Incidental Mutation 'IGL02244:Lurap1l'
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ID286107
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lurap1l
Ensembl Gene ENSMUSG00000048706
Gene Nameleucine rich adaptor protein 1-like
Synonyms1110029A09Rik, WI-13707, D4Bwg0951e
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock #IGL02244
Quality Score
Status
Chromosome4
Chromosomal Location80910646-80955628 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 80953629 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 120 (S120P)
Ref Sequence ENSEMBL: ENSMUSP00000062628 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055922]
Predicted Effect probably damaging
Transcript: ENSMUST00000055922
AA Change: S120P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000062628
Gene: ENSMUSG00000048706
AA Change: S120P

DomainStartEndE-ValueType
Pfam:LURAP 70 186 3.3e-56 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438H23Rik G T 16: 91,056,197 T17K probably benign Het
Agbl1 T C 7: 76,766,372 S714P probably damaging Het
Araf A G X: 20,853,596 probably benign Het
Armc3 G A 2: 19,286,137 probably null Het
Armc8 A T 9: 99,483,174 D638E probably benign Het
Bpifb5 C T 2: 154,225,148 T107I possibly damaging Het
Ces1e A C 8: 93,212,349 probably null Het
Col4a3 C A 1: 82,669,771 probably benign Het
Col4a5 A G X: 141,599,673 probably benign Het
Crocc T C 4: 141,037,920 H477R probably benign Het
Dgkd C A 1: 87,915,141 N130K probably benign Het
Dock1 C T 7: 134,777,445 Q634* probably null Het
Dzip3 C T 16: 48,980,988 V58I probably benign Het
Fndc3a A G 14: 72,556,367 probably benign Het
Glp2r C T 11: 67,721,991 R379H probably damaging Het
Kctd12b T A X: 153,689,334 M120L probably benign Het
Krt33b A G 11: 100,025,363 V258A probably benign Het
Lpin1 T A 12: 16,541,769 N819I probably damaging Het
Lysmd4 T C 7: 67,225,924 S112P probably damaging Het
Myo1e A G 9: 70,367,689 K708R probably benign Het
Nr3c1 T A 18: 39,421,557 probably benign Het
Nup62cl G T X: 140,022,031 N239K probably benign Het
Nwd1 A T 8: 72,707,582 E1269V probably damaging Het
Olfr676 C T 7: 105,035,945 T249M probably damaging Het
Pcdh9 A C 14: 93,326,768 L1084R probably damaging Het
Plxnd1 A G 6: 115,978,257 M543T probably benign Het
Prss53 T A 7: 127,888,792 T173S possibly damaging Het
Reep2 C A 18: 34,840,754 probably benign Het
Rp1 T C 1: 4,348,780 D703G probably benign Het
Sbf2 T G 7: 110,560,295 D36A probably damaging Het
Sh3kbp1 C T X: 159,803,728 R99W probably damaging Het
Sis T A 3: 72,956,190 R238S probably benign Het
Slc35e2 T A 4: 155,618,562 V344D probably damaging Het
Specc1 G A 11: 62,128,368 V678I probably benign Het
Supt6 T C 11: 78,232,797 D49G possibly damaging Het
Tecpr1 G A 5: 144,210,003 A515V probably benign Het
Tlr4 G A 4: 66,834,061 probably null Het
Tmco5b A G 2: 113,288,274 E114G probably damaging Het
Tspear A T 10: 77,852,856 probably benign Het
Txlnb T A 10: 17,843,368 V649E probably benign Het
Utp20 A G 10: 88,815,956 probably benign Het
Virma G A 4: 11,546,031 R1673Q probably damaging Het
Vmn2r70 T A 7: 85,565,003 T314S probably benign Het
Zfp938 G T 10: 82,226,072 T238K possibly damaging Het
Other mutations in Lurap1l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02227:Lurap1l APN 4 80953857 missense probably damaging 0.99
IGL02943:Lurap1l APN 4 80953635 missense probably damaging 1.00
R1356:Lurap1l UTSW 4 80911530 missense probably benign 0.00
R4182:Lurap1l UTSW 4 80953858 missense probably benign 0.07
R4183:Lurap1l UTSW 4 80953858 missense probably benign 0.07
R4798:Lurap1l UTSW 4 80911413 missense probably damaging 1.00
R5715:Lurap1l UTSW 4 80953721 missense possibly damaging 0.93
R7033:Lurap1l UTSW 4 80911367 missense probably benign 0.13
R7186:Lurap1l UTSW 4 80911510 missense possibly damaging 0.68
R7225:Lurap1l UTSW 4 80911481 missense probably benign 0.05
R7414:Lurap1l UTSW 4 80953754 missense probably benign
Posted On2015-04-16