsense probably null
R5606:Armc8 UTSW 9 99,418,315 (GRCm39) missense probably benign 0.23
R5639:Armc8 UTSW 9 99,378,202 (GRCm39) critical splice donor site probably null
R5693:Armc8 UTSW 9 99,378,202 (GRCm39) critical splice donor site probably null
R5694:Armc8 UTSW 9 99,378,202 (GRCm39) critical splice donor site probably null
R5698:Armc8 UTSW 9 99,417,873 (GRCm39) missense probably benign 0.12
R5700:Armc8 UTSW 9 99,378,202 (GRCm39) critical splice donor site probably null
R5701:Armc8 UTSW 9 99,378,202 (GRCm39) critical splice donor site probably null
R5735:Armc8 UTSW 9 99,379,447 (GRCm39) critical splice acceptor site probably null
R6314:Armc8 UTSW 9 99,417,937 (GRCm39) missense probably benign 0.28
R7034:Armc8 UTSW 9 99,366,018 (GRCm39) critical splice donor site probably null
R7036:Armc8 UTSW 9 99,366,018 (GRCm39) critical splice donor site probably null
R7393:Armc8 UTSW 9 99,366,052 (GRCm39) missense possibly damaging 0.47
R7395:Armc8 UTSW 9 99,415,185 (GRCm39) missense probably damaging 0.99
R7937:Armc8 UTSW 9 99,418,272 (GRCm39) missense probably damaging 0.98
R8130:Armc8 UTSW 9 99,433,600 (GRCm39) missense probably benign 0.02
R8373:Armc8 UTSW 9 99,409,152 (GRCm39) missense probably benign 0.02
R8734:Armc8 UTSW 9 99,402,538 (GRCm39) missense probably benign 0.02
R9098:Armc8 UTSW 9 99,387,362 (GRCm39) nonsense probably null
R9255:Armc8 UTSW 9 99,379,441 (GRCm39) missense possibly damaging 0.95
R9358:Armc8 UTSW 9 99,450,653 (GRCm39) critical splice donor site probably null
R9463:Armc8 UTSW 9 99,378,203 (GRCm39) critical splice donor site probably null
Z1177:Armc8 UTSW 9 99,379,439 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16