Incidental Mutation 'IGL00980:Wscd1'
ID |
28659 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Wscd1
|
Ensembl Gene |
ENSMUSG00000020811 |
Gene Name |
WSC domain containing 1 |
Synonyms |
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL00980
|
Quality Score |
|
Status
|
|
Chromosome |
11 |
Chromosomal Location |
71640746-71680473 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to C
at 71679768 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Threonine
at position 547
(N547T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000104151
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021168]
[ENSMUST00000108510]
[ENSMUST00000108511]
|
AlphaFold |
Q80XH4 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000021168
AA Change: N547T
PolyPhen 2
Score 0.888 (Sensitivity: 0.82; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000021168 Gene: ENSMUSG00000020811 AA Change: N547T
Domain | Start | End | E-Value | Type |
transmembrane domain
|
17 |
36 |
N/A |
INTRINSIC |
low complexity region
|
100 |
114 |
N/A |
INTRINSIC |
WSC
|
139 |
231 |
8.72e-40 |
SMART |
WSC
|
242 |
337 |
2.09e-28 |
SMART |
Pfam:Sulfotransfer_1
|
413 |
525 |
1.6e-9 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000108510
AA Change: N547T
PolyPhen 2
Score 0.888 (Sensitivity: 0.82; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000104150 Gene: ENSMUSG00000020811 AA Change: N547T
Domain | Start | End | E-Value | Type |
transmembrane domain
|
17 |
36 |
N/A |
INTRINSIC |
low complexity region
|
100 |
114 |
N/A |
INTRINSIC |
WSC
|
139 |
231 |
8.72e-40 |
SMART |
WSC
|
242 |
337 |
2.09e-28 |
SMART |
Pfam:Sulfotransfer_1
|
413 |
525 |
1.6e-9 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000108511
AA Change: N547T
PolyPhen 2
Score 0.888 (Sensitivity: 0.82; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000104151 Gene: ENSMUSG00000020811 AA Change: N547T
Domain | Start | End | E-Value | Type |
transmembrane domain
|
17 |
36 |
N/A |
INTRINSIC |
low complexity region
|
100 |
114 |
N/A |
INTRINSIC |
WSC
|
139 |
231 |
8.72e-40 |
SMART |
WSC
|
242 |
337 |
2.09e-28 |
SMART |
Pfam:Sulfotransfer_1
|
413 |
525 |
1.6e-9 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132095
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 36 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adam2 |
A |
T |
14: 66,293,977 (GRCm39) |
Y283* |
probably null |
Het |
Bend3 |
C |
A |
10: 43,387,562 (GRCm39) |
Q652K |
probably damaging |
Het |
Bltp1 |
C |
T |
3: 37,054,190 (GRCm39) |
T3103I |
probably damaging |
Het |
Ccdc136 |
G |
A |
6: 29,420,257 (GRCm39) |
S992N |
probably damaging |
Het |
Cct6a |
T |
C |
5: 129,868,856 (GRCm39) |
|
probably benign |
Het |
Cd74 |
A |
T |
18: 60,944,398 (GRCm39) |
I203F |
probably benign |
Het |
Cd8b1 |
C |
A |
6: 71,309,463 (GRCm39) |
C182* |
probably null |
Het |
Cmtr1 |
T |
A |
17: 29,910,258 (GRCm39) |
D454E |
probably benign |
Het |
Cyp2b13 |
T |
A |
7: 25,781,152 (GRCm39) |
F188Y |
probably benign |
Het |
Dppa2 |
T |
C |
16: 48,132,049 (GRCm39) |
S49P |
possibly damaging |
Het |
Fhl5 |
G |
T |
4: 25,207,181 (GRCm39) |
L196I |
possibly damaging |
Het |
Gimap4 |
T |
A |
6: 48,667,872 (GRCm39) |
V81D |
probably damaging |
Het |
Gm4884 |
T |
G |
7: 40,693,150 (GRCm39) |
M373R |
probably damaging |
Het |
Gnrhr |
C |
T |
5: 86,345,162 (GRCm39) |
|
probably null |
Het |
H2-Oa |
T |
G |
17: 34,313,537 (GRCm39) |
L196R |
probably damaging |
Het |
Icosl |
T |
C |
10: 77,907,805 (GRCm39) |
S122P |
probably damaging |
Het |
Itpr3 |
A |
G |
17: 27,329,930 (GRCm39) |
T1575A |
probably benign |
Het |
Krt80 |
T |
C |
15: 101,247,879 (GRCm39) |
K373E |
possibly damaging |
Het |
Lamp1 |
G |
A |
8: 13,221,195 (GRCm39) |
|
probably benign |
Het |
Npvf |
T |
C |
6: 50,627,865 (GRCm39) |
K185E |
probably damaging |
Het |
Nuf2 |
A |
G |
1: 169,338,003 (GRCm39) |
M258T |
probably damaging |
Het |
Or6b2 |
T |
C |
1: 92,407,402 (GRCm39) |
|
probably null |
Het |
Or8b36 |
G |
A |
9: 37,937,107 (GRCm39) |
V2I |
probably benign |
Het |
Smurf2 |
A |
C |
11: 106,726,921 (GRCm39) |
I469S |
probably damaging |
Het |
Soat1 |
T |
A |
1: 156,268,911 (GRCm39) |
H180L |
probably benign |
Het |
Spink5 |
G |
T |
18: 44,140,777 (GRCm39) |
D659Y |
probably damaging |
Het |
Sprtn |
T |
C |
8: 125,627,037 (GRCm39) |
M139T |
probably damaging |
Het |
Tas2r140 |
T |
C |
6: 40,468,352 (GRCm39) |
S61P |
possibly damaging |
Het |
Tec |
G |
A |
5: 72,944,141 (GRCm39) |
L89F |
probably damaging |
Het |
Trav21-dv12 |
A |
T |
14: 54,114,107 (GRCm39) |
M76L |
probably benign |
Het |
Ttc7 |
A |
C |
17: 87,628,874 (GRCm39) |
T271P |
possibly damaging |
Het |
Tyk2 |
G |
A |
9: 21,031,884 (GRCm39) |
T397I |
probably benign |
Het |
Ugt1a6b |
T |
A |
1: 88,035,327 (GRCm39) |
Y222N |
possibly damaging |
Het |
Vmn2r2 |
A |
T |
3: 64,024,601 (GRCm39) |
M660K |
probably benign |
Het |
Vmn2r52 |
T |
A |
7: 9,905,017 (GRCm39) |
Y274F |
probably damaging |
Het |
Zfp335 |
C |
A |
2: 164,744,594 (GRCm39) |
E394* |
probably null |
Het |
|
Other mutations in Wscd1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01982:Wscd1
|
APN |
11 |
71,657,699 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL01991:Wscd1
|
APN |
11 |
71,678,549 (GRCm39) |
nonsense |
probably null |
|
IGL02211:Wscd1
|
APN |
11 |
71,679,801 (GRCm39) |
missense |
probably damaging |
1.00 |
R0011:Wscd1
|
UTSW |
11 |
71,679,654 (GRCm39) |
missense |
probably damaging |
1.00 |
R0011:Wscd1
|
UTSW |
11 |
71,679,654 (GRCm39) |
missense |
probably damaging |
1.00 |
R0359:Wscd1
|
UTSW |
11 |
71,657,692 (GRCm39) |
missense |
probably damaging |
1.00 |
R0371:Wscd1
|
UTSW |
11 |
71,679,549 (GRCm39) |
missense |
probably damaging |
1.00 |
R1340:Wscd1
|
UTSW |
11 |
71,659,586 (GRCm39) |
missense |
probably benign |
0.01 |
R1429:Wscd1
|
UTSW |
11 |
71,651,000 (GRCm39) |
missense |
probably damaging |
0.99 |
R1511:Wscd1
|
UTSW |
11 |
71,679,501 (GRCm39) |
missense |
probably damaging |
1.00 |
R1823:Wscd1
|
UTSW |
11 |
71,651,044 (GRCm39) |
missense |
probably benign |
0.05 |
R4772:Wscd1
|
UTSW |
11 |
71,662,802 (GRCm39) |
critical splice donor site |
probably null |
|
R4885:Wscd1
|
UTSW |
11 |
71,650,972 (GRCm39) |
missense |
probably damaging |
1.00 |
R5221:Wscd1
|
UTSW |
11 |
71,659,501 (GRCm39) |
missense |
possibly damaging |
0.53 |
R5714:Wscd1
|
UTSW |
11 |
71,675,261 (GRCm39) |
critical splice donor site |
probably null |
|
R6351:Wscd1
|
UTSW |
11 |
71,650,709 (GRCm39) |
missense |
probably damaging |
1.00 |
R7181:Wscd1
|
UTSW |
11 |
71,650,709 (GRCm39) |
missense |
probably damaging |
1.00 |
R7184:Wscd1
|
UTSW |
11 |
71,679,543 (GRCm39) |
missense |
probably damaging |
1.00 |
R7461:Wscd1
|
UTSW |
11 |
71,650,799 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7613:Wscd1
|
UTSW |
11 |
71,650,799 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7754:Wscd1
|
UTSW |
11 |
71,675,191 (GRCm39) |
missense |
probably damaging |
1.00 |
R7875:Wscd1
|
UTSW |
11 |
71,679,560 (GRCm39) |
missense |
probably damaging |
1.00 |
R8804:Wscd1
|
UTSW |
11 |
71,675,161 (GRCm39) |
missense |
probably damaging |
1.00 |
R9103:Wscd1
|
UTSW |
11 |
71,674,245 (GRCm39) |
critical splice donor site |
probably null |
|
R9220:Wscd1
|
UTSW |
11 |
71,662,750 (GRCm39) |
missense |
probably benign |
0.01 |
R9359:Wscd1
|
UTSW |
11 |
71,650,799 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9473:Wscd1
|
UTSW |
11 |
71,679,644 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1177:Wscd1
|
UTSW |
11 |
71,679,811 (GRCm39) |
missense |
probably damaging |
0.98 |
Z1177:Wscd1
|
UTSW |
11 |
71,679,626 (GRCm39) |
nonsense |
probably null |
|
|
Posted On |
2013-04-17 |