Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02244:Zfp938'

286111

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp938

Ensembl Gene

ENSMUSG00000062931

Gene Name

zinc finger protein 938

Synonyms

B230315N10Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

IGL02244

Quality Score

Status

Chromosome

Chromosomal Location

82224850-82241280 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 82226072 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 238 (T238K)

Ref Sequence

ENSEMBL: ENSMUSP00000047110 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041264] [ENSMUST00000156218]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000041264
AA Change: T238K

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000047110
Gene: ENSMUSG00000062931
AA Change: T238K

Domain	Start	End	E-Value	Type
KRAB	4	64	5.28e-14	SMART
ZnF_C2H2	161	188	2.82e1	SMART
ZnF_C2H2	267	289	1.23e0	SMART
ZnF_C2H2	295	317	2.91e-2	SMART
ZnF_C2H2	323	345	2.4e-3	SMART
ZnF_C2H2	351	373	7.26e-3	SMART
ZnF_C2H2	379	401	4.65e-1	SMART
ZnF_C2H2	407	429	1.47e-3	SMART
ZnF_C2H2	435	457	5.59e-4	SMART
ZnF_C2H2	463	485	1.82e-3	SMART
ZnF_C2H2	491	513	3.63e-3	SMART
ZnF_C2H2	519	541	7.67e-2	SMART
ZnF_C2H2	547	569	2.4e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000156218

SMART Domains

Protein: ENSMUSP00000121613
Gene: ENSMUSG00000062931

Domain	Start	End	E-Value	Type
KRAB	4	64	5.28e-14	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438H23Rik	G	T	16: 91,056,197	T17K	probably benign	Het
Agbl1	T	C	7: 76,766,372	S714P	probably damaging	Het
Araf	A	G	X: 20,853,596		probably benign	Het
Armc3	G	A	2: 19,286,137		probably null	Het
Armc8	A	T	9: 99,483,174	D638E	probably benign	Het
Bpifb5	C	T	2: 154,225,148	T107I	possibly damaging	Het
Ces1e	A	C	8: 93,212,349		probably null	Het
Col4a3	C	A	1: 82,669,771		probably benign	Het
Col4a5	A	G	X: 141,599,673		probably benign	Het
Crocc	T	C	4: 141,037,920	H477R	probably benign	Het
Dgkd	C	A	1: 87,915,141	N130K	probably benign	Het
Dock1	C	T	7: 134,777,445	Q634*	probably null	Het
Dzip3	C	T	16: 48,980,988	V58I	probably benign	Het
Fndc3a	A	G	14: 72,556,367		probably benign	Het
Glp2r	C	T	11: 67,721,991	R379H	probably damaging	Het
Kctd12b	T	A	X: 153,689,334	M120L	probably benign	Het
Krt33b	A	G	11: 100,025,363	V258A	probably benign	Het
Lpin1	T	A	12: 16,541,769	N819I	probably damaging	Het
Lurap1l	T	C	4: 80,953,629	S120P	probably damaging	Het
Lysmd4	T	C	7: 67,225,924	S112P	probably damaging	Het
Myo1e	A	G	9: 70,367,689	K708R	probably benign	Het
Nr3c1	T	A	18: 39,421,557		probably benign	Het
Nup62cl	G	T	X: 140,022,031	N239K	probably benign	Het
Nwd1	A	T	8: 72,707,582	E1269V	probably damaging	Het
Olfr676	C	T	7: 105,035,945	T249M	probably damaging	Het
Pcdh9	A	C	14: 93,326,768	L1084R	probably damaging	Het
Plxnd1	A	G	6: 115,978,257	M543T	probably benign	Het
Prss53	T	A	7: 127,888,792	T173S	possibly damaging	Het
Reep2	C	A	18: 34,840,754		probably benign	Het
Rp1	T	C	1: 4,348,780	D703G	probably benign	Het
Sbf2	T	G	7: 110,560,295	D36A	probably damaging	Het
Sh3kbp1	C	T	X: 159,803,728	R99W	probably damaging	Het
Sis	T	A	3: 72,956,190	R238S	probably benign	Het
Slc35e2	T	A	4: 155,618,562	V344D	probably damaging	Het
Specc1	G	A	11: 62,128,368	V678I	probably benign	Het
Supt6	T	C	11: 78,232,797	D49G	possibly damaging	Het
Tecpr1	G	A	5: 144,210,003	A515V	probably benign	Het
Tlr4	G	A	4: 66,834,061		probably null	Het
Tmco5b	A	G	2: 113,288,274	E114G	probably damaging	Het
Tspear	A	T	10: 77,852,856		probably benign	Het
Txlnb	T	A	10: 17,843,368	V649E	probably benign	Het
Utp20	A	G	10: 88,815,956		probably benign	Het
Virma	G	A	4: 11,546,031	R1673Q	probably damaging	Het
Vmn2r70	T	A	7: 85,565,003	T314S	probably benign	Het

Other mutations in Zfp938

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00659:Zfp938	APN	10	82227521	utr 3 prime	probably benign
IGL00743:Zfp938	APN	10	82226483	missense	probably benign
IGL01764:Zfp938	APN	10	82227790	splice site	probably benign
IGL01814:Zfp938	APN	10	82226218	missense	probably benign
IGL02865:Zfp938	APN	10	82226192	missense	probably benign	0.33
R0372:Zfp938	UTSW	10	82227828	missense	probably damaging	1.00
R0666:Zfp938	UTSW	10	82225772	missense	probably damaging	1.00
R0964:Zfp938	UTSW	10	82225419	missense	probably benign	0.00
R1453:Zfp938	UTSW	10	82227798	critical splice donor site	probably null
R1672:Zfp938	UTSW	10	82225148	missense	probably benign
R1929:Zfp938	UTSW	10	82225547	missense	probably damaging	1.00
R1959:Zfp938	UTSW	10	82225631	missense	probably damaging	1.00
R2127:Zfp938	UTSW	10	82226042	missense	probably benign
R2271:Zfp938	UTSW	10	82225547	missense	probably damaging	1.00
R2900:Zfp938	UTSW	10	82225506	missense	possibly damaging	0.92
R4502:Zfp938	UTSW	10	82226271	missense	possibly damaging	0.73
R4503:Zfp938	UTSW	10	82226271	missense	possibly damaging	0.73
R4886:Zfp938	UTSW	10	82226123	missense	probably benign	0.33
R4934:Zfp938	UTSW	10	82226178	missense	possibly damaging	0.86
R5174:Zfp938	UTSW	10	82226004	missense	possibly damaging	0.53
R5410:Zfp938	UTSW	10	82225258	missense	possibly damaging	0.89
R6284:Zfp938	UTSW	10	82227566	missense	possibly damaging	0.73
R6491:Zfp938	UTSW	10	82227529	makesense	probably null
R6575:Zfp938	UTSW	10	82225326	nonsense	probably null
R6649:Zfp938	UTSW	10	82225398	missense	probably damaging	0.99
X0066:Zfp938	UTSW	10	82226097	missense	probably benign	0.33

Posted On

2015-04-16