Incidental Mutation 'IGL02245:3425401B19Rik'
ID286155
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol 3425401B19Rik
Ensembl Gene ENSMUSG00000071540
Gene NameRIKEN cDNA 3425401B19 gene
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.104) question?
Stock #IGL02245
Quality Score
Status
Chromosome14
Chromosomal Location32659119-32685293 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 32659815 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 1398 (I1398V)
Ref Sequence ENSEMBL: ENSMUSP00000093741 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096038]
Predicted Effect probably benign
Transcript: ENSMUST00000096038
AA Change: I1398V

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000093741
Gene: ENSMUSG00000071540
AA Change: I1398V

DomainStartEndE-ValueType
low complexity region 135 145 N/A INTRINSIC
low complexity region 162 175 N/A INTRINSIC
low complexity region 386 399 N/A INTRINSIC
low complexity region 587 602 N/A INTRINSIC
low complexity region 605 624 N/A INTRINSIC
low complexity region 728 744 N/A INTRINSIC
low complexity region 1002 1015 N/A INTRINSIC
low complexity region 1086 1097 N/A INTRINSIC
low complexity region 1147 1158 N/A INTRINSIC
low complexity region 1161 1176 N/A INTRINSIC
Pfam:DUF4585 1251 1322 6.5e-30 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca5 G A 11: 110,298,169 Q821* probably null Het
Bcl9 A T 3: 97,208,693 L895Q probably damaging Het
Cpne7 A G 8: 123,117,618 D41G probably damaging Het
Daxx A G 17: 33,912,377 probably benign Het
Dbx2 A G 15: 95,624,747 Y360H probably damaging Het
Dpy19l2 T C 9: 24,696,025 T47A probably benign Het
Ephb3 T C 16: 21,221,424 V512A probably benign Het
Exoc2 T C 13: 30,906,859 D254G probably benign Het
Gtpbp1 G T 15: 79,690,926 R7L probably benign Het
Gucy2c A T 6: 136,729,203 I500N probably benign Het
Hist1h2ac A T 13: 23,683,800 Y40N probably damaging Het
Hist1h2ac G T 13: 23,683,801 N39K possibly damaging Het
Hormad2 T C 11: 4,408,580 probably benign Het
Impg2 A G 16: 56,269,082 Q1130R probably damaging Het
Itga4 T A 2: 79,320,559 D836E probably benign Het
Loxhd1 A T 18: 77,340,101 T456S possibly damaging Het
Lyst G A 13: 13,660,956 C1741Y probably benign Het
Map1b T C 13: 99,431,528 T1562A unknown Het
Mre11a C T 9: 14,815,276 probably benign Het
Myh1 A C 11: 67,211,487 E868A possibly damaging Het
Nlrp4e T G 7: 23,320,875 S262R probably damaging Het
Nlrp9a C T 7: 26,557,893 T223I probably benign Het
Nosip A G 7: 45,074,042 D44G probably benign Het
Nr6a1 C T 2: 38,740,553 M217I probably benign Het
Numa1 A G 7: 102,000,394 T1111A probably benign Het
Olfr804 T A 10: 129,705,739 I287N probably damaging Het
Pms1 A G 1: 53,207,360 L340P probably damaging Het
Prmt7 T C 8: 106,237,305 V277A probably benign Het
Pxmp4 T C 2: 154,587,950 Y173C probably damaging Het
Rbm11 G T 16: 75,593,008 V21L possibly damaging Het
Rims1 A G 1: 22,346,488 S1123P probably damaging Het
Rnf220 C T 4: 117,299,537 probably benign Het
Rnf41 T G 10: 128,437,327 *123G probably null Het
Samhd1 C T 2: 157,110,555 D426N possibly damaging Het
Scn10a A G 9: 119,672,152 W189R probably damaging Het
Slco1a6 A G 6: 142,109,424 F265L probably damaging Het
Spag16 A G 1: 69,858,502 D137G probably benign Het
Srsf12 G A 4: 33,209,103 probably benign Het
Suclg2 A G 6: 95,595,741 I81T possibly damaging Het
Tmc1 C T 19: 20,799,192 R601H probably damaging Het
Trim33 T C 3: 103,346,770 probably null Het
Vit A G 17: 78,625,051 D529G probably damaging Het
Wbp1l C T 19: 46,654,618 H353Y possibly damaging Het
Wdr70 A T 15: 8,046,482 V170D possibly damaging Het
Ythdc2 T A 18: 44,862,684 I947N possibly damaging Het
Zfp280b T C 10: 76,039,363 S359P probably benign Het
Zfp936 T C 7: 43,187,298 probably null Het
Zscan4d T A 7: 11,162,789 Y218F probably benign Het
Other mutations in 3425401B19Rik
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00839:3425401B19Rik APN 14 32660916 missense probably benign 0.18
IGL00844:3425401B19Rik APN 14 32662999 nonsense probably null
IGL01292:3425401B19Rik APN 14 32660874 missense probably benign 0.18
IGL01295:3425401B19Rik APN 14 32661936 missense possibly damaging 0.53
IGL01457:3425401B19Rik APN 14 32660951 missense probably benign
IGL01470:3425401B19Rik APN 14 32660457 missense possibly damaging 0.53
IGL01612:3425401B19Rik APN 14 32660031 missense possibly damaging 0.53
IGL01974:3425401B19Rik APN 14 32659805 missense possibly damaging 0.85
IGL02095:3425401B19Rik APN 14 32661626 missense probably benign 0.33
IGL02138:3425401B19Rik APN 14 32662715 missense possibly damaging 0.83
IGL02178:3425401B19Rik APN 14 32662461 missense possibly damaging 0.83
IGL02529:3425401B19Rik APN 14 32661233 missense probably benign
IGL03401:3425401B19Rik APN 14 32662266 nonsense probably null
PIT4515001:3425401B19Rik UTSW 14 32661111 nonsense probably null
R0233:3425401B19Rik UTSW 14 32663373 missense probably benign
R0233:3425401B19Rik UTSW 14 32663373 missense probably benign
R0320:3425401B19Rik UTSW 14 32662614 missense probably benign 0.19
R0519:3425401B19Rik UTSW 14 32662962 missense possibly damaging 0.92
R0551:3425401B19Rik UTSW 14 32662641 missense probably benign 0.03
R0759:3425401B19Rik UTSW 14 32662497 missense possibly damaging 0.93
R0831:3425401B19Rik UTSW 14 32662271 missense probably benign 0.01
R1124:3425401B19Rik UTSW 14 32662082 missense possibly damaging 0.53
R1346:3425401B19Rik UTSW 14 32660814 missense probably benign 0.07
R1997:3425401B19Rik UTSW 14 32660048 missense possibly damaging 0.71
R2055:3425401B19Rik UTSW 14 32662551 missense probably benign
R2212:3425401B19Rik UTSW 14 32661602 missense probably benign 0.33
R2416:3425401B19Rik UTSW 14 32663834 missense probably benign 0.04
R2441:3425401B19Rik UTSW 14 32663492 missense possibly damaging 0.53
R2513:3425401B19Rik UTSW 14 32661852 missense possibly damaging 0.53
R3414:3425401B19Rik UTSW 14 32661602 missense probably benign 0.33
R3800:3425401B19Rik UTSW 14 32663068 missense possibly damaging 0.83
R3809:3425401B19Rik UTSW 14 32663693 missense possibly damaging 0.96
R4166:3425401B19Rik UTSW 14 32660955 missense possibly damaging 0.53
R4581:3425401B19Rik UTSW 14 32661871 missense possibly damaging 0.73
R4721:3425401B19Rik UTSW 14 32663150 missense probably benign 0.01
R4769:3425401B19Rik UTSW 14 32660217 missense probably benign 0.32
R4809:3425401B19Rik UTSW 14 32662631 missense probably benign 0.19
R4919:3425401B19Rik UTSW 14 32663288 missense possibly damaging 0.85
R4925:3425401B19Rik UTSW 14 32663180 missense possibly damaging 0.86
R4972:3425401B19Rik UTSW 14 32661404 missense possibly damaging 0.73
R5068:3425401B19Rik UTSW 14 32661792 missense possibly damaging 0.73
R5069:3425401B19Rik UTSW 14 32661792 missense possibly damaging 0.73
R5070:3425401B19Rik UTSW 14 32661792 missense possibly damaging 0.73
R5258:3425401B19Rik UTSW 14 32663309 missense probably damaging 0.98
R5435:3425401B19Rik UTSW 14 32661456 missense probably benign 0.18
R5549:3425401B19Rik UTSW 14 32663036 missense possibly damaging 0.68
R5678:3425401B19Rik UTSW 14 32662053 missense probably damaging 0.97
R5680:3425401B19Rik UTSW 14 32662053 missense probably damaging 0.97
R5872:3425401B19Rik UTSW 14 32660352 missense possibly damaging 0.73
R5896:3425401B19Rik UTSW 14 32661675 nonsense probably null
R5940:3425401B19Rik UTSW 14 32662688 missense possibly damaging 0.91
R6044:3425401B19Rik UTSW 14 32660657 missense possibly damaging 0.53
R6136:3425401B19Rik UTSW 14 32662282 missense possibly damaging 0.70
R6277:3425401B19Rik UTSW 14 32663694 missense possibly damaging 0.86
R6385:3425401B19Rik UTSW 14 32661279 missense probably benign 0.01
R6728:3425401B19Rik UTSW 14 32662688 missense possibly damaging 0.91
R6984:3425401B19Rik UTSW 14 32661980 missense probably benign 0.00
R7047:3425401B19Rik UTSW 14 32660174 missense possibly damaging 0.89
R7249:3425401B19Rik UTSW 14 32663314 missense possibly damaging 0.73
R7493:3425401B19Rik UTSW 14 32663300 missense possibly damaging 0.96
R7575:3425401B19Rik UTSW 14 32662632 missense probably benign 0.03
R7742:3425401B19Rik UTSW 14 32662757 missense possibly damaging 0.68
R7747:3425401B19Rik UTSW 14 32663069 missense possibly damaging 0.83
R7784:3425401B19Rik UTSW 14 32659840 missense probably benign 0.00
X0025:3425401B19Rik UTSW 14 32662469 missense probably damaging 0.98
Posted On2015-04-16