Incidental Mutation 'IGL02244:Lysmd4'
ID 286106
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lysmd4
Ensembl Gene ENSMUSG00000043831
Gene Name LysM, putative peptidoglycan-binding, domain containing 4
Synonyms 4930506D23Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # IGL02244
Quality Score
Status
Chromosome 7
Chromosomal Location 66872292-66878216 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 66875672 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 112 (S112P)
Ref Sequence ENSEMBL: ENSMUSP00000146557 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058771] [ENSMUST00000179106] [ENSMUST00000207757] [ENSMUST00000207823] [ENSMUST00000208213] [ENSMUST00000208998] [ENSMUST00000208698] [ENSMUST00000208512]
AlphaFold Q8CC84
Predicted Effect probably damaging
Transcript: ENSMUST00000058771
AA Change: S112P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000053341
Gene: ENSMUSG00000043831
AA Change: S112P

DomainStartEndE-ValueType
low complexity region 31 43 N/A INTRINSIC
LysM 72 116 3.73e-4 SMART
transmembrane domain 215 237 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179106
SMART Domains Protein: ENSMUSP00000136151
Gene: ENSMUSG00000043831

DomainStartEndE-ValueType
low complexity region 31 43 N/A INTRINSIC
LysM 72 116 3.73e-4 SMART
transmembrane domain 215 237 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181631
Predicted Effect probably benign
Transcript: ENSMUST00000207757
Predicted Effect probably benign
Transcript: ENSMUST00000207823
Predicted Effect probably benign
Transcript: ENSMUST00000208213
Predicted Effect probably damaging
Transcript: ENSMUST00000208998
AA Change: S112P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000208698
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208569
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208802
Predicted Effect probably benign
Transcript: ENSMUST00000208512
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438H23Rik G T 16: 90,853,085 (GRCm39) T17K probably benign Het
Agbl1 T C 7: 76,416,120 (GRCm39) S714P probably damaging Het
Araf A G X: 20,719,835 (GRCm39) probably benign Het
Armc3 G A 2: 19,290,948 (GRCm39) probably null Het
Armc8 A T 9: 99,365,227 (GRCm39) D638E probably benign Het
Bpifb5 C T 2: 154,067,068 (GRCm39) T107I possibly damaging Het
Ces1e A C 8: 93,938,977 (GRCm39) probably null Het
Col4a3 C A 1: 82,647,492 (GRCm39) probably benign Het
Col4a5 A G X: 140,382,669 (GRCm39) probably benign Het
Crocc T C 4: 140,765,231 (GRCm39) H477R probably benign Het
Dgkd C A 1: 87,842,863 (GRCm39) N130K probably benign Het
Dock1 C T 7: 134,379,174 (GRCm39) Q634* probably null Het
Dzip3 C T 16: 48,801,351 (GRCm39) V58I probably benign Het
Fndc3a A G 14: 72,793,807 (GRCm39) probably benign Het
Glp2r C T 11: 67,612,817 (GRCm39) R379H probably damaging Het
Kctd12b T A X: 152,472,330 (GRCm39) M120L probably benign Het
Krt33b A G 11: 99,916,189 (GRCm39) V258A probably benign Het
Lpin1 T A 12: 16,591,770 (GRCm39) N819I probably damaging Het
Lurap1l T C 4: 80,871,866 (GRCm39) S120P probably damaging Het
Myo1e A G 9: 70,274,971 (GRCm39) K708R probably benign Het
Nr3c1 T A 18: 39,554,610 (GRCm39) probably benign Het
Nup62cl G T X: 138,922,780 (GRCm39) N239K probably benign Het
Nwd1 A T 8: 73,434,210 (GRCm39) E1269V probably damaging Het
Or52e7 C T 7: 104,685,152 (GRCm39) T249M probably damaging Het
Pcdh9 A C 14: 93,564,204 (GRCm39) L1084R probably damaging Het
Plxnd1 A G 6: 115,955,218 (GRCm39) M543T probably benign Het
Prss53 T A 7: 127,487,964 (GRCm39) T173S possibly damaging Het
Reep2 C A 18: 34,973,807 (GRCm39) probably benign Het
Rp1 T C 1: 4,419,003 (GRCm39) D703G probably benign Het
Sbf2 T G 7: 110,159,502 (GRCm39) D36A probably damaging Het
Sh3kbp1 C T X: 158,586,724 (GRCm39) R99W probably damaging Het
Sis T A 3: 72,863,523 (GRCm39) R238S probably benign Het
Slc35e2 T A 4: 155,703,019 (GRCm39) V344D probably damaging Het
Specc1 G A 11: 62,019,194 (GRCm39) V678I probably benign Het
Supt6 T C 11: 78,123,623 (GRCm39) D49G possibly damaging Het
Tecpr1 G A 5: 144,146,821 (GRCm39) A515V probably benign Het
Tlr4 G A 4: 66,752,298 (GRCm39) probably null Het
Tmco5b A G 2: 113,118,619 (GRCm39) E114G probably damaging Het
Tspear A T 10: 77,688,690 (GRCm39) probably benign Het
Txlnb T A 10: 17,719,116 (GRCm39) V649E probably benign Het
Utp20 A G 10: 88,651,818 (GRCm39) probably benign Het
Virma G A 4: 11,546,031 (GRCm39) R1673Q probably damaging Het
Vmn2r70 T A 7: 85,214,211 (GRCm39) T314S probably benign Het
Zfp938 G T 10: 82,061,906 (GRCm39) T238K possibly damaging Het
Other mutations in Lysmd4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0024:Lysmd4 UTSW 7 66,875,828 (GRCm39) missense probably benign 0.03
R0317:Lysmd4 UTSW 7 66,876,045 (GRCm39) missense probably damaging 1.00
R0563:Lysmd4 UTSW 7 66,875,925 (GRCm39) missense probably benign 0.01
R0653:Lysmd4 UTSW 7 66,875,788 (GRCm39) missense probably benign 0.09
R1856:Lysmd4 UTSW 7 66,875,979 (GRCm39) missense probably benign 0.07
R7012:Lysmd4 UTSW 7 66,875,765 (GRCm39) missense probably benign 0.08
R7578:Lysmd4 UTSW 7 66,876,037 (GRCm39) nonsense probably null
R7777:Lysmd4 UTSW 7 66,873,446 (GRCm39) missense possibly damaging 0.92
R8064:Lysmd4 UTSW 7 66,873,398 (GRCm39) missense probably damaging 1.00
R8751:Lysmd4 UTSW 7 66,875,787 (GRCm39) missense probably benign 0.09
R8863:Lysmd4 UTSW 7 66,873,493 (GRCm39) missense probably damaging 0.97
Posted On 2015-04-16