Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02251:Vmn2r103'

286373

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL02251

Quality Score

Status

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 19793969 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 341 (N341S)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

possibly damaging
Transcript: ENSMUST00000172203
AA Change: N341S

PolyPhen 2 Score 0.837 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: N341S

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc6	A	G	7: 45,977,416 (GRCm38)	C1406R	probably damaging	Het
Acp2	T	A	2: 91,208,333 (GRCm38)		probably null	Het
Antxr2	A	C	5: 97,977,595 (GRCm38)		probably null	Het
Arhgef11	C	T	3: 87,683,547 (GRCm38)	R32C	probably damaging	Het
Armc6	A	T	8: 70,225,220 (GRCm38)	L153*	probably null	Het
Btnl2	G	T	17: 34,363,239 (GRCm38)	G260*	probably null	Het
Ccnf	A	G	17: 24,226,539 (GRCm38)	S551P	probably benign	Het
Cdh19	A	G	1: 110,954,652 (GRCm38)	S37P	probably benign	Het
Cntnap3	T	A	13: 64,762,036 (GRCm38)	T752S	probably damaging	Het
Crispld1	A	G	1: 17,728,840 (GRCm38)	M62V	probably benign	Het
Ddr1	G	A	17: 35,683,480 (GRCm38)	A801V	probably damaging	Het
Dner	G	T	1: 84,384,026 (GRCm38)	Q621K	probably damaging	Het
Dph6	A	G	2: 114,535,523 (GRCm38)		probably null	Het
Dpp3	T	G	19: 4,918,315 (GRCm38)	H243P	probably benign	Het
Eif3j2	T	A	18: 43,477,366 (GRCm38)	K127N	probably damaging	Het
Esrp1	G	A	4: 11,361,202 (GRCm38)	R315C	probably damaging	Het
Fam35a	T	C	14: 34,268,278 (GRCm38)	R224G	probably benign	Het
Gm973	A	C	1: 59,582,423 (GRCm38)	H574P	probably benign	Het
Gprasp1	G	A	X: 135,800,539 (GRCm38)	V494I	probably benign	Het
Hbb-bh1	T	A	7: 103,842,810 (GRCm38)	K66*	probably null	Het
Hoxb9	T	A	11: 96,274,825 (GRCm38)	M240K	probably damaging	Het
Irf2	T	C	8: 46,807,753 (GRCm38)		probably null	Het
Lgi4	A	G	7: 31,067,263 (GRCm38)		probably null	Het
Mylk3	C	T	8: 85,355,176 (GRCm38)	V328M	probably benign	Het
Nf2	T	C	11: 4,848,873 (GRCm38)	E38G	probably null	Het
Olfr1286	A	C	2: 111,420,312 (GRCm38)	L213R	probably damaging	Het
Olfr606	A	T	7: 103,451,771 (GRCm38)	K145*	probably null	Het
Pdpk1	A	G	17: 24,079,638 (GRCm38)	F346L	probably damaging	Het
Prex1	T	C	2: 166,577,886 (GRCm38)	Y1120C	probably damaging	Het
Rab3gap1	A	G	1: 127,937,500 (GRCm38)	T742A	probably benign	Het
Scai	A	T	2: 39,099,417 (GRCm38)	D401E	probably benign	Het
Scd1	T	C	19: 44,398,094 (GRCm38)	H298R	probably damaging	Het
Slc45a1	A	G	4: 150,638,719 (GRCm38)		probably benign	Het
Smim10l1	G	T	6: 133,105,508 (GRCm38)	R6L	probably damaging	Het
Spag5	T	G	11: 78,320,034 (GRCm38)	F921C	probably damaging	Het
Sun1	T	C	5: 139,241,431 (GRCm38)	S667P	probably damaging	Het
Tas2r124	A	G	6: 132,755,561 (GRCm38)	I278V	probably benign	Het
Thbs1	G	A	2: 118,113,518 (GRCm38)	D206N	probably benign	Het
Trim37	T	A	11: 87,167,430 (GRCm38)		probably benign	Het
Vcp	T	C	4: 42,988,728 (GRCm38)	T249A	possibly damaging	Het
Zmat3	A	G	3: 32,345,583 (GRCm38)		probably benign	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19,793,102 (GRCm38)	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19,794,965 (GRCm38)	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	19,792,997 (GRCm38)	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	19,792,967 (GRCm38)	missense	probably benign
IGL01404:Vmn2r103	APN	17	19,812,434 (GRCm38)	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19,794,068 (GRCm38)	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19,799,208 (GRCm38)	missense	probably benign
IGL02466:Vmn2r103	APN	17	19,773,369 (GRCm38)	missense	probably benign
IGL02555:Vmn2r103	APN	17	19,811,611 (GRCm38)	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	19,794,127 (GRCm38)	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	19,793,956 (GRCm38)	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19,812,248 (GRCm38)	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19,773,520 (GRCm38)	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19,811,979 (GRCm38)	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19,811,641 (GRCm38)	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19,793,464 (GRCm38)	missense	probably benign	0.12
R0375:Vmn2r103	UTSW	17	19,792,859 (GRCm38)	missense	probably benign	0.06
R0755:Vmn2r103	UTSW	17	19,773,568 (GRCm38)	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	19,793,927 (GRCm38)	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	19,794,247 (GRCm38)	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19,792,968 (GRCm38)	missense	probably benign
R1488:Vmn2r103	UTSW	17	19,793,660 (GRCm38)	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19,773,400 (GRCm38)	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	19,794,234 (GRCm38)	missense	probably benign
R1928:Vmn2r103	UTSW	17	19,811,767 (GRCm38)	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19,812,300 (GRCm38)	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19,793,794 (GRCm38)	missense	probably benign
R2219:Vmn2r103	UTSW	17	19,793,647 (GRCm38)	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19,773,531 (GRCm38)	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19,793,600 (GRCm38)	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19,812,149 (GRCm38)	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	19,793,604 (GRCm38)	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	19,794,233 (GRCm38)	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19,793,696 (GRCm38)	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19,793,696 (GRCm38)	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19,793,696 (GRCm38)	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	19,811,815 (GRCm38)	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	19,795,076 (GRCm38)	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19,795,076 (GRCm38)	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19,811,769 (GRCm38)	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19,773,511 (GRCm38)	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19,793,034 (GRCm38)	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19,793,034 (GRCm38)	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19,812,171 (GRCm38)	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19,793,642 (GRCm38)	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	19,792,989 (GRCm38)	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	19,794,939 (GRCm38)	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19,812,453 (GRCm38)	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19,794,216 (GRCm38)	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19,812,325 (GRCm38)	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19,812,144 (GRCm38)	missense	probably benign
R6292:Vmn2r103	UTSW	17	19,793,604 (GRCm38)	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19,794,082 (GRCm38)	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	19,811,904 (GRCm38)	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	19,811,977 (GRCm38)	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19,773,511 (GRCm38)	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	19,793,477 (GRCm38)	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	19,812,052 (GRCm38)	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	19,794,214 (GRCm38)	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	19,793,123 (GRCm38)	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	19,799,249 (GRCm38)	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	19,793,497 (GRCm38)	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	19,811,796 (GRCm38)	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	19,811,943 (GRCm38)	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	19,812,384 (GRCm38)	missense	probably benign	0.01
R9413:Vmn2r103	UTSW	17	19,811,896 (GRCm38)	missense	possibly damaging	0.54
R9591:Vmn2r103	UTSW	17	19,811,659 (GRCm38)	missense	possibly damaging	0.70
R9652:Vmn2r103	UTSW	17	19,793,765 (GRCm38)	missense	probably benign	0.01
R9680:Vmn2r103	UTSW	17	19,799,263 (GRCm38)	nonsense	probably null
R9743:Vmn2r103	UTSW	17	19,812,213 (GRCm38)	missense	probably damaging	1.00
Z1088:Vmn2r103	UTSW	17	19,795,047 (GRCm38)	missense	probably benign	0.08

Posted On

2015-04-16