Incidental Mutation 'IGL02251:Olfr606'
ID286377
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr606
Ensembl Gene ENSMUSG00000073949
Gene Nameolfactory receptor 606
SynonymsMOR17-2, GA_x6K02T2PBJ9-6173009-6173968
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.091) question?
Stock #IGL02251
Quality Score
Status
Chromosome7
Chromosomal Location103449046-103453531 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 103451771 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Stop codon at position 145 (K145*)
Ref Sequence ENSEMBL: ENSMUSP00000151177 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098200] [ENSMUST00000214347] [ENSMUST00000214631] [ENSMUST00000217250]
Predicted Effect probably null
Transcript: ENSMUST00000098200
AA Change: K145*
SMART Domains Protein: ENSMUSP00000095802
Gene: ENSMUSG00000073949
AA Change: K145*

DomainStartEndE-ValueType
low complexity region 4 12 N/A INTRINSIC
Pfam:7tm_4 33 312 7.1e-116 PFAM
Pfam:7TM_GPCR_Srsx 37 307 9e-8 PFAM
Pfam:7tm_1 43 294 7.4e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214347
Predicted Effect probably null
Transcript: ENSMUST00000214631
AA Change: K145*
Predicted Effect probably null
Transcript: ENSMUST00000217250
AA Change: K145*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 A G 7: 45,977,416 C1406R probably damaging Het
Acp2 T A 2: 91,208,333 probably null Het
Antxr2 A C 5: 97,977,595 probably null Het
Arhgef11 C T 3: 87,683,547 R32C probably damaging Het
Armc6 A T 8: 70,225,220 L153* probably null Het
Btnl2 G T 17: 34,363,239 G260* probably null Het
Ccnf A G 17: 24,226,539 S551P probably benign Het
Cdh19 A G 1: 110,954,652 S37P probably benign Het
Cntnap3 T A 13: 64,762,036 T752S probably damaging Het
Crispld1 A G 1: 17,728,840 M62V probably benign Het
Ddr1 G A 17: 35,683,480 A801V probably damaging Het
Dner G T 1: 84,384,026 Q621K probably damaging Het
Dph6 A G 2: 114,535,523 probably null Het
Dpp3 T G 19: 4,918,315 H243P probably benign Het
Eif3j2 T A 18: 43,477,366 K127N probably damaging Het
Esrp1 G A 4: 11,361,202 R315C probably damaging Het
Fam35a T C 14: 34,268,278 R224G probably benign Het
Gm973 A C 1: 59,582,423 H574P probably benign Het
Gprasp1 G A X: 135,800,539 V494I probably benign Het
Hbb-bh1 T A 7: 103,842,810 K66* probably null Het
Hoxb9 T A 11: 96,274,825 M240K probably damaging Het
Irf2 T C 8: 46,807,753 probably null Het
Lgi4 A G 7: 31,067,263 probably null Het
Mylk3 C T 8: 85,355,176 V328M probably benign Het
Nf2 T C 11: 4,848,873 E38G probably null Het
Olfr1286 A C 2: 111,420,312 L213R probably damaging Het
Pdpk1 A G 17: 24,079,638 F346L probably damaging Het
Prex1 T C 2: 166,577,886 Y1120C probably damaging Het
Rab3gap1 A G 1: 127,937,500 T742A probably benign Het
Scai A T 2: 39,099,417 D401E probably benign Het
Scd1 T C 19: 44,398,094 H298R probably damaging Het
Slc45a1 A G 4: 150,638,719 probably benign Het
Smim10l1 G T 6: 133,105,508 R6L probably damaging Het
Spag5 T G 11: 78,320,034 F921C probably damaging Het
Sun1 T C 5: 139,241,431 S667P probably damaging Het
Tas2r124 A G 6: 132,755,561 I278V probably benign Het
Thbs1 G A 2: 118,113,518 D206N probably benign Het
Trim37 T A 11: 87,167,430 probably benign Het
Vcp T C 4: 42,988,728 T249A possibly damaging Het
Vmn2r103 A G 17: 19,793,969 N341S possibly damaging Het
Zmat3 A G 3: 32,345,583 probably benign Het
Other mutations in Olfr606
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01287:Olfr606 APN 7 103451795 missense probably damaging 1.00
IGL01608:Olfr606 APN 7 103451804 missense probably benign 0.00
IGL02319:Olfr606 APN 7 103452267 missense probably benign 0.01
R0369:Olfr606 UTSW 7 103452216 missense probably damaging 1.00
R0480:Olfr606 UTSW 7 103451628 missense probably benign 0.07
R1759:Olfr606 UTSW 7 103452149 missense probably benign 0.11
R1858:Olfr606 UTSW 7 103452125 missense probably benign 0.16
R2156:Olfr606 UTSW 7 103452164 missense probably benign 0.01
R4226:Olfr606 UTSW 7 103451577 missense probably benign 0.31
R4422:Olfr606 UTSW 7 103452243 missense probably damaging 0.99
R5071:Olfr606 UTSW 7 103451410 missense probably benign
R5074:Olfr606 UTSW 7 103451410 missense probably benign
R5137:Olfr606 UTSW 7 103451712 missense probably damaging 1.00
R5137:Olfr606 UTSW 7 103451713 nonsense probably null
X0018:Olfr606 UTSW 7 103451798 missense possibly damaging 0.72
Posted On2015-04-16