Incidental Mutation 'IGL02250:Zfp873'
ID286344
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp873
Ensembl Gene ENSMUSG00000061371
Gene Namezinc finger protein 873
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.089) question?
Stock #IGL02250
Quality Score
Status
Chromosome10
Chromosomal Location82048123-82064745 bp(+) (GRCm38)
Type of Mutationstart codon destroyed
DNA Base Change (assembly) T to A at 82058418 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 1 (M1K)
Ref Sequence ENSEMBL: ENSMUSP00000100950 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105313] [ENSMUST00000209622] [ENSMUST00000210325]
Predicted Effect probably null
Transcript: ENSMUST00000105313
AA Change: M1K

PolyPhen 2 Score 0.447 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000100950
Gene: ENSMUSG00000061371
AA Change: M1K

DomainStartEndE-ValueType
ZnF_C2H2 68 90 1.12e2 SMART
ZnF_C2H2 96 117 4.69e0 SMART
ZnF_C2H2 123 145 2.06e1 SMART
ZnF_C2H2 151 173 5.5e-3 SMART
ZnF_C2H2 179 201 3.69e-4 SMART
ZnF_C2H2 207 229 3.89e-3 SMART
ZnF_C2H2 235 257 9.88e-5 SMART
ZnF_C2H2 263 285 5.59e-4 SMART
ZnF_C2H2 291 313 2.99e-4 SMART
ZnF_C2H2 319 341 1.95e-3 SMART
ZnF_C2H2 347 369 2.75e-3 SMART
ZnF_C2H2 375 397 7.37e-4 SMART
ZnF_C2H2 403 425 2.53e-2 SMART
ZnF_C2H2 431 453 9.08e-4 SMART
ZnF_C2H2 459 481 5.99e-4 SMART
ZnF_C2H2 487 509 1.22e-4 SMART
ZnF_C2H2 515 537 1.82e-3 SMART
ZnF_C2H2 543 565 2.53e-2 SMART
ZnF_C2H2 571 593 9.73e-4 SMART
ZnF_C2H2 599 619 3.13e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209614
Predicted Effect probably damaging
Transcript: ENSMUST00000209622
AA Change: W18R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000210325
AA Change: W18R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211338
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219748
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp7 T A 7: 28,629,710 probably benign Het
Antxr2 A C 5: 97,977,595 probably null Het
Areg T A 5: 91,141,108 I91K possibly damaging Het
Arf1 G A 11: 59,213,167 R79C probably benign Het
Bbs2 A T 8: 94,092,426 I105N probably benign Het
Ccdc158 A T 5: 92,608,478 I1090N probably damaging Het
Ccdc90b T A 7: 92,574,615 probably benign Het
Cep57 A T 9: 13,810,643 F221I probably damaging Het
Ckap5 C T 2: 91,548,901 A62V probably damaging Het
Cntn5 G A 9: 10,145,331 R125C probably damaging Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Cxxc1 T A 18: 74,219,169 D321E probably benign Het
Ddr1 G A 17: 35,683,480 A801V probably damaging Het
Dnm1l A G 16: 16,321,686 probably benign Het
Eif2d T A 1: 131,160,429 S184T probably benign Het
Emcn T A 3: 137,418,986 probably benign Het
Fry A T 5: 150,403,434 probably benign Het
Gas2 T A 7: 51,888,038 M37K probably damaging Het
Habp2 A G 19: 56,308,929 S100G probably benign Het
Kcnj5 A G 9: 32,317,756 C49R probably damaging Het
Lhx2 T A 2: 38,354,833 D236E probably benign Het
Megf8 T A 7: 25,342,575 S1273T probably benign Het
Mrps2 T C 2: 28,469,545 I138T possibly damaging Het
Mta1 T C 12: 113,126,798 S175P possibly damaging Het
Npat T A 9: 53,548,951 Y66* probably null Het
Nup160 A G 2: 90,708,870 R798G probably damaging Het
Olfr668 T C 7: 104,925,015 I250V probably damaging Het
Olfr921 C A 9: 38,775,554 Q100K probably damaging Het
Plxnc1 C T 10: 94,871,031 G548E probably benign Het
Radil A G 5: 142,543,774 S56P probably damaging Het
Rpgrip1l A T 8: 91,232,861 M1137K probably benign Het
Serpina1c T G 12: 103,897,228 M238L probably benign Het
Tbc1d14 A G 5: 36,571,519 S168P probably damaging Het
Tmem209 A G 6: 30,487,388 S498P probably damaging Het
Utrn A G 10: 12,436,391 Y607H probably damaging Het
Vipr1 A G 9: 121,665,189 I279V probably benign Het
Vmn2r67 T G 7: 85,155,800 N35H probably benign Het
Xirp2 C T 2: 67,514,012 T2199I probably benign Het
Zfp423 A G 8: 87,783,255 S86P probably damaging Het
Zfp831 A G 2: 174,648,201 K1254E possibly damaging Het
Other mutations in Zfp873
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0666:Zfp873 UTSW 10 82060761 missense possibly damaging 0.75
R1568:Zfp873 UTSW 10 82060279 missense probably damaging 1.00
R1739:Zfp873 UTSW 10 82060707 missense probably damaging 1.00
R1848:Zfp873 UTSW 10 82060572 missense probably benign 0.33
R1892:Zfp873 UTSW 10 82061246 missense probably damaging 1.00
R2061:Zfp873 UTSW 10 82060157 missense probably benign 0.01
R3735:Zfp873 UTSW 10 82061181 missense probably benign 0.15
R4422:Zfp873 UTSW 10 82060874 missense probably benign 0.13
R4674:Zfp873 UTSW 10 82059980 missense possibly damaging 0.53
R4839:Zfp873 UTSW 10 82060519 missense probably damaging 0.98
R5146:Zfp873 UTSW 10 82060224 missense probably damaging 1.00
R5154:Zfp873 UTSW 10 82060191 missense possibly damaging 0.54
R5160:Zfp873 UTSW 10 82061042 missense possibly damaging 0.54
R5811:Zfp873 UTSW 10 82060733 missense probably damaging 1.00
R6625:Zfp873 UTSW 10 82060304 missense probably damaging 1.00
R6667:Zfp873 UTSW 10 82060589 missense probably benign 0.22
R6742:Zfp873 UTSW 10 82058422 missense probably damaging 1.00
R6878:Zfp873 UTSW 10 82060695 missense probably benign 0.33
R7055:Zfp873 UTSW 10 82059998 missense probably damaging 1.00
R7296:Zfp873 UTSW 10 82061237 missense probably damaging 1.00
R7381:Zfp873 UTSW 10 82060971 missense probably damaging 1.00
R7448:Zfp873 UTSW 10 82060627 missense probably damaging 1.00
R7464:Zfp873 UTSW 10 82060376 missense possibly damaging 0.51
R7470:Zfp873 UTSW 10 82059939 missense probably benign 0.19
R7640:Zfp873 UTSW 10 82060275 missense possibly damaging 0.72
Posted On2015-04-16