Incidental Mutation 'IGL02258:H2bc8'
ID 286650
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol H2bc8
Ensembl Gene ENSMUSG00000058385
Gene Name H2B clustered histone 8
Synonyms Hist1h2bg
Accession Numbers
Essential gene? Not available question?
Stock # IGL02258
Quality Score
Status
Chromosome 13
Chromosomal Location 23755574-23756037 bp(+) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) G to T at 23755609 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 1 (M1I)
Ref Sequence ENSEMBL: ENSMUSP00000078239 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079251] [ENSMUST00000090776] [ENSMUST00000102969] [ENSMUST00000105105] [ENSMUST00000105106]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000079251
AA Change: M1I
SMART Domains Protein: ENSMUSP00000078239
Gene: ENSMUSG00000058385
AA Change: M1I

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
H2B 28 124 1.43e-72 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000090776
SMART Domains Protein: ENSMUSP00000088281
Gene: ENSMUSG00000071478

DomainStartEndE-ValueType
H2A 3 123 8.07e-81 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102969
SMART Domains Protein: ENSMUSP00000100034
Gene: ENSMUSG00000069272

DomainStartEndE-ValueType
H2A 3 123 8.07e-81 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000105105
SMART Domains Protein: ENSMUSP00000100737
Gene: ENSMUSG00000099583

DomainStartEndE-ValueType
H3 34 136 2.12e-75 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000105106
SMART Domains Protein: ENSMUSP00000100738
Gene: ENSMUSG00000069268

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
H2B 28 124 4.64e-72 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199558
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200671
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Allele List at MGI
Other mutations in this stock
Total: 7 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Diaph1 G T 18: 37,986,383 (GRCm39) R1166S probably damaging Het
Fosl2 C A 5: 32,304,259 (GRCm39) Q65K probably damaging Het
Il18 A G 9: 50,488,003 (GRCm39) N29S probably benign Het
Or2n1 G T 17: 38,486,577 (GRCm39) V201L probably benign Het
Or7g30 T A 9: 19,352,293 (GRCm39) F28Y possibly damaging Het
Or7g30 A T 9: 19,352,295 (GRCm39) T29S probably benign Het
Psg16 A G 7: 16,829,217 (GRCm39) D267G probably damaging Het
Other mutations in H2bc8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02254:H2bc8 APN 13 23,755,609 (GRCm39) start codon destroyed probably null
IGL02256:H2bc8 APN 13 23,755,609 (GRCm39) start codon destroyed probably null
PIT4508001:H2bc8 UTSW 13 23,755,867 (GRCm39) unclassified probably benign
R3625:H2bc8 UTSW 13 23,755,625 (GRCm39) unclassified probably benign
R7295:H2bc8 UTSW 13 23,755,943 (GRCm39) missense probably benign 0.44
R7506:H2bc8 UTSW 13 23,755,658 (GRCm39) missense unknown
R8050:H2bc8 UTSW 13 23,755,841 (GRCm39) missense probably damaging 1.00
R8499:H2bc8 UTSW 13 23,755,880 (GRCm39) missense probably benign 0.06
R9189:H2bc8 UTSW 13 23,755,761 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16