Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02247:Nynrin'

286230

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Nynrin

Ensembl Gene

ENSMUSG00000075592

Gene Name

NYN domain and retroviral integrase containing

Synonyms

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02247

Quality Score

Status

Chromosome

Chromosomal Location

55854010-55874736 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 55871710 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 1425 (Q1425*)

Ref Sequence

ENSEMBL: ENSMUSP00000129557 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000100529] [ENSMUST00000168479]

Predicted Effect

probably null
Transcript: ENSMUST00000100529
AA Change: Q1425*

SMART Domains

Protein: ENSMUSP00000098098
Gene: ENSMUSG00000075592
AA Change: Q1425*

Domain	Start	End	E-Value	Type
low complexity region	581	606	N/A	INTRINSIC
Pfam:RNase_Zc3h12a	739	890	1.6e-54	PFAM
low complexity region	938	952	N/A	INTRINSIC
low complexity region	1212	1228	N/A	INTRINSIC
low complexity region	1390	1397	N/A	INTRINSIC
PDB:3S3O\|B	1478	1706	6e-8	PDB
SCOP:d1cxqa_	1552	1646	2e-12	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000168479
AA Change: Q1425*

SMART Domains

Protein: ENSMUSP00000129557
Gene: ENSMUSG00000075592
AA Change: Q1425*

Domain	Start	End	E-Value	Type
low complexity region	581	606	N/A	INTRINSIC
Pfam:RNase_Zc3h12a	739	890	5.5e-54	PFAM
low complexity region	938	952	N/A	INTRINSIC
low complexity region	1212	1228	N/A	INTRINSIC
low complexity region	1390	1397	N/A	INTRINSIC
PDB:3S3O\|B	1478	1706	6e-8	PDB
SCOP:d1cxqa_	1552	1646	2e-12	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181218

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamtsl2	A	G	2: 27,084,893	R177G	probably damaging	Het
Ap3b1	T	C	13: 94,394,795		probably null	Het
Ascc3	A	C	10: 50,650,590	K595T	probably damaging	Het
Cnpy4	A	G	5: 138,192,863	T234A	probably benign	Het
Col13a1	T	C	10: 61,961,345	Y101C	probably damaging	Het
Crybg3	A	G	16: 59,503,150	I2809T	probably damaging	Het
Csgalnact1	C	A	8: 68,401,492	G219V	probably damaging	Het
Dgkz	T	C	2: 91,937,460	S824G	probably benign	Het
Dsg1c	T	A	18: 20,264,316	I27N	probably damaging	Het
Efhb	C	T	17: 53,401,624	V673I	probably benign	Het
Egr1	T	C	18: 34,862,863	Y233H	possibly damaging	Het
Fam184a	T	C	10: 53,675,160	E237G	probably damaging	Het
Galt	A	G	4: 41,755,623		probably benign	Het
Gm4795	T	C	10: 45,007,115		noncoding transcript	Het
Gm6563	G	A	19: 23,676,028	E61K	possibly damaging	Het
Igkv1-133	G	A	6: 67,725,606	V103M	probably damaging	Het
Iqcb1	T	A	16: 36,839,896	H140Q	probably benign	Het
Itpk1	G	T	12: 102,623,409	P74Q	probably damaging	Het
Itpr3	T	A	17: 27,098,179	W803R	probably damaging	Het
Lgr4	A	T	2: 110,002,501	D312V	probably benign	Het
Lgr4	C	T	2: 110,008,075		probably benign	Het
Lyst	G	A	13: 13,660,956	C1741Y	probably benign	Het
Mllt6	C	A	11: 97,670,332	A282E	probably benign	Het
Mtif2	T	C	11: 29,540,642	S449P	possibly damaging	Het
Nrg3	T	C	14: 38,371,312	I533M	probably damaging	Het
Olfr1148	A	G	2: 87,833,529	I163M	probably damaging	Het
Olfr1184	C	T	2: 88,487,427	H232Y	probably benign	Het
Olfr1469	T	A	19: 13,411,467	S299R	probably benign	Het
Olfr397	A	T	11: 73,964,862	M85L	probably benign	Het
Olfr679	T	A	7: 105,086,323	Y202*	probably null	Het
Olfr733	T	A	14: 50,299,114	N65I	probably damaging	Het
Olfr869	G	A	9: 20,137,220	V35I	probably benign	Het
Plcb4	C	T	2: 135,994,325	T20I	possibly damaging	Het
Ppp1r12b	G	T	1: 134,835,983	T771K	probably benign	Het
Prss22	T	C	17: 23,996,389	T138A	probably benign	Het
Ros1	A	T	10: 52,129,581	S907T	probably damaging	Het
Rtel1	T	A	2: 181,351,341	Y521*	probably null	Het
Sacs	T	C	14: 61,192,535	F678S	probably damaging	Het
Smtnl1	A	T	2: 84,817,028		probably benign	Het
Sumf2	T	C	5: 129,860,145	V258A	probably damaging	Het
Tas1r2	A	T	4: 139,669,516	Y722F	probably damaging	Het
Tecpr1	A	G	5: 144,206,554	F668L	possibly damaging	Het
Timd4	T	C	11: 46,815,731	F120S	probably damaging	Het
Tnnt3	T	C	7: 142,508,325		probably benign	Het
Trp53bp1	G	A	2: 121,236,589	S552F	probably damaging	Het
Txlnb	G	A	10: 17,830,342	R333Q	possibly damaging	Het
Txlnb	A	G	10: 17,841,528		probably benign	Het
Uroc1	A	G	6: 90,347,928	E461G	probably benign	Het
Vps45	G	A	3: 96,042,924	T231I	probably damaging	Het
Zfp648	T	A	1: 154,204,177	S27R	probably benign	Het

Other mutations in Nynrin

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01020:Nynrin	APN	14	55868448	missense	probably benign	0.38
IGL01131:Nynrin	APN	14	55872685	missense	probably damaging	1.00
IGL01357:Nynrin	APN	14	55870417	missense	probably benign
IGL01537:Nynrin	APN	14	55872045	missense	possibly damaging	0.87
IGL01583:Nynrin	APN	14	55870511	missense	probably damaging	1.00
IGL01726:Nynrin	APN	14	55864154	missense	probably benign
IGL02161:Nynrin	APN	14	55863984	missense	probably damaging	1.00
IGL02167:Nynrin	APN	14	55863335	missense	probably damaging	1.00
IGL02302:Nynrin	APN	14	55868505	missense	probably benign	0.43
IGL02524:Nynrin	APN	14	55871474	missense	possibly damaging	0.73
IGL02600:Nynrin	APN	14	55863992	missense	probably benign	0.38
IGL02639:Nynrin	APN	14	55870655	missense	probably damaging	1.00
IGL02654:Nynrin	APN	14	55863259	missense	possibly damaging	0.95
IGL02659:Nynrin	APN	14	55866097	unclassified	probably benign
IGL02736:Nynrin	APN	14	55870909	missense	probably damaging	1.00
IGL02949:Nynrin	APN	14	55872380	missense	probably damaging	0.99
PIT4458001:Nynrin	UTSW	14	55863968	missense	probably benign	0.39
R0017:Nynrin	UTSW	14	55872395	missense	probably damaging	1.00
R0078:Nynrin	UTSW	14	55863332	missense	probably damaging	1.00
R0211:Nynrin	UTSW	14	55871798	missense	probably benign	0.08
R0211:Nynrin	UTSW	14	55871798	missense	probably benign	0.08
R0413:Nynrin	UTSW	14	55872191	missense	possibly damaging	0.90
R0609:Nynrin	UTSW	14	55872761	missense	probably damaging	1.00
R0626:Nynrin	UTSW	14	55868035	missense	probably damaging	1.00
R1205:Nynrin	UTSW	14	55854189	intron	probably benign
R1222:Nynrin	UTSW	14	55863541	missense	probably benign	0.02
R1385:Nynrin	UTSW	14	55864899	missense	probably benign	0.00
R1820:Nynrin	UTSW	14	55870378	missense	possibly damaging	0.95
R1829:Nynrin	UTSW	14	55872947	missense	possibly damaging	0.50
R1874:Nynrin	UTSW	14	55863493	missense	probably benign	0.04
R1927:Nynrin	UTSW	14	55863592	missense	probably benign	0.00
R2233:Nynrin	UTSW	14	55872067	missense	possibly damaging	0.83
R3018:Nynrin	UTSW	14	55863410	missense	probably benign	0.00
R3154:Nynrin	UTSW	14	55863587	missense	possibly damaging	0.46
R3853:Nynrin	UTSW	14	55864105	missense	probably benign	0.24
R4648:Nynrin	UTSW	14	55872894	nonsense	probably null
R4722:Nynrin	UTSW	14	55854395	missense	probably damaging	0.97
R4735:Nynrin	UTSW	14	55870168	missense	probably benign	0.03
R4736:Nynrin	UTSW	14	55863997	missense	probably damaging	1.00
R4780:Nynrin	UTSW	14	55863263	missense	probably damaging	1.00
R4804:Nynrin	UTSW	14	55864869	missense	probably benign
R4816:Nynrin	UTSW	14	55872001	missense	probably damaging	1.00
R5307:Nynrin	UTSW	14	55863806	missense	probably damaging	1.00
R5372:Nynrin	UTSW	14	55868491	missense	probably benign	0.01
R5432:Nynrin	UTSW	14	55864466	missense	possibly damaging	0.80
R5800:Nynrin	UTSW	14	55870631	missense	probably damaging	1.00
R5825:Nynrin	UTSW	14	55864226	missense	probably benign	0.00
R6149:Nynrin	UTSW	14	55854323	missense	possibly damaging	0.83
R6244:Nynrin	UTSW	14	55868028	missense	probably damaging	1.00
R6350:Nynrin	UTSW	14	55868076	missense	probably benign	0.19
R6379:Nynrin	UTSW	14	55870391	missense	probably damaging	1.00
R6437:Nynrin	UTSW	14	55871770	missense	probably benign	0.00
R6501:Nynrin	UTSW	14	55863532	missense	probably benign
R6702:Nynrin	UTSW	14	55864478	missense	possibly damaging	0.80
R6703:Nynrin	UTSW	14	55864478	missense	possibly damaging	0.80
R6907:Nynrin	UTSW	14	55863878	missense	probably benign	0.20
R6908:Nynrin	UTSW	14	55863878	missense	probably benign	0.20
R6928:Nynrin	UTSW	14	55863878	missense	probably benign	0.20
R6934:Nynrin	UTSW	14	55863878	missense	probably benign	0.20
R6935:Nynrin	UTSW	14	55863878	missense	probably benign	0.20
R7197:Nynrin	UTSW	14	55871923	missense	probably benign	0.00
R7204:Nynrin	UTSW	14	55872733	missense	probably damaging	1.00
R7272:Nynrin	UTSW	14	55870415	missense	probably damaging	1.00
R7335:Nynrin	UTSW	14	55863914	missense	probably benign
R7361:Nynrin	UTSW	14	55870400	missense	possibly damaging	0.71
R7368:Nynrin	UTSW	14	55870511	missense	probably damaging	1.00
R7443:Nynrin	UTSW	14	55871416	missense	probably benign	0.18
R7584:Nynrin	UTSW	14	55871584	missense	probably damaging	1.00
R7677:Nynrin	UTSW	14	55870236	missense	probably benign
R7723:Nynrin	UTSW	14	55872045	missense	possibly damaging	0.87
R7776:Nynrin	UTSW	14	55865963	missense	probably damaging	1.00
R7787:Nynrin	UTSW	14	55870523	missense	probably benign
R7842:Nynrin	UTSW	14	55865096	missense	probably damaging	1.00
R7852:Nynrin	UTSW	14	55871429	missense	probably damaging	0.96
R8040:Nynrin	UTSW	14	55871525	missense	probably benign	0.01
R8159:Nynrin	UTSW	14	55863130	missense	probably damaging	0.99
R8159:Nynrin	UTSW	14	55865060	missense	probably benign
R8258:Nynrin	UTSW	14	55863358	missense	possibly damaging	0.95
R8259:Nynrin	UTSW	14	55863358	missense	possibly damaging	0.95
R8343:Nynrin	UTSW	14	55863791	missense	probably benign
R8504:Nynrin	UTSW	14	55870246	missense	probably benign	0.01
RF007:Nynrin	UTSW	14	55866201	splice site	probably null

Posted On

2015-04-16