Incidental Mutation 'IGL02259:Zfp879'
| ID |
286660 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp879
|
| Ensembl Gene |
ENSMUSG00000044296 |
| Gene Name |
zinc finger protein 879 |
| Synonyms |
9630041N07Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02259
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
11 |
| Chromosomal Location |
50722858-50732379 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 50729255 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 48
(S48G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104762
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000049625]
[ENSMUST00000109133]
[ENSMUST00000109134]
|
| AlphaFold |
Q8BI99 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000049625
AA Change: S48G
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000061782
Gene: ENSMUSG00000044296
AA Change: S48G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
1.54e-33 |
SMART |
|
ZnF_C2H2
|
204 |
226 |
1.92e-2 |
SMART |
|
ZnF_C2H2
|
232 |
254 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
260 |
282 |
1.16e-1 |
SMART |
|
ZnF_C2H2
|
288 |
310 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
316 |
338 |
8.34e-3 |
SMART |
|
ZnF_C2H2
|
344 |
366 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
372 |
394 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
400 |
422 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
428 |
450 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
456 |
478 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
484 |
506 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
512 |
534 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
540 |
562 |
5.21e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109133
|
| SMART Domains |
Protein: ENSMUSP00000104761
Gene: ENSMUSG00000044296
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
131 |
153 |
1.92e-2 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
1.16e-1 |
SMART |
|
ZnF_C2H2
|
215 |
237 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
243 |
265 |
8.34e-3 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
299 |
321 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
327 |
349 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
355 |
377 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
383 |
405 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
439 |
461 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
467 |
489 |
5.21e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109134
AA Change: S48G
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000104762
Gene: ENSMUSG00000044296
AA Change: S48G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
1.54e-33 |
SMART |
|
ZnF_C2H2
|
204 |
226 |
1.92e-2 |
SMART |
|
ZnF_C2H2
|
232 |
254 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
260 |
282 |
1.16e-1 |
SMART |
|
ZnF_C2H2
|
288 |
310 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
316 |
338 |
8.34e-3 |
SMART |
|
ZnF_C2H2
|
344 |
366 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
372 |
394 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
400 |
422 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
428 |
450 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
456 |
478 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
484 |
506 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
512 |
534 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
540 |
562 |
5.21e-4 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ang6 |
A |
G |
14: 44,239,363 (GRCm39) |
F122L |
probably benign |
Het |
| Atm |
A |
T |
9: 53,429,794 (GRCm39) |
|
probably benign |
Het |
| Ccsap |
G |
A |
8: 124,572,166 (GRCm39) |
T112M |
possibly damaging |
Het |
| Cd63 |
T |
C |
10: 128,747,843 (GRCm39) |
S113P |
probably benign |
Het |
| Cntnap5c |
T |
C |
17: 58,341,857 (GRCm39) |
F183L |
probably damaging |
Het |
| Cux1 |
T |
A |
5: 136,355,687 (GRCm39) |
S321C |
probably damaging |
Het |
| Cyp2ab1 |
G |
A |
16: 20,131,897 (GRCm39) |
T281I |
probably damaging |
Het |
| Cyp2c40 |
A |
C |
19: 39,792,246 (GRCm39) |
C233G |
probably benign |
Het |
| Dnah8 |
T |
C |
17: 30,978,588 (GRCm39) |
I2955T |
probably benign |
Het |
| Drc7 |
A |
G |
8: 95,782,733 (GRCm39) |
T33A |
probably benign |
Het |
| Gigyf2 |
T |
A |
1: 87,339,559 (GRCm39) |
Y481N |
probably damaging |
Het |
| Gsap |
A |
T |
5: 21,391,398 (GRCm39) |
E13V |
probably benign |
Het |
| Ifna4 |
A |
G |
4: 88,760,293 (GRCm39) |
K66E |
probably damaging |
Het |
| Kif14 |
T |
A |
1: 136,427,840 (GRCm39) |
M1103K |
probably benign |
Het |
| Kif6 |
A |
T |
17: 50,202,919 (GRCm39) |
|
probably benign |
Het |
| Lsm14a |
G |
T |
7: 34,070,558 (GRCm39) |
P113T |
probably damaging |
Het |
| Med12l |
T |
A |
3: 59,153,264 (GRCm39) |
N1096K |
probably damaging |
Het |
| Med13 |
C |
A |
11: 86,248,327 (GRCm39) |
G9W |
possibly damaging |
Het |
| Minar1 |
A |
T |
9: 89,484,412 (GRCm39) |
H328Q |
possibly damaging |
Het |
| Nbr1 |
G |
A |
11: 101,468,816 (GRCm39) |
A639T |
probably damaging |
Het |
| Nid2 |
G |
T |
14: 19,818,277 (GRCm39) |
|
probably null |
Het |
| Numa1 |
A |
G |
7: 101,636,955 (GRCm39) |
D22G |
possibly damaging |
Het |
| Or13p10 |
G |
A |
4: 118,523,634 (GRCm39) |
V307I |
probably benign |
Het |
| Or2n1 |
G |
T |
17: 38,486,577 (GRCm39) |
V201L |
probably benign |
Het |
| Phkg2 |
A |
G |
7: 127,181,458 (GRCm39) |
|
probably benign |
Het |
| Plcb4 |
T |
C |
2: 135,752,166 (GRCm39) |
|
probably null |
Het |
| Plch1 |
C |
T |
3: 63,630,170 (GRCm39) |
|
probably null |
Het |
| Prb1b |
A |
T |
6: 132,289,637 (GRCm39) |
D62E |
unknown |
Het |
| Prl8a1 |
A |
C |
13: 27,766,089 (GRCm39) |
V2G |
probably benign |
Het |
| Spata31 |
T |
C |
13: 65,069,297 (GRCm39) |
S482P |
possibly damaging |
Het |
| Tbc1d4 |
A |
G |
14: 101,703,166 (GRCm39) |
C760R |
probably damaging |
Het |
| Tgs1 |
A |
G |
4: 3,604,743 (GRCm39) |
N722D |
probably damaging |
Het |
| Tmcc2 |
T |
C |
1: 132,288,898 (GRCm39) |
D28G |
probably benign |
Het |
| Zfp457 |
C |
T |
13: 67,444,471 (GRCm39) |
A11T |
possibly damaging |
Het |
|
| Other mutations in Zfp879 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01659:Zfp879
|
APN |
11 |
50,729,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02175:Zfp879
|
APN |
11 |
50,728,743 (GRCm39) |
missense |
probably benign |
0.13 |
|
Bazooka
|
UTSW |
11 |
50,729,302 (GRCm39) |
missense |
probably damaging |
0.98 |
|
joe
|
UTSW |
11 |
50,724,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0131:Zfp879
|
UTSW |
11 |
50,724,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1430:Zfp879
|
UTSW |
11 |
50,724,784 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1576:Zfp879
|
UTSW |
11 |
50,724,376 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1616:Zfp879
|
UTSW |
11 |
50,723,473 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1701:Zfp879
|
UTSW |
11 |
50,724,060 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1965:Zfp879
|
UTSW |
11 |
50,724,355 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2057:Zfp879
|
UTSW |
11 |
50,723,428 (GRCm39) |
missense |
probably benign |
|
|
R2058:Zfp879
|
UTSW |
11 |
50,723,428 (GRCm39) |
missense |
probably benign |
|
|
R2219:Zfp879
|
UTSW |
11 |
50,724,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3110:Zfp879
|
UTSW |
11 |
50,723,989 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3112:Zfp879
|
UTSW |
11 |
50,723,989 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4658:Zfp879
|
UTSW |
11 |
50,724,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4845:Zfp879
|
UTSW |
11 |
50,724,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4998:Zfp879
|
UTSW |
11 |
50,728,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6362:Zfp879
|
UTSW |
11 |
50,729,302 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6930:Zfp879
|
UTSW |
11 |
50,723,839 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7091:Zfp879
|
UTSW |
11 |
50,724,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7186:Zfp879
|
UTSW |
11 |
50,724,621 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7218:Zfp879
|
UTSW |
11 |
50,723,508 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R8138:Zfp879
|
UTSW |
11 |
50,724,275 (GRCm39) |
nonsense |
probably null |
|
|
R8445:Zfp879
|
UTSW |
11 |
50,724,213 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8523:Zfp879
|
UTSW |
11 |
50,728,757 (GRCm39) |
missense |
probably benign |
|
|
R8725:Zfp879
|
UTSW |
11 |
50,729,321 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8790:Zfp879
|
UTSW |
11 |
50,723,429 (GRCm39) |
nonsense |
probably null |
|
|
R8882:Zfp879
|
UTSW |
11 |
50,724,763 (GRCm39) |
nonsense |
probably null |
|
|
R9229:Zfp879
|
UTSW |
11 |
50,723,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0066:Zfp879
|
UTSW |
11 |
50,723,914 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
Z1177:Zfp879
|
UTSW |
11 |
50,724,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation