Incidental Mutation 'IGL02252:Zfp352'
ID 286425
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp352
Ensembl Gene ENSMUSG00000070902
Gene Name zinc finger protein 352
Synonyms 2czf48
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02252
Quality Score
Status
Chromosome 4
Chromosomal Location 90107057-90113924 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 90112367 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 169 (D169V)
Ref Sequence ENSEMBL: ENSMUSP00000102746 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080541] [ENSMUST00000107129]
AlphaFold A2AML7
Predicted Effect probably benign
Transcript: ENSMUST00000080541
AA Change: D169V

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000079383
Gene: ENSMUSG00000070902
AA Change: D169V

DomainStartEndE-ValueType
ZnF_C2H2 459 483 3.34e-2 SMART
ZnF_C2H2 489 513 8.22e-2 SMART
ZnF_C2H2 519 542 1.76e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000107129
AA Change: D169V

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000102746
Gene: ENSMUSG00000070902
AA Change: D169V

DomainStartEndE-ValueType
ZnF_C2H2 459 483 3.34e-2 SMART
ZnF_C2H2 489 513 8.22e-2 SMART
ZnF_C2H2 519 542 1.76e-1 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933409G03Rik A G 2: 68,444,678 (GRCm39) probably benign Het
Actl7b A T 4: 56,741,205 (GRCm39) I51N probably damaging Het
Adamts12 A G 15: 11,311,101 (GRCm39) I1119M probably benign Het
Apol10a T A 15: 77,372,670 (GRCm39) V102D probably benign Het
Atrx T C X: 104,889,429 (GRCm39) E1628G possibly damaging Het
Btnl2 C T 17: 34,584,364 (GRCm39) S429F possibly damaging Het
C4bp C A 1: 130,564,524 (GRCm39) D387Y probably damaging Het
Ceacam23 G T 7: 17,644,457 (GRCm39) V525F possibly damaging Het
Crybg3 G T 16: 59,372,887 (GRCm39) probably benign Het
Dcaf12 G T 4: 41,294,085 (GRCm39) H351N probably benign Het
Efcab3 C A 11: 104,644,753 (GRCm39) R1114S possibly damaging Het
Elp1 G T 4: 56,759,813 (GRCm39) Q1151K probably benign Het
Fign A G 2: 63,810,983 (GRCm39) S96P probably benign Het
Ggt5 A G 10: 75,438,566 (GRCm39) I96V possibly damaging Het
Gm3238 A G 10: 77,606,691 (GRCm39) probably benign Het
Gm4792 G T 10: 94,131,102 (GRCm39) P69Q unknown Het
Ighv1-58 A T 12: 115,275,897 (GRCm39) N80K possibly damaging Het
Irgm1 C T 11: 48,756,981 (GRCm39) G277S possibly damaging Het
Jsrp1 A G 10: 80,644,707 (GRCm39) V233A probably benign Het
Kcp T A 6: 29,504,548 (GRCm39) R85W probably damaging Het
Kif14 T C 1: 136,406,130 (GRCm39) Y565H probably damaging Het
Klk1b4 G A 7: 43,860,094 (GRCm39) W69* probably null Het
Knl1 A T 2: 118,903,021 (GRCm39) Q1574L probably damaging Het
Lao1 A G 4: 118,824,613 (GRCm39) N232D probably benign Het
Lipn A G 19: 34,049,157 (GRCm39) I108V probably benign Het
Lrrc49 T A 9: 60,595,142 (GRCm39) M1L probably benign Het
Matn2 G T 15: 34,316,736 (GRCm39) R26L probably damaging Het
Mmp16 G A 4: 18,110,523 (GRCm39) D440N probably damaging Het
Mn1 G A 5: 111,569,107 (GRCm39) A1026T probably damaging Het
Mrgpra1 A T 7: 46,984,912 (GRCm39) F256I probably benign Het
Msantd3 A C 4: 48,560,869 (GRCm39) E148D probably benign Het
Mylk3 G T 8: 86,082,105 (GRCm39) L361I probably benign Het
Nlrp12 A G 7: 3,293,980 (GRCm39) S117P probably benign Het
Nsmaf T C 4: 6,398,378 (GRCm39) E870G probably benign Het
Oplah T C 15: 76,188,964 (GRCm39) T320A probably damaging Het
Or5p50 C A 7: 107,422,353 (GRCm39) A108S probably benign Het
Or7g34 T A 9: 19,478,267 (GRCm39) I138F probably damaging Het
Pard3 T G 8: 128,125,237 (GRCm39) S729A probably benign Het
Pdzd9 T C 7: 120,262,238 (GRCm39) I75V probably benign Het
Pgf A G 12: 85,216,199 (GRCm39) probably benign Het
Phf1 T A 17: 27,154,109 (GRCm39) V140D possibly damaging Het
Pkd1l3 T C 8: 110,357,708 (GRCm39) S775P possibly damaging Het
Rhobtb1 A T 10: 69,085,515 (GRCm39) T85S probably damaging Het
Sez6 T A 11: 77,865,339 (GRCm39) Y659N probably damaging Het
Sfmbt1 T C 14: 30,539,690 (GRCm39) L826P probably damaging Het
Sftpd T A 14: 40,894,471 (GRCm39) D316V probably damaging Het
Shc2 T C 10: 79,462,204 (GRCm39) D313G probably benign Het
Snrk T C 9: 121,986,326 (GRCm39) Y232H probably damaging Het
Sntg1 G T 1: 8,484,452 (GRCm39) P456Q probably benign Het
Sorbs1 A T 19: 40,302,841 (GRCm39) N783K probably damaging Het
Stag3 A T 5: 138,300,810 (GRCm39) I923F probably damaging Het
Tep1 T A 14: 51,067,712 (GRCm39) H2168L possibly damaging Het
Tmem132c A T 5: 127,539,991 (GRCm39) N339I possibly damaging Het
Trim34b A G 7: 103,979,139 (GRCm39) T129A probably damaging Het
Ttc21a T C 9: 119,785,994 (GRCm39) L664P probably damaging Het
Ubl5 C T 9: 20,556,923 (GRCm39) R56* probably null Het
Ubox5 G A 2: 130,441,707 (GRCm39) R327W probably damaging Het
Ubr5 G T 15: 38,025,138 (GRCm39) A546E probably damaging Het
Umodl1 T C 17: 31,213,789 (GRCm39) probably null Het
Unc45a T C 7: 79,982,717 (GRCm39) probably benign Het
Vmn1r236 C T 17: 21,507,101 (GRCm39) T73I probably benign Het
Vmn2r67 T G 7: 84,805,008 (GRCm39) N35H probably benign Het
Vmn2r74 A G 7: 85,606,531 (GRCm39) Y272H probably benign Het
Wdr43 T A 17: 71,933,845 (GRCm39) D147E probably damaging Het
Zim1 A T 7: 6,691,627 (GRCm39) N15K unknown Het
Other mutations in Zfp352
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01963:Zfp352 APN 4 90,112,391 (GRCm39) missense possibly damaging 0.95
IGL03156:Zfp352 APN 4 90,112,324 (GRCm39) missense possibly damaging 0.57
IGL03167:Zfp352 APN 4 90,112,939 (GRCm39) missense probably damaging 0.99
IGL03190:Zfp352 APN 4 90,111,994 (GRCm39) missense possibly damaging 0.94
IGL03335:Zfp352 APN 4 90,112,583 (GRCm39) missense probably damaging 0.99
R0051:Zfp352 UTSW 4 90,112,522 (GRCm39) missense probably damaging 0.99
R0403:Zfp352 UTSW 4 90,113,246 (GRCm39) missense possibly damaging 0.60
R0550:Zfp352 UTSW 4 90,112,927 (GRCm39) missense probably damaging 0.99
R0671:Zfp352 UTSW 4 90,112,156 (GRCm39) missense probably benign
R1034:Zfp352 UTSW 4 90,112,393 (GRCm39) missense possibly damaging 0.94
R1754:Zfp352 UTSW 4 90,112,046 (GRCm39) missense probably benign 0.23
R2016:Zfp352 UTSW 4 90,113,408 (GRCm39) missense probably benign 0.42
R2064:Zfp352 UTSW 4 90,113,357 (GRCm39) missense probably benign 0.08
R2308:Zfp352 UTSW 4 90,113,480 (GRCm39) missense probably benign 0.00
R3552:Zfp352 UTSW 4 90,113,339 (GRCm39) missense probably benign 0.33
R3794:Zfp352 UTSW 4 90,113,386 (GRCm39) missense probably damaging 1.00
R3795:Zfp352 UTSW 4 90,113,386 (GRCm39) missense probably damaging 1.00
R4135:Zfp352 UTSW 4 90,113,261 (GRCm39) missense probably damaging 0.96
R4356:Zfp352 UTSW 4 90,112,071 (GRCm39) missense possibly damaging 0.91
R4409:Zfp352 UTSW 4 90,113,401 (GRCm39) missense probably benign 0.00
R4590:Zfp352 UTSW 4 90,112,772 (GRCm39) missense probably damaging 0.98
R4614:Zfp352 UTSW 4 90,113,318 (GRCm39) missense probably benign 0.00
R4617:Zfp352 UTSW 4 90,113,318 (GRCm39) missense probably benign 0.00
R4618:Zfp352 UTSW 4 90,113,318 (GRCm39) missense probably benign 0.00
R4741:Zfp352 UTSW 4 90,113,177 (GRCm39) missense possibly damaging 0.94
R4931:Zfp352 UTSW 4 90,112,541 (GRCm39) missense probably damaging 0.98
R4959:Zfp352 UTSW 4 90,112,376 (GRCm39) missense probably benign 0.01
R4973:Zfp352 UTSW 4 90,112,376 (GRCm39) missense probably benign 0.01
R5167:Zfp352 UTSW 4 90,112,453 (GRCm39) missense possibly damaging 0.94
R5260:Zfp352 UTSW 4 90,112,697 (GRCm39) missense probably damaging 0.99
R5524:Zfp352 UTSW 4 90,113,341 (GRCm39) missense possibly damaging 0.95
R5942:Zfp352 UTSW 4 90,113,307 (GRCm39) missense probably damaging 0.98
R6802:Zfp352 UTSW 4 90,113,437 (GRCm39) missense probably benign 0.33
R6819:Zfp352 UTSW 4 90,112,936 (GRCm39) missense probably benign
R7072:Zfp352 UTSW 4 90,112,661 (GRCm39) missense probably benign 0.00
R7099:Zfp352 UTSW 4 90,113,117 (GRCm39) missense probably benign 0.00
R7569:Zfp352 UTSW 4 90,111,896 (GRCm39) missense possibly damaging 0.77
R7645:Zfp352 UTSW 4 90,113,014 (GRCm39) missense probably benign 0.13
R7705:Zfp352 UTSW 4 90,113,512 (GRCm39) missense possibly damaging 0.94
R8424:Zfp352 UTSW 4 90,112,480 (GRCm39) missense possibly damaging 0.87
R9180:Zfp352 UTSW 4 90,113,118 (GRCm39) missense probably benign 0.38
R9378:Zfp352 UTSW 4 90,112,575 (GRCm39) missense probably benign 0.13
R9509:Zfp352 UTSW 4 90,112,943 (GRCm39) missense probably damaging 0.99
R9623:Zfp352 UTSW 4 90,113,128 (GRCm39) missense probably benign 0.00
Posted On 2015-04-16