Incidental Mutation 'IGL02257:Or10w1'
ID 286617
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10w1
Ensembl Gene ENSMUSG00000061387
Gene Name olfactory receptor family 10 subfamily W member 1
Synonyms Olfr1490, GA_x6K02T2RE5P-3987000-3987950, MOR266-6P
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # IGL02257
Quality Score
Status
Chromosome 19
Chromosomal Location 13631810-13632760 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 13632629 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 279 (V279I)
Ref Sequence ENSEMBL: ENSMUSP00000151186 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080162] [ENSMUST00000208667] [ENSMUST00000213900]
AlphaFold A0A1L1SVH0
Predicted Effect probably benign
Transcript: ENSMUST00000080162
AA Change: V274I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000079057
Gene: ENSMUSG00000061387
AA Change: V274I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.3e-48 PFAM
Pfam:7tm_1 41 290 2e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208667
AA Change: V279I
Predicted Effect probably benign
Transcript: ENSMUST00000213900
AA Change: V279I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216631
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aanat C T 11: 116,486,535 (GRCm39) Q25* probably null Het
Adam8 A T 7: 139,567,561 (GRCm39) V394D possibly damaging Het
Ahnak2 A G 12: 112,748,905 (GRCm39) F314S possibly damaging Het
Arsg T C 11: 109,412,473 (GRCm39) probably benign Het
Atp13a2 T G 4: 140,733,400 (GRCm39) V958G probably benign Het
Ces5a T C 8: 94,252,226 (GRCm39) D218G probably benign Het
Cntnap4 T A 8: 113,343,126 (GRCm39) L63Q probably damaging Het
Cped1 A G 6: 22,145,606 (GRCm39) T655A possibly damaging Het
Ddc A T 11: 11,823,171 (GRCm39) L133* probably null Het
Fat4 C T 3: 39,055,288 (GRCm39) A4169V probably benign Het
Gnpat T C 8: 125,613,587 (GRCm39) probably benign Het
Gpd2 A G 2: 57,254,536 (GRCm39) D678G probably benign Het
Hk1 T C 10: 62,107,422 (GRCm39) D851G probably benign Het
Hsd11b2 G A 8: 106,249,854 (GRCm39) V322I probably benign Het
Hsd17b3 G A 13: 64,207,276 (GRCm39) T255M probably benign Het
Hsp90b1 T C 10: 86,534,453 (GRCm39) S284G probably damaging Het
Med1 T A 11: 98,071,096 (GRCm39) I69L probably damaging Het
Mmut C T 17: 41,249,625 (GRCm39) T200I possibly damaging Het
Morn3 T G 5: 123,175,788 (GRCm39) D200A probably damaging Het
Mtss1 A G 15: 58,828,394 (GRCm39) V173A probably damaging Het
Myl6b T C 10: 128,333,210 (GRCm39) probably benign Het
Nin A G 12: 70,149,465 (GRCm39) V48A possibly damaging Het
Odr4 A T 1: 150,262,155 (GRCm39) I95N probably damaging Het
Or2n1 G T 17: 38,486,577 (GRCm39) V201L probably benign Het
Phlpp2 T A 8: 110,646,731 (GRCm39) V529E possibly damaging Het
Pnlip G A 19: 58,662,306 (GRCm39) V151I probably benign Het
Pus7 A C 5: 23,967,459 (GRCm39) H247Q probably damaging Het
Setd6 T C 8: 96,443,320 (GRCm39) Y188H probably damaging Het
Siglecg T C 7: 43,061,328 (GRCm39) S444P probably benign Het
Sox9 C A 11: 112,675,811 (GRCm39) H333Q possibly damaging Het
Specc1 T A 11: 62,009,243 (GRCm39) I333N probably damaging Het
Tmprss11e G A 5: 86,872,039 (GRCm39) T59I probably damaging Het
Vmn2r93 A C 17: 18,545,770 (GRCm39) probably benign Het
Vrk2 A T 11: 26,484,266 (GRCm39) V163D probably damaging Het
Other mutations in Or10w1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01324:Or10w1 APN 19 13,632,297 (GRCm39) missense probably damaging 0.96
IGL01335:Or10w1 APN 19 13,632,540 (GRCm39) missense probably damaging 1.00
IGL01561:Or10w1 APN 19 13,632,269 (GRCm39) missense probably benign
IGL01644:Or10w1 APN 19 13,632,768 (GRCm39) utr 3 prime probably benign
IGL02282:Or10w1 APN 19 13,632,622 (GRCm39) missense probably damaging 1.00
IGL02355:Or10w1 APN 19 13,632,597 (GRCm39) missense probably benign 0.02
IGL02362:Or10w1 APN 19 13,632,597 (GRCm39) missense probably benign 0.02
IGL02639:Or10w1 APN 19 13,631,960 (GRCm39) missense possibly damaging 0.73
R0078:Or10w1 UTSW 19 13,632,179 (GRCm39) missense probably benign 0.00
R0278:Or10w1 UTSW 19 13,632,129 (GRCm39) missense probably damaging 1.00
R0278:Or10w1 UTSW 19 13,632,128 (GRCm39) missense probably damaging 1.00
R0506:Or10w1 UTSW 19 13,632,261 (GRCm39) missense possibly damaging 0.62
R0927:Or10w1 UTSW 19 13,631,816 (GRCm39) missense probably damaging 0.99
R1087:Or10w1 UTSW 19 13,632,376 (GRCm39) nonsense probably null
R1762:Or10w1 UTSW 19 13,631,868 (GRCm39) missense probably benign
R2901:Or10w1 UTSW 19 13,632,309 (GRCm39) missense probably damaging 1.00
R2907:Or10w1 UTSW 19 13,632,611 (GRCm39) missense possibly damaging 0.84
R3625:Or10w1 UTSW 19 13,632,346 (GRCm39) nonsense probably null
R3838:Or10w1 UTSW 19 13,632,321 (GRCm39) missense probably benign 0.00
R4745:Or10w1 UTSW 19 13,632,750 (GRCm39) missense probably benign
R4804:Or10w1 UTSW 19 13,631,882 (GRCm39) missense probably benign
R5026:Or10w1 UTSW 19 13,632,296 (GRCm39) missense probably benign 0.03
R5314:Or10w1 UTSW 19 13,632,630 (GRCm39) missense probably benign 0.08
R6052:Or10w1 UTSW 19 13,631,871 (GRCm39) missense possibly damaging 0.95
R6235:Or10w1 UTSW 19 13,632,145 (GRCm39) nonsense probably null
R7405:Or10w1 UTSW 19 13,632,246 (GRCm39) missense probably benign 0.14
R7557:Or10w1 UTSW 19 13,632,390 (GRCm39) missense possibly damaging 0.71
R8038:Or10w1 UTSW 19 13,632,719 (GRCm39) missense possibly damaging 0.91
R8338:Or10w1 UTSW 19 13,632,216 (GRCm39) missense possibly damaging 0.92
R8366:Or10w1 UTSW 19 13,631,903 (GRCm39) missense probably damaging 1.00
R8496:Or10w1 UTSW 19 13,632,388 (GRCm39) missense probably damaging 0.96
R8783:Or10w1 UTSW 19 13,632,323 (GRCm39) missense probably damaging 1.00
R8838:Or10w1 UTSW 19 13,632,371 (GRCm39) missense probably damaging 0.98
R8859:Or10w1 UTSW 19 13,632,246 (GRCm39) missense probably damaging 0.99
R9064:Or10w1 UTSW 19 13,632,719 (GRCm39) missense possibly damaging 0.91
R9161:Or10w1 UTSW 19 13,632,038 (GRCm39) missense probably damaging 1.00
R9466:Or10w1 UTSW 19 13,631,796 (GRCm39) start codon destroyed probably null
R9596:Or10w1 UTSW 19 13,632,002 (GRCm39) missense probably damaging 1.00
R9623:Or10w1 UTSW 19 13,632,414 (GRCm39) missense probably damaging 1.00
Z1176:Or10w1 UTSW 19 13,631,827 (GRCm39) missense probably benign 0.00
Posted On 2015-04-16