Incidental Mutation 'IGL02258:Hist1h2bg'
ID286650
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Hist1h2bg
Ensembl Gene ENSMUSG00000058385
Gene Namehistone cluster 1, H2bg
Synonyms
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL02258
Quality Score
Status
Chromosome13
Chromosomal Location23571396-23572013 bp(+) (GRCm38)
Type of Mutationstart codon destroyed
DNA Base Change (assembly) G to T at 23571435 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Isoleucine at position 1 (M1I)
Ref Sequence ENSEMBL: ENSMUSP00000078239 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079251] [ENSMUST00000090776] [ENSMUST00000102969] [ENSMUST00000105105] [ENSMUST00000105106]
Predicted Effect probably null
Transcript: ENSMUST00000079251
AA Change: M1I
SMART Domains Protein: ENSMUSP00000078239
Gene: ENSMUSG00000058385
AA Change: M1I

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
H2B 28 124 1.43e-72 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000090776
SMART Domains Protein: ENSMUSP00000088281
Gene: ENSMUSG00000071478

DomainStartEndE-ValueType
H2A 3 123 8.07e-81 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102969
SMART Domains Protein: ENSMUSP00000100034
Gene: ENSMUSG00000069272

DomainStartEndE-ValueType
H2A 3 123 8.07e-81 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000105105
SMART Domains Protein: ENSMUSP00000100737
Gene: ENSMUSG00000099583

DomainStartEndE-ValueType
H3 34 136 2.12e-75 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000105106
SMART Domains Protein: ENSMUSP00000100738
Gene: ENSMUSG00000069268

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
H2B 28 124 4.64e-72 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199558
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200671
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Allele List at MGI
Other mutations in this stock
Total: 7 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Diaph1 G T 18: 37,853,330 R1166S probably damaging Het
Fosl2 C A 5: 32,146,915 Q65K probably damaging Het
Il18 A G 9: 50,576,703 N29S probably benign Het
Olfr134 G T 17: 38,175,686 V201L probably benign Het
Olfr849 T A 9: 19,440,997 F28Y possibly damaging Het
Olfr849 A T 9: 19,440,999 T29S probably benign Het
Psg16 A G 7: 17,095,292 D267G probably damaging Het
Other mutations in Hist1h2bg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02254:Hist1h2bg APN 13 23571435 start codon destroyed probably null
IGL02256:Hist1h2bg APN 13 23571435 start codon destroyed probably null
PIT4508001:Hist1h2bg UTSW 13 23571693 unclassified probably benign
R3625:Hist1h2bg UTSW 13 23571451 unclassified probably benign
R7295:Hist1h2bg UTSW 13 23571769 missense probably benign 0.44
R7506:Hist1h2bg UTSW 13 23571484 missense unknown
Posted On2015-04-16