Incidental Mutation 'IGL02257:Or2n1'
ID 286619
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2n1
Ensembl Gene ENSMUSG00000096009
Gene Name olfactory receptor family 2 subfamily N member 1
Synonyms GA_x6K02T2PSCP-2623613-2624551, MOR256-5, Olfr134
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # IGL02257
Quality Score
Status
Chromosome 17
Chromosomal Location 38485977-38486915 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 38486577 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 201 (V201L)
Ref Sequence ENSEMBL: ENSMUSP00000151069 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074883] [ENSMUST00000215900]
AlphaFold Q8VG95
Predicted Effect probably benign
Transcript: ENSMUST00000074883
AA Change: V201L

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000074423
Gene: ENSMUSG00000096009
AA Change: V201L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.4e-50 PFAM
Pfam:7tm_1 41 290 2e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215900
AA Change: V201L

PolyPhen 2 Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aanat C T 11: 116,486,535 (GRCm39) Q25* probably null Het
Adam8 A T 7: 139,567,561 (GRCm39) V394D possibly damaging Het
Ahnak2 A G 12: 112,748,905 (GRCm39) F314S possibly damaging Het
Arsg T C 11: 109,412,473 (GRCm39) probably benign Het
Atp13a2 T G 4: 140,733,400 (GRCm39) V958G probably benign Het
Ces5a T C 8: 94,252,226 (GRCm39) D218G probably benign Het
Cntnap4 T A 8: 113,343,126 (GRCm39) L63Q probably damaging Het
Cped1 A G 6: 22,145,606 (GRCm39) T655A possibly damaging Het
Ddc A T 11: 11,823,171 (GRCm39) L133* probably null Het
Fat4 C T 3: 39,055,288 (GRCm39) A4169V probably benign Het
Gnpat T C 8: 125,613,587 (GRCm39) probably benign Het
Gpd2 A G 2: 57,254,536 (GRCm39) D678G probably benign Het
Hk1 T C 10: 62,107,422 (GRCm39) D851G probably benign Het
Hsd11b2 G A 8: 106,249,854 (GRCm39) V322I probably benign Het
Hsd17b3 G A 13: 64,207,276 (GRCm39) T255M probably benign Het
Hsp90b1 T C 10: 86,534,453 (GRCm39) S284G probably damaging Het
Med1 T A 11: 98,071,096 (GRCm39) I69L probably damaging Het
Mmut C T 17: 41,249,625 (GRCm39) T200I possibly damaging Het
Morn3 T G 5: 123,175,788 (GRCm39) D200A probably damaging Het
Mtss1 A G 15: 58,828,394 (GRCm39) V173A probably damaging Het
Myl6b T C 10: 128,333,210 (GRCm39) probably benign Het
Nin A G 12: 70,149,465 (GRCm39) V48A possibly damaging Het
Odr4 A T 1: 150,262,155 (GRCm39) I95N probably damaging Het
Or10w1 G A 19: 13,632,629 (GRCm39) V279I probably benign Het
Phlpp2 T A 8: 110,646,731 (GRCm39) V529E possibly damaging Het
Pnlip G A 19: 58,662,306 (GRCm39) V151I probably benign Het
Pus7 A C 5: 23,967,459 (GRCm39) H247Q probably damaging Het
Setd6 T C 8: 96,443,320 (GRCm39) Y188H probably damaging Het
Siglecg T C 7: 43,061,328 (GRCm39) S444P probably benign Het
Sox9 C A 11: 112,675,811 (GRCm39) H333Q possibly damaging Het
Specc1 T A 11: 62,009,243 (GRCm39) I333N probably damaging Het
Tmprss11e G A 5: 86,872,039 (GRCm39) T59I probably damaging Het
Vmn2r93 A C 17: 18,545,770 (GRCm39) probably benign Het
Vrk2 A T 11: 26,484,266 (GRCm39) V163D probably damaging Het
Other mutations in Or2n1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01677:Or2n1 APN 17 38,486,766 (GRCm39) missense probably damaging 1.00
IGL01749:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01750:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01751:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01753:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01757:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01765:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01766:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01767:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01822:Or2n1 APN 17 38,486,339 (GRCm39) missense probably damaging 1.00
IGL02256:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02258:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02259:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02275:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02293:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02295:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02317:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02318:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
R0230:Or2n1 UTSW 17 38,486,841 (GRCm39) missense probably damaging 1.00
R0363:Or2n1 UTSW 17 38,486,338 (GRCm39) missense probably damaging 1.00
R1074:Or2n1 UTSW 17 38,486,331 (GRCm39) missense probably damaging 1.00
R1506:Or2n1 UTSW 17 38,486,091 (GRCm39) missense probably benign
R2300:Or2n1 UTSW 17 38,486,441 (GRCm39) nonsense probably null
R3743:Or2n1 UTSW 17 38,486,793 (GRCm39) missense probably damaging 1.00
R3975:Or2n1 UTSW 17 38,486,386 (GRCm39) missense probably benign 0.03
R4230:Or2n1 UTSW 17 38,486,772 (GRCm39) missense possibly damaging 0.67
R5158:Or2n1 UTSW 17 38,486,345 (GRCm39) nonsense probably null
R5439:Or2n1 UTSW 17 38,486,917 (GRCm39) splice site probably null
R6144:Or2n1 UTSW 17 38,486,116 (GRCm39) missense probably damaging 1.00
R6309:Or2n1 UTSW 17 38,486,410 (GRCm39) missense probably benign 0.00
R6675:Or2n1 UTSW 17 38,486,905 (GRCm39) missense probably benign
R6800:Or2n1 UTSW 17 38,486,013 (GRCm39) missense probably benign 0.01
R6873:Or2n1 UTSW 17 38,486,259 (GRCm39) missense probably benign
R7193:Or2n1 UTSW 17 38,485,987 (GRCm39) missense probably benign 0.44
R7534:Or2n1 UTSW 17 38,486,188 (GRCm39) missense probably benign 0.22
R7869:Or2n1 UTSW 17 38,486,830 (GRCm39) missense possibly damaging 0.94
R7912:Or2n1 UTSW 17 38,486,158 (GRCm39) missense probably damaging 0.99
R8048:Or2n1 UTSW 17 38,486,419 (GRCm39) missense probably benign 0.11
R8305:Or2n1 UTSW 17 38,486,464 (GRCm39) missense probably damaging 1.00
R9396:Or2n1 UTSW 17 38,486,421 (GRCm39) missense probably damaging 1.00
R9445:Or2n1 UTSW 17 38,486,694 (GRCm39) missense probably damaging 1.00
X0011:Or2n1 UTSW 17 38,486,742 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16