Incidental Mutation 'IGL02252:Pgf'
ID 286473
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pgf
Ensembl Gene ENSMUSG00000004791
Gene Name placental growth factor
Synonyms placenta growth factor, PLGF, PIGF
Accession Numbers
Essential gene? Possibly essential (E-score: 0.554) question?
Stock # IGL02252
Quality Score
Status
Chromosome 12
Chromosomal Location 85213411-85224559 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 85216199 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000152165 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004913] [ENSMUST00000223220]
AlphaFold P49764
Predicted Effect probably benign
Transcript: ENSMUST00000004913
SMART Domains Protein: ENSMUSP00000004913
Gene: ENSMUSG00000004791

DomainStartEndE-ValueType
PDGF 46 129 2.96e-49 SMART
low complexity region 133 149 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220985
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222850
Predicted Effect probably benign
Transcript: ENSMUST00000223220
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
PHENOTYPE: Mice homozygous for disruptions in this gene display subtle abnormalities related to reduced angiogenesis. Body weight at birth is reduced and body fat is significantly reduced. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933409G03Rik A G 2: 68,444,678 (GRCm39) probably benign Het
Actl7b A T 4: 56,741,205 (GRCm39) I51N probably damaging Het
Adamts12 A G 15: 11,311,101 (GRCm39) I1119M probably benign Het
Apol10a T A 15: 77,372,670 (GRCm39) V102D probably benign Het
Atrx T C X: 104,889,429 (GRCm39) E1628G possibly damaging Het
Btnl2 C T 17: 34,584,364 (GRCm39) S429F possibly damaging Het
C4bp C A 1: 130,564,524 (GRCm39) D387Y probably damaging Het
Ceacam23 G T 7: 17,644,457 (GRCm39) V525F possibly damaging Het
Crybg3 G T 16: 59,372,887 (GRCm39) probably benign Het
Dcaf12 G T 4: 41,294,085 (GRCm39) H351N probably benign Het
Efcab3 C A 11: 104,644,753 (GRCm39) R1114S possibly damaging Het
Elp1 G T 4: 56,759,813 (GRCm39) Q1151K probably benign Het
Fign A G 2: 63,810,983 (GRCm39) S96P probably benign Het
Ggt5 A G 10: 75,438,566 (GRCm39) I96V possibly damaging Het
Gm3238 A G 10: 77,606,691 (GRCm39) probably benign Het
Gm4792 G T 10: 94,131,102 (GRCm39) P69Q unknown Het
Ighv1-58 A T 12: 115,275,897 (GRCm39) N80K possibly damaging Het
Irgm1 C T 11: 48,756,981 (GRCm39) G277S possibly damaging Het
Jsrp1 A G 10: 80,644,707 (GRCm39) V233A probably benign Het
Kcp T A 6: 29,504,548 (GRCm39) R85W probably damaging Het
Kif14 T C 1: 136,406,130 (GRCm39) Y565H probably damaging Het
Klk1b4 G A 7: 43,860,094 (GRCm39) W69* probably null Het
Knl1 A T 2: 118,903,021 (GRCm39) Q1574L probably damaging Het
Lao1 A G 4: 118,824,613 (GRCm39) N232D probably benign Het
Lipn A G 19: 34,049,157 (GRCm39) I108V probably benign Het
Lrrc49 T A 9: 60,595,142 (GRCm39) M1L probably benign Het
Matn2 G T 15: 34,316,736 (GRCm39) R26L probably damaging Het
Mmp16 G A 4: 18,110,523 (GRCm39) D440N probably damaging Het
Mn1 G A 5: 111,569,107 (GRCm39) A1026T probably damaging Het
Mrgpra1 A T 7: 46,984,912 (GRCm39) F256I probably benign Het
Msantd3 A C 4: 48,560,869 (GRCm39) E148D probably benign Het
Mylk3 G T 8: 86,082,105 (GRCm39) L361I probably benign Het
Nlrp12 A G 7: 3,293,980 (GRCm39) S117P probably benign Het
Nsmaf T C 4: 6,398,378 (GRCm39) E870G probably benign Het
Oplah T C 15: 76,188,964 (GRCm39) T320A probably damaging Het
Or5p50 C A 7: 107,422,353 (GRCm39) A108S probably benign Het
Or7g34 T A 9: 19,478,267 (GRCm39) I138F probably damaging Het
Pard3 T G 8: 128,125,237 (GRCm39) S729A probably benign Het
Pdzd9 T C 7: 120,262,238 (GRCm39) I75V probably benign Het
Phf1 T A 17: 27,154,109 (GRCm39) V140D possibly damaging Het
Pkd1l3 T C 8: 110,357,708 (GRCm39) S775P possibly damaging Het
Rhobtb1 A T 10: 69,085,515 (GRCm39) T85S probably damaging Het
Sez6 T A 11: 77,865,339 (GRCm39) Y659N probably damaging Het
Sfmbt1 T C 14: 30,539,690 (GRCm39) L826P probably damaging Het
Sftpd T A 14: 40,894,471 (GRCm39) D316V probably damaging Het
Shc2 T C 10: 79,462,204 (GRCm39) D313G probably benign Het
Snrk T C 9: 121,986,326 (GRCm39) Y232H probably damaging Het
Sntg1 G T 1: 8,484,452 (GRCm39) P456Q probably benign Het
Sorbs1 A T 19: 40,302,841 (GRCm39) N783K probably damaging Het
Stag3 A T 5: 138,300,810 (GRCm39) I923F probably damaging Het
Tep1 T A 14: 51,067,712 (GRCm39) H2168L possibly damaging Het
Tmem132c A T 5: 127,539,991 (GRCm39) N339I possibly damaging Het
Trim34b A G 7: 103,979,139 (GRCm39) T129A probably damaging Het
Ttc21a T C 9: 119,785,994 (GRCm39) L664P probably damaging Het
Ubl5 C T 9: 20,556,923 (GRCm39) R56* probably null Het
Ubox5 G A 2: 130,441,707 (GRCm39) R327W probably damaging Het
Ubr5 G T 15: 38,025,138 (GRCm39) A546E probably damaging Het
Umodl1 T C 17: 31,213,789 (GRCm39) probably null Het
Unc45a T C 7: 79,982,717 (GRCm39) probably benign Het
Vmn1r236 C T 17: 21,507,101 (GRCm39) T73I probably benign Het
Vmn2r67 T G 7: 84,805,008 (GRCm39) N35H probably benign Het
Vmn2r74 A G 7: 85,606,531 (GRCm39) Y272H probably benign Het
Wdr43 T A 17: 71,933,845 (GRCm39) D147E probably damaging Het
Zfp352 A T 4: 90,112,367 (GRCm39) D169V probably benign Het
Zim1 A T 7: 6,691,627 (GRCm39) N15K unknown Het
Other mutations in Pgf
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01151:Pgf APN 12 85,218,510 (GRCm39) missense probably damaging 1.00
R0324:Pgf UTSW 12 85,218,198 (GRCm39) missense probably benign 0.29
R0658:Pgf UTSW 12 85,216,159 (GRCm39) missense probably benign
R1168:Pgf UTSW 12 85,218,541 (GRCm39) missense probably benign 0.02
R1778:Pgf UTSW 12 85,218,541 (GRCm39) missense probably benign 0.02
R4191:Pgf UTSW 12 85,218,561 (GRCm39) missense probably benign 0.03
R4820:Pgf UTSW 12 85,218,538 (GRCm39) missense probably benign 0.04
R5777:Pgf UTSW 12 85,216,148 (GRCm39) missense possibly damaging 0.54
R7211:Pgf UTSW 12 85,222,549 (GRCm39) missense probably benign 0.41
RF012:Pgf UTSW 12 85,216,316 (GRCm39) critical splice acceptor site probably null
Posted On 2015-04-16