Incidental Mutation 'IGL02244:Glp2r'
ID 286117
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Glp2r
Ensembl Gene ENSMUSG00000049928
Gene Name glucagon-like peptide 2 receptor
Synonyms GLP-2, 9530092J08Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02244
Quality Score
Status
Chromosome 11
Chromosomal Location 67554877-67661979 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 67612817 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 379 (R379H)
Ref Sequence ENSEMBL: ENSMUSP00000061560 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021289] [ENSMUST00000051765]
AlphaFold Q5IXF8
Predicted Effect probably damaging
Transcript: ENSMUST00000021289
AA Change: R210H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000021289
Gene: ENSMUSG00000049928
AA Change: R210H

DomainStartEndE-ValueType
Pfam:7tm_2 17 225 4.8e-54 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000051765
AA Change: R379H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000061560
Gene: ENSMUSG00000049928
AA Change: R379H

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:HRM 53 122 3.4e-16 PFAM
Pfam:7tm_2 137 394 1.5e-79 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]
PHENOTYPE: Mice homozygous for a null mutation display defects in Paneth cell physiology, increased small bowel bacterial loads, and increased susceptibility to small bowel injury. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438H23Rik G T 16: 90,853,085 (GRCm39) T17K probably benign Het
Agbl1 T C 7: 76,416,120 (GRCm39) S714P probably damaging Het
Araf A G X: 20,719,835 (GRCm39) probably benign Het
Armc3 G A 2: 19,290,948 (GRCm39) probably null Het
Armc8 A T 9: 99,365,227 (GRCm39) D638E probably benign Het
Bpifb5 C T 2: 154,067,068 (GRCm39) T107I possibly damaging Het
Ces1e A C 8: 93,938,977 (GRCm39) probably null Het
Col4a3 C A 1: 82,647,492 (GRCm39) probably benign Het
Col4a5 A G X: 140,382,669 (GRCm39) probably benign Het
Crocc T C 4: 140,765,231 (GRCm39) H477R probably benign Het
Dgkd C A 1: 87,842,863 (GRCm39) N130K probably benign Het
Dock1 C T 7: 134,379,174 (GRCm39) Q634* probably null Het
Dzip3 C T 16: 48,801,351 (GRCm39) V58I probably benign Het
Fndc3a A G 14: 72,793,807 (GRCm39) probably benign Het
Kctd12b T A X: 152,472,330 (GRCm39) M120L probably benign Het
Krt33b A G 11: 99,916,189 (GRCm39) V258A probably benign Het
Lpin1 T A 12: 16,591,770 (GRCm39) N819I probably damaging Het
Lurap1l T C 4: 80,871,866 (GRCm39) S120P probably damaging Het
Lysmd4 T C 7: 66,875,672 (GRCm39) S112P probably damaging Het
Myo1e A G 9: 70,274,971 (GRCm39) K708R probably benign Het
Nr3c1 T A 18: 39,554,610 (GRCm39) probably benign Het
Nup62cl G T X: 138,922,780 (GRCm39) N239K probably benign Het
Nwd1 A T 8: 73,434,210 (GRCm39) E1269V probably damaging Het
Or52e7 C T 7: 104,685,152 (GRCm39) T249M probably damaging Het
Pcdh9 A C 14: 93,564,204 (GRCm39) L1084R probably damaging Het
Plxnd1 A G 6: 115,955,218 (GRCm39) M543T probably benign Het
Prss53 T A 7: 127,487,964 (GRCm39) T173S possibly damaging Het
Reep2 C A 18: 34,973,807 (GRCm39) probably benign Het
Rp1 T C 1: 4,419,003 (GRCm39) D703G probably benign Het
Sbf2 T G 7: 110,159,502 (GRCm39) D36A probably damaging Het
Sh3kbp1 C T X: 158,586,724 (GRCm39) R99W probably damaging Het
Sis T A 3: 72,863,523 (GRCm39) R238S probably benign Het
Slc35e2 T A 4: 155,703,019 (GRCm39) V344D probably damaging Het
Specc1 G A 11: 62,019,194 (GRCm39) V678I probably benign Het
Supt6 T C 11: 78,123,623 (GRCm39) D49G possibly damaging Het
Tecpr1 G A 5: 144,146,821 (GRCm39) A515V probably benign Het
Tlr4 G A 4: 66,752,298 (GRCm39) probably null Het
Tmco5b A G 2: 113,118,619 (GRCm39) E114G probably damaging Het
Tspear A T 10: 77,688,690 (GRCm39) probably benign Het
Txlnb T A 10: 17,719,116 (GRCm39) V649E probably benign Het
Utp20 A G 10: 88,651,818 (GRCm39) probably benign Het
Virma G A 4: 11,546,031 (GRCm39) R1673Q probably damaging Het
Vmn2r70 T A 7: 85,214,211 (GRCm39) T314S probably benign Het
Zfp938 G T 10: 82,061,906 (GRCm39) T238K possibly damaging Het
Other mutations in Glp2r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01018:Glp2r APN 11 67,600,470 (GRCm39) missense probably benign
IGL02484:Glp2r APN 11 67,630,992 (GRCm39) missense possibly damaging 0.90
R0013:Glp2r UTSW 11 67,600,538 (GRCm39) missense possibly damaging 0.88
R0013:Glp2r UTSW 11 67,600,538 (GRCm39) missense possibly damaging 0.88
R0195:Glp2r UTSW 11 67,600,534 (GRCm39) missense probably damaging 0.99
R1612:Glp2r UTSW 11 67,633,033 (GRCm39) missense possibly damaging 0.46
R1699:Glp2r UTSW 11 67,648,367 (GRCm39) missense probably benign 0.09
R1944:Glp2r UTSW 11 67,637,618 (GRCm39) missense probably benign 0.01
R3971:Glp2r UTSW 11 67,637,641 (GRCm39) missense possibly damaging 0.65
R4417:Glp2r UTSW 11 67,555,342 (GRCm39) intron probably benign
R4681:Glp2r UTSW 11 67,621,453 (GRCm39) splice site probably null
R4914:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4918:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4938:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4940:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4941:Glp2r UTSW 11 67,637,529 (GRCm39) splice site probably null
R4963:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R4966:Glp2r UTSW 11 67,648,419 (GRCm39) nonsense probably null
R5023:Glp2r UTSW 11 67,631,858 (GRCm39) missense possibly damaging 0.82
R5121:Glp2r UTSW 11 67,612,926 (GRCm39) splice site probably null
R5313:Glp2r UTSW 11 67,648,357 (GRCm39) missense probably damaging 0.96
R5705:Glp2r UTSW 11 67,600,565 (GRCm39) missense probably benign 0.30
R5790:Glp2r UTSW 11 67,655,625 (GRCm39) missense probably damaging 1.00
R6074:Glp2r UTSW 11 67,637,640 (GRCm39) missense unknown
R6595:Glp2r UTSW 11 67,655,603 (GRCm39) missense probably benign 0.10
R6910:Glp2r UTSW 11 67,621,497 (GRCm39) missense probably benign 0.28
R7511:Glp2r UTSW 11 67,648,417 (GRCm39) missense probably damaging 0.98
R7627:Glp2r UTSW 11 67,637,589 (GRCm39) missense unknown
R7681:Glp2r UTSW 11 67,600,505 (GRCm39) missense probably benign 0.45
R7779:Glp2r UTSW 11 67,600,609 (GRCm39) nonsense probably null
R8743:Glp2r UTSW 11 67,612,901 (GRCm39) missense probably damaging 0.98
R8841:Glp2r UTSW 11 67,653,555 (GRCm39) missense probably damaging 1.00
R9093:Glp2r UTSW 11 67,621,459 (GRCm39) nonsense probably null
R9380:Glp2r UTSW 11 67,637,572 (GRCm39) missense possibly damaging 0.67
R9576:Glp2r UTSW 11 67,655,622 (GRCm39) missense probably benign 0.01
R9733:Glp2r UTSW 11 67,648,367 (GRCm39) missense probably benign 0.09
Z1186:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1186:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1186:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,630,949 (GRCm39) missense probably benign 0.03
Z1186:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1186:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1186:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1187:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1187:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1187:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1188:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1188:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1188:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1188:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1189:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1189:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1189:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1189:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1190:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,630,949 (GRCm39) missense probably benign 0.03
Z1190:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1190:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1190:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1190:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1191:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,630,993 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1191:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Z1191:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1192:Glp2r UTSW 11 67,661,662 (GRCm39) missense probably benign 0.01
Z1192:Glp2r UTSW 11 67,635,773 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,633,129 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,631,885 (GRCm39) missense probably benign 0.00
Z1192:Glp2r UTSW 11 67,631,878 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,600,472 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,600,470 (GRCm39) missense probably benign
Z1192:Glp2r UTSW 11 67,600,394 (GRCm39) missense probably damaging 0.98
Posted On 2015-04-16