Incidental Mutation 'IGL00971:Wap'
ID 28631
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wap
Ensembl Gene ENSMUSG00000000381
Gene Name whey acidic protein
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00971
Quality Score
Status
Chromosome 11
Chromosomal Location 6585482-6588637 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 6586808 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 97 (C97F)
Ref Sequence ENSEMBL: ENSMUSP00000099974 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102910]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000102910
AA Change: C97F

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000099974
Gene: ENSMUSG00000000381
AA Change: C97F

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
internal_repeat_1 46 75 4.46e-5 PROSPERO
WAP 79 128 1.96e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127341
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141868
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutants are phenotypically normal and fertile. Functional differentiation of mammary epithelium is normal and dams produce milk, but pups thrive poorly on milk lacking whey acidic protein. A normal variant determines a one amino acid change inWAP protein in YBR versus other strains. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930596D02Rik C T 14: 35,532,170 (GRCm39) C135Y possibly damaging Het
Afdn T A 17: 14,072,575 (GRCm39) probably benign Het
Akap10 A G 11: 61,795,622 (GRCm39) V347A possibly damaging Het
Ankrd11 A G 8: 123,622,092 (GRCm39) S587P probably damaging Het
Ces1g T C 8: 94,029,660 (GRCm39) Y524C probably damaging Het
Cimip2b A G 4: 43,428,377 (GRCm39) L51P probably damaging Het
Cubn T C 2: 13,283,219 (GRCm39) N3573S possibly damaging Het
Cyp1a1 G T 9: 57,607,990 (GRCm39) C206F probably damaging Het
Fbxo30 T C 10: 11,166,042 (GRCm39) Y255H probably benign Het
Ggnbp2 T C 11: 84,731,230 (GRCm39) I295V possibly damaging Het
Gpatch8 A G 11: 102,370,743 (GRCm39) Y932H unknown Het
Gvin-ps3 G A 7: 105,681,008 (GRCm39) noncoding transcript Het
Heatr6 C T 11: 83,650,135 (GRCm39) P197L probably damaging Het
Helb T C 10: 119,930,168 (GRCm39) D737G possibly damaging Het
Helz A T 11: 107,554,479 (GRCm39) I1226F possibly damaging Het
Ipo11 A T 13: 106,993,277 (GRCm39) I749N probably damaging Het
Ipo13 T C 4: 117,771,564 (GRCm39) E2G possibly damaging Het
Jam3 A C 9: 27,013,188 (GRCm39) D127E probably damaging Het
Kif16b G T 2: 142,553,664 (GRCm39) Q1045K probably benign Het
Kin T C 2: 10,095,159 (GRCm39) W121R possibly damaging Het
Man1b1 T G 2: 25,233,337 (GRCm39) S237A possibly damaging Het
Mmel1 C T 4: 154,972,289 (GRCm39) probably benign Het
Morn4 T C 19: 42,064,559 (GRCm39) N143S possibly damaging Het
Nlrp4b A G 7: 10,448,882 (GRCm39) T362A possibly damaging Het
Ntpcr C T 8: 126,474,501 (GRCm39) T153M probably damaging Het
Or13p10 T A 4: 118,523,475 (GRCm39) F254I probably damaging Het
Pdzd2 A G 15: 12,374,804 (GRCm39) L1777P probably benign Het
Postn A G 3: 54,276,697 (GRCm39) N192S possibly damaging Het
Prkar1a A T 11: 109,551,877 (GRCm39) Y122F probably benign Het
Serpinb7 A G 1: 107,355,976 (GRCm39) probably benign Het
Setd3 A T 12: 108,126,496 (GRCm39) I121N probably damaging Het
Slamf7 T A 1: 171,466,810 (GRCm39) I132L probably benign Het
Syt4 T C 18: 31,580,227 (GRCm39) probably benign Het
Tesc G A 5: 118,194,504 (GRCm39) probably null Het
Tsc1 C A 2: 28,560,952 (GRCm39) S270* probably null Het
Zfp451 A G 1: 33,822,234 (GRCm39) S155P probably benign Het
Zfp469 A G 8: 122,996,472 (GRCm39) probably benign Het
Zfp51 C T 17: 21,683,844 (GRCm39) T153M probably benign Het
Zfp579 A G 7: 4,996,390 (GRCm39) I507T probably damaging Het
Other mutations in Wap
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0899:Wap UTSW 11 6,586,725 (GRCm39) missense probably benign 0.00
R1330:Wap UTSW 11 6,586,818 (GRCm39) missense unknown
R3783:Wap UTSW 11 6,588,550 (GRCm39) nonsense probably null
R3785:Wap UTSW 11 6,588,550 (GRCm39) nonsense probably null
R3786:Wap UTSW 11 6,588,550 (GRCm39) nonsense probably null
R3787:Wap UTSW 11 6,588,550 (GRCm39) nonsense probably null
R5022:Wap UTSW 11 6,587,339 (GRCm39) splice site probably benign
R5065:Wap UTSW 11 6,586,840 (GRCm39) missense probably damaging 0.96
R5664:Wap UTSW 11 6,588,609 (GRCm39) missense possibly damaging 0.86
R8112:Wap UTSW 11 6,586,724 (GRCm39) missense probably benign
Posted On 2013-04-17