Incidental Mutation 'IGL02259:Zfp879'
ID286660
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp879
Ensembl Gene ENSMUSG00000044296
Gene Namezinc finger protein 879
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02259
Quality Score
Status
Chromosome11
Chromosomal Location50832031-50841552 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 50838428 bp
ZygosityHeterozygous
Amino Acid Change Serine to Glycine at position 48 (S48G)
Ref Sequence ENSEMBL: ENSMUSP00000104762 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049625] [ENSMUST00000109133] [ENSMUST00000109134]
Predicted Effect probably benign
Transcript: ENSMUST00000049625
AA Change: S48G

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000061782
Gene: ENSMUSG00000044296
AA Change: S48G

DomainStartEndE-ValueType
KRAB 14 74 1.54e-33 SMART
ZnF_C2H2 204 226 1.92e-2 SMART
ZnF_C2H2 232 254 1.38e-3 SMART
ZnF_C2H2 260 282 1.16e-1 SMART
ZnF_C2H2 288 310 4.54e-4 SMART
ZnF_C2H2 316 338 8.34e-3 SMART
ZnF_C2H2 344 366 4.87e-4 SMART
ZnF_C2H2 372 394 8.47e-4 SMART
ZnF_C2H2 400 422 1.84e-4 SMART
ZnF_C2H2 428 450 2.57e-3 SMART
ZnF_C2H2 456 478 1.47e-3 SMART
ZnF_C2H2 484 506 3.21e-4 SMART
ZnF_C2H2 512 534 1.5e-4 SMART
ZnF_C2H2 540 562 5.21e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000109133
SMART Domains Protein: ENSMUSP00000104761
Gene: ENSMUSG00000044296

DomainStartEndE-ValueType
ZnF_C2H2 131 153 1.92e-2 SMART
ZnF_C2H2 159 181 1.38e-3 SMART
ZnF_C2H2 187 209 1.16e-1 SMART
ZnF_C2H2 215 237 4.54e-4 SMART
ZnF_C2H2 243 265 8.34e-3 SMART
ZnF_C2H2 271 293 4.87e-4 SMART
ZnF_C2H2 299 321 8.47e-4 SMART
ZnF_C2H2 327 349 1.84e-4 SMART
ZnF_C2H2 355 377 2.57e-3 SMART
ZnF_C2H2 383 405 1.47e-3 SMART
ZnF_C2H2 411 433 3.21e-4 SMART
ZnF_C2H2 439 461 1.5e-4 SMART
ZnF_C2H2 467 489 5.21e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000109134
AA Change: S48G

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000104762
Gene: ENSMUSG00000044296
AA Change: S48G

DomainStartEndE-ValueType
KRAB 14 74 1.54e-33 SMART
ZnF_C2H2 204 226 1.92e-2 SMART
ZnF_C2H2 232 254 1.38e-3 SMART
ZnF_C2H2 260 282 1.16e-1 SMART
ZnF_C2H2 288 310 4.54e-4 SMART
ZnF_C2H2 316 338 8.34e-3 SMART
ZnF_C2H2 344 366 4.87e-4 SMART
ZnF_C2H2 372 394 8.47e-4 SMART
ZnF_C2H2 400 422 1.84e-4 SMART
ZnF_C2H2 428 450 2.57e-3 SMART
ZnF_C2H2 456 478 1.47e-3 SMART
ZnF_C2H2 484 506 3.21e-4 SMART
ZnF_C2H2 512 534 1.5e-4 SMART
ZnF_C2H2 540 562 5.21e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AF529169 A T 9: 89,602,359 H328Q possibly damaging Het
Ang6 A G 14: 44,001,906 F122L probably benign Het
Atm A T 9: 53,518,494 probably benign Het
Ccsap G A 8: 123,845,427 T112M possibly damaging Het
Cd63 T C 10: 128,911,974 S113P probably benign Het
Cntnap5c T C 17: 58,034,862 F183L probably damaging Het
Cux1 T A 5: 136,326,833 S321C probably damaging Het
Cyp2ab1 G A 16: 20,313,147 T281I probably damaging Het
Cyp2c40 A C 19: 39,803,802 C233G probably benign Het
Dnah8 T C 17: 30,759,614 I2955T probably benign Het
Drc7 A G 8: 95,056,105 T33A probably benign Het
Gigyf2 T A 1: 87,411,837 Y481N probably damaging Het
Gsap A T 5: 21,186,400 E13V probably benign Het
Ifna4 A G 4: 88,842,056 K66E probably damaging Het
Kif14 T A 1: 136,500,102 M1103K probably benign Het
Kif6 A T 17: 49,895,891 probably benign Het
Lsm14a G T 7: 34,371,133 P113T probably damaging Het
Med12l T A 3: 59,245,843 N1096K probably damaging Het
Med13 C A 11: 86,357,501 G9W possibly damaging Het
Nbr1 G A 11: 101,577,990 A639T probably damaging Het
Nid2 G T 14: 19,768,209 probably null Het
Numa1 A G 7: 101,987,748 D22G possibly damaging Het
Olfr134 G T 17: 38,175,686 V201L probably benign Het
Olfr62 G A 4: 118,666,437 V307I probably benign Het
Phkg2 A G 7: 127,582,286 probably benign Het
Plcb4 T C 2: 135,910,246 probably null Het
Plch1 C T 3: 63,722,749 probably null Het
Prl8a1 A C 13: 27,582,106 V2G probably benign Het
Prpmp5 A T 6: 132,312,674 D62E unknown Het
Spata31 T C 13: 64,921,483 S482P possibly damaging Het
Tbc1d4 A G 14: 101,465,730 C760R probably damaging Het
Tgs1 A G 4: 3,604,743 N722D probably damaging Het
Tmcc2 T C 1: 132,361,160 D28G probably benign Het
Zfp457 C T 13: 67,296,407 A11T possibly damaging Het
Other mutations in Zfp879
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01659:Zfp879 APN 11 50838454 missense probably damaging 1.00
IGL02175:Zfp879 APN 11 50837916 missense probably benign 0.13
R0131:Zfp879 UTSW 11 50833599 missense probably damaging 1.00
R1430:Zfp879 UTSW 11 50833957 missense probably benign 0.00
R1576:Zfp879 UTSW 11 50833549 missense probably benign 0.41
R1616:Zfp879 UTSW 11 50832646 missense probably benign 0.06
R1701:Zfp879 UTSW 11 50833233 missense possibly damaging 0.77
R1965:Zfp879 UTSW 11 50833528 missense probably damaging 1.00
R2057:Zfp879 UTSW 11 50832601 missense probably benign
R2058:Zfp879 UTSW 11 50832601 missense probably benign
R2219:Zfp879 UTSW 11 50833267 missense probably damaging 1.00
R3110:Zfp879 UTSW 11 50833162 missense possibly damaging 0.87
R3112:Zfp879 UTSW 11 50833162 missense possibly damaging 0.87
R4658:Zfp879 UTSW 11 50833197 missense probably damaging 1.00
R4845:Zfp879 UTSW 11 50833845 missense probably damaging 1.00
R4998:Zfp879 UTSW 11 50837969 missense probably damaging 1.00
R6362:Zfp879 UTSW 11 50838475 missense probably damaging 0.98
R6930:Zfp879 UTSW 11 50833012 missense probably damaging 1.00
R7091:Zfp879 UTSW 11 50833395 missense probably damaging 0.99
R7186:Zfp879 UTSW 11 50833794 missense probably benign 0.06
R7218:Zfp879 UTSW 11 50832681 missense possibly damaging 0.61
R8138:Zfp879 UTSW 11 50833448 nonsense probably null
X0066:Zfp879 UTSW 11 50833087 missense possibly damaging 0.89
Z1177:Zfp879 UTSW 11 50833431 missense probably damaging 1.00
Posted On2015-04-16