Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02255:Vmn2r81'

286559

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r81

Ensembl Gene

ENSMUSG00000055515

Gene Name

vomeronasal 2, receptor 81

Synonyms

pheromone recepter, V2rf2, EC1-VR2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

IGL02255

Quality Score

Status

Chromosome

Chromosomal Location

79083611-79130369 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 79083806 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Stop codon at position 60 (W60*)

Ref Sequence

ENSEMBL: ENSMUSP00000020547 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020547]

AlphaFold

Q80Z09

Predicted Effect

probably null
Transcript: ENSMUST00000020547
AA Change: W60*

SMART Domains

Protein: ENSMUSP00000020547
Gene: ENSMUSG00000055515
AA Change: W60*

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	79	474	7.7e-37	PFAM
Pfam:NCD3G	517	570	8.9e-21	PFAM
Pfam:7tm_3	603	838	6.1e-50	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit vomeronasal sensory neuron axons that spread out diffusely over the posterior accessory olfactory bulb and extend abnormally into the anterior olfactory bulb. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 22 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acot4	C	T	12: 84,088,799 (GRCm39)	L216F	probably damaging	Het
Acp7	C	T	7: 28,314,148 (GRCm39)	C349Y	probably damaging	Het
Cdc42ep5	G	A	7: 4,154,399 (GRCm39)	Q130*	probably null	Het
Cip2a	T	A	16: 48,831,176 (GRCm39)	D541E	probably damaging	Het
Dmxl2	A	G	9: 54,301,052 (GRCm39)	I2353T	probably benign	Het
Dnmt3a	T	A	12: 3,922,886 (GRCm39)		probably benign	Het
Dtx3l	A	G	16: 35,753,706 (GRCm39)	V300A	probably benign	Het
Fbxo15	G	T	18: 84,982,321 (GRCm39)		probably null	Het
Fbxw22	C	A	9: 109,215,619 (GRCm39)		probably benign	Het
Gli2	A	T	1: 118,772,079 (GRCm39)		probably null	Het
Gli3	T	A	13: 15,823,304 (GRCm39)	I342N	probably damaging	Het
Gm5431	T	A	11: 48,779,785 (GRCm39)	N657I	possibly damaging	Het
Mybpc1	A	T	10: 88,372,290 (GRCm39)	I766N	probably damaging	Het
Or5b119	T	A	19: 13,457,349 (GRCm39)	Y71F	probably damaging	Het
Pkhd1	A	T	1: 20,654,325 (GRCm39)	I244N	probably damaging	Het
Ret	G	T	6: 118,152,081 (GRCm39)		probably null	Het
Rrp12	A	T	19: 41,861,410 (GRCm39)	F966I	probably damaging	Het
Rubcn	T	C	16: 32,647,715 (GRCm39)	I681V	probably benign	Het
Selenof	T	C	3: 144,302,588 (GRCm39)	V121A	possibly damaging	Het
Srl	A	T	16: 4,305,422 (GRCm39)	V541D	probably damaging	Het
Thbs2	T	C	17: 14,910,047 (GRCm39)	E184G	probably benign	Het
Zfp526	A	G	7: 24,924,958 (GRCm39)	M406V	possibly damaging	Het

Other mutations in Vmn2r81

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01111:Vmn2r81	APN	10	79,083,831 (GRCm39)	missense	probably benign	0.20
IGL02901:Vmn2r81	APN	10	79,106,564 (GRCm39)	missense	probably damaging	0.98
R0383:Vmn2r81	UTSW	10	79,129,281 (GRCm39)	missense	possibly damaging	0.95
R0555:Vmn2r81	UTSW	10	79,129,283 (GRCm39)	missense	probably damaging	1.00
R0715:Vmn2r81	UTSW	10	79,104,434 (GRCm39)	missense	probably damaging	1.00
R0967:Vmn2r81	UTSW	10	79,083,857 (GRCm39)	splice site	probably benign
R1438:Vmn2r81	UTSW	10	79,129,691 (GRCm39)	missense	probably benign	0.00
R1468:Vmn2r81	UTSW	10	79,129,496 (GRCm39)	missense	probably damaging	1.00
R1468:Vmn2r81	UTSW	10	79,129,496 (GRCm39)	missense	probably damaging	1.00
R1589:Vmn2r81	UTSW	10	79,128,858 (GRCm39)	missense	probably damaging	0.99
R1671:Vmn2r81	UTSW	10	79,103,265 (GRCm39)	missense	probably benign	0.04
R1672:Vmn2r81	UTSW	10	79,104,112 (GRCm39)	missense	probably damaging	0.99
R1728:Vmn2r81	UTSW	10	79,106,489 (GRCm39)	missense	probably benign	0.08
R1784:Vmn2r81	UTSW	10	79,106,489 (GRCm39)	missense	probably benign	0.08
R1931:Vmn2r81	UTSW	10	79,129,328 (GRCm39)	missense	probably damaging	0.98
R1934:Vmn2r81	UTSW	10	79,083,628 (GRCm39)	start codon destroyed	probably null	0.71
R1944:Vmn2r81	UTSW	10	79,129,571 (GRCm39)	missense	probably damaging	1.00
R2102:Vmn2r81	UTSW	10	79,129,334 (GRCm39)	missense	probably damaging	0.97
R2190:Vmn2r81	UTSW	10	79,104,085 (GRCm39)	missense	possibly damaging	0.67
R2392:Vmn2r81	UTSW	10	79,110,516 (GRCm39)	missense	probably damaging	1.00
R3770:Vmn2r81	UTSW	10	79,106,434 (GRCm39)	missense	probably damaging	1.00
R4551:Vmn2r81	UTSW	10	79,104,241 (GRCm39)	missense	possibly damaging	0.95
R4629:Vmn2r81	UTSW	10	79,103,276 (GRCm39)	missense	probably damaging	0.99
R4691:Vmn2r81	UTSW	10	79,129,211 (GRCm39)	nonsense	probably null
R4829:Vmn2r81	UTSW	10	79,083,635 (GRCm39)	missense	possibly damaging	0.48
R4914:Vmn2r81	UTSW	10	79,106,357 (GRCm39)	missense	probably null	1.00
R4996:Vmn2r81	UTSW	10	79,129,247 (GRCm39)	missense	probably benign	0.04
R5242:Vmn2r81	UTSW	10	79,129,309 (GRCm39)	nonsense	probably null
R5253:Vmn2r81	UTSW	10	79,083,820 (GRCm39)	missense	probably benign	0.00
R5925:Vmn2r81	UTSW	10	79,083,637 (GRCm39)	missense	probably damaging	1.00
R6169:Vmn2r81	UTSW	10	79,104,382 (GRCm39)	missense	probably benign
R6270:Vmn2r81	UTSW	10	79,129,649 (GRCm39)	missense	probably benign
R6525:Vmn2r81	UTSW	10	79,129,560 (GRCm39)	missense	probably benign	0.11
R6813:Vmn2r81	UTSW	10	79,104,439 (GRCm39)	missense	probably benign	0.00
R6886:Vmn2r81	UTSW	10	79,103,988 (GRCm39)	missense	possibly damaging	0.90
R7200:Vmn2r81	UTSW	10	79,106,570 (GRCm39)	critical splice donor site	probably null
R7350:Vmn2r81	UTSW	10	79,104,219 (GRCm39)	missense	probably benign	0.03
R7504:Vmn2r81	UTSW	10	79,104,166 (GRCm39)	missense	probably benign
R7832:Vmn2r81	UTSW	10	79,129,664 (GRCm39)	missense	probably damaging	1.00
R8130:Vmn2r81	UTSW	10	79,110,538 (GRCm39)	missense	possibly damaging	0.95
R8362:Vmn2r81	UTSW	10	79,103,283 (GRCm39)	missense	probably benign	0.17
R8407:Vmn2r81	UTSW	10	79,104,028 (GRCm39)	missense	possibly damaging	0.92
R8540:Vmn2r81	UTSW	10	79,129,065 (GRCm39)	missense	probably damaging	0.99
R8558:Vmn2r81	UTSW	10	79,106,467 (GRCm39)	missense	possibly damaging	0.94
R8700:Vmn2r81	UTSW	10	79,129,517 (GRCm39)	missense	probably damaging	1.00
R8779:Vmn2r81	UTSW	10	79,103,218 (GRCm39)	missense	possibly damaging	0.78
R8987:Vmn2r81	UTSW	10	79,129,704 (GRCm39)	missense	probably damaging	1.00
R9001:Vmn2r81	UTSW	10	79,104,104 (GRCm39)	missense	possibly damaging	0.73
R9055:Vmn2r81	UTSW	10	79,110,441 (GRCm39)	missense	probably benign
R9145:Vmn2r81	UTSW	10	79,104,028 (GRCm39)	missense	possibly damaging	0.92
R9151:Vmn2r81	UTSW	10	79,103,905 (GRCm39)	missense
R9253:Vmn2r81	UTSW	10	79,129,582 (GRCm39)	missense	probably damaging	1.00
R9255:Vmn2r81	UTSW	10	79,103,166 (GRCm39)	missense	possibly damaging	0.77
R9370:Vmn2r81	UTSW	10	79,104,424 (GRCm39)	missense	probably damaging	1.00
R9588:Vmn2r81	UTSW	10	79,129,205 (GRCm39)	missense	possibly damaging	0.46
X0067:Vmn2r81	UTSW	10	79,128,877 (GRCm39)	missense	possibly damaging	0.46

Posted On

2015-04-16