Incidental Mutation 'IGL02249:Klra10'
ID286295
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Klra10
Ensembl Gene ENSMUSG00000072718
Gene Namekiller cell lectin-like receptor subfamily A, member 10
SynonymsLy49i2, Ly49J
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL02249
Quality Score
Status
Chromosome6
Chromosomal Location130269194-130281928 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 130279404 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Tyrosine at position 96 (N96Y)
Ref Sequence ENSEMBL: ENSMUSP00000107651 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112020]
Predicted Effect probably benign
Transcript: ENSMUST00000112020
AA Change: N96Y

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000107651
Gene: ENSMUSG00000072718
AA Change: N96Y

DomainStartEndE-ValueType
low complexity region 56 66 N/A INTRINSIC
Blast:CLECT 73 117 2e-9 BLAST
CLECT 143 258 6.43e-14 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700019A02Rik T A 1: 53,185,272 K23* probably null Het
Abca1 A T 4: 53,068,739 L1333* probably null Het
Adcy6 C A 15: 98,599,914 M452I probably damaging Het
Adsl G A 15: 80,960,475 R173H probably benign Het
Ank3 A G 10: 69,882,370 T484A probably damaging Het
Apol10a A G 15: 77,488,509 D115G probably damaging Het
Bard1 A G 1: 71,053,669 S529P probably damaging Het
C2 A G 17: 34,864,508 probably benign Het
Cftr T A 6: 18,277,871 I956N possibly damaging Het
Cwc15 A G 9: 14,503,681 T110A probably benign Het
Dsg4 A T 18: 20,461,304 I497F possibly damaging Het
Gadd45b A G 10: 80,931,133 D69G possibly damaging Het
Glb1l3 A T 9: 26,831,268 S307R possibly damaging Het
Greb1l G A 18: 10,532,961 G843R probably damaging Het
H2-M11 A T 17: 36,547,937 Y123F probably benign Het
Hal G A 10: 93,497,538 A323T probably damaging Het
Il4ra T C 7: 125,567,224 F47L probably benign Het
Mki67 T A 7: 135,700,522 M928L possibly damaging Het
Myh15 T A 16: 49,110,484 V607D probably damaging Het
Ndufaf2 A G 13: 108,081,391 W74R probably damaging Het
Noc4l C A 5: 110,653,215 probably benign Het
Olfr623 T A 7: 103,660,366 I295F probably damaging Het
Papss1 T A 3: 131,602,011 W274R probably damaging Het
Pax3 C T 1: 78,195,325 V83I probably damaging Het
Prmt5 C T 14: 54,509,865 R485H probably damaging Het
Ptprq A G 10: 107,582,359 Y1719H probably damaging Het
Ranbp2 A T 10: 58,480,078 I2207F possibly damaging Het
Rock2 T A 12: 16,971,041 probably benign Het
Sema3c G A 5: 17,662,963 R124H probably damaging Het
Serpina1e G A 12: 103,951,134 T92M probably benign Het
Sgip1 T C 4: 102,911,470 L83P probably benign Het
Tm9sf2 C T 14: 122,123,750 S68L probably damaging Het
Tmem178 A G 17: 80,989,806 T206A probably damaging Het
Tmem207 A T 16: 26,517,867 Y46N possibly damaging Het
Tmem57 T C 4: 134,828,312 I283M possibly damaging Het
Tyk2 A G 9: 21,120,407 L429P probably damaging Het
Other mutations in Klra10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01505:Klra10 APN 6 130272717 missense probably damaging 1.00
IGL02060:Klra10 APN 6 130272725 missense probably damaging 0.99
IGL02681:Klra10 APN 6 130279419 missense probably damaging 0.98
IGL02684:Klra10 APN 6 130281882 missense possibly damaging 0.85
FR4342:Klra10 UTSW 6 130272747 missense probably benign 0.01
R0324:Klra10 UTSW 6 130272650 splice site probably null
R1072:Klra10 UTSW 6 130281848 missense probably benign 0.11
R1466:Klra10 UTSW 6 130279315 missense probably damaging 1.00
R1466:Klra10 UTSW 6 130279431 missense probably damaging 0.98
R1466:Klra10 UTSW 6 130279315 missense probably damaging 1.00
R1466:Klra10 UTSW 6 130279431 missense probably damaging 0.98
R2125:Klra10 UTSW 6 130279278 missense probably damaging 0.98
R2266:Klra10 UTSW 6 130269301 missense probably benign 0.13
R2427:Klra10 UTSW 6 130279335 missense probably benign 0.00
R4260:Klra10 UTSW 6 130272681 missense probably damaging 1.00
R4495:Klra10 UTSW 6 130279348 missense probably benign 0.00
R5897:Klra10 UTSW 6 130281829 nonsense probably null
R6123:Klra10 UTSW 6 130279376 missense probably benign 0.04
R6221:Klra10 UTSW 6 130269272 missense probably benign
R6478:Klra10 UTSW 6 130272544 intron probably null
R6520:Klra10 UTSW 6 130275792 missense probably benign 0.03
R6551:Klra10 UTSW 6 130275755 missense probably benign 0.36
R7445:Klra10 UTSW 6 130275856 missense probably benign 0.38
R7453:Klra10 UTSW 6 130280364 missense probably damaging 0.98
R7744:Klra10 UTSW 6 130272761 critical splice acceptor site probably null
R8079:Klra10 UTSW 6 130275775 missense probably benign
RF060:Klra10 UTSW 6 130275821 small deletion probably benign
Posted On2015-04-16