Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02260:Or5m9b'

286698

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5m9b

Ensembl Gene

ENSMUSG00000099820

Gene Name

olfactory receptor family 5 subfamily M member 9B

Synonyms

Olfr1036, GA_x6K02T2Q125-47549689-47550621, MOR262-13, MOR245-25

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.284) question?

Stock #

IGL02260

Quality Score

Status

Chromosome

Chromosomal Location

85905048-85906062 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 85905816 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 244 (T244K)

Ref Sequence

ENSEMBL: ENSMUSP00000130843 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164985]

AlphaFold

Q7TR85

Predicted Effect

possibly damaging
Transcript: ENSMUST00000164985
AA Change: T244K

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000130843
Gene: ENSMUSG00000099820
AA Change: T244K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	2.2e-51	PFAM
Pfam:7tm_1	39	288	1.1e-21	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgre1	C	T	17: 57,754,891 (GRCm39)	A663V	probably benign	Het
Atg2b	A	T	12: 105,602,699 (GRCm39)		probably benign	Het
B4galt6	T	C	18: 20,833,804 (GRCm39)	I194V	probably benign	Het
Caprin1	T	C	2: 103,609,714 (GRCm39)	Y188C	probably damaging	Het
Ccdc85a	A	G	11: 28,526,672 (GRCm39)	F284S	possibly damaging	Het
Ccdc88b	A	T	19: 6,832,717 (GRCm39)		probably benign	Het
Cox18	C	T	5: 90,365,384 (GRCm39)	V272I	possibly damaging	Het
Dars1	A	T	1: 128,299,898 (GRCm39)	M362K	probably benign	Het
Ddi1	A	T	9: 6,265,760 (GRCm39)	M203K	probably benign	Het
Dlg4	G	A	11: 69,933,093 (GRCm39)	G500R	probably damaging	Het
Ebf3	G	A	7: 136,807,919 (GRCm39)	P375S	probably damaging	Het
Eif5b	T	A	1: 38,084,537 (GRCm39)	L842M	possibly damaging	Het
Fhdc1	G	A	3: 84,352,042 (GRCm39)	A1061V	possibly damaging	Het
Gm5581	T	C	6: 131,144,909 (GRCm39)		noncoding transcript	Het
Mapk10	A	T	5: 103,186,534 (GRCm39)	D29E	probably benign	Het
Mib2	C	T	4: 155,745,628 (GRCm39)	R61H	probably damaging	Het
Mki67	A	G	7: 135,303,697 (GRCm39)	S724P	probably benign	Het
Mtor	T	C	4: 148,622,758 (GRCm39)	I1946T	probably damaging	Het
Myh14	A	G	7: 44,260,995 (GRCm39)	L1873P	probably damaging	Het
Myom1	C	T	17: 71,415,310 (GRCm39)	Q1226*	probably null	Het
Neb	A	G	2: 52,095,668 (GRCm39)	L4858P	probably damaging	Het
Or51f5	A	T	7: 102,424,114 (GRCm39)	I128F	probably damaging	Het
Or5p76	T	C	7: 108,122,492 (GRCm39)	I222V	probably benign	Het
Pcdhb14	C	T	18: 37,583,086 (GRCm39)	H731Y	probably benign	Het
Prdm16	T	C	4: 154,412,744 (GRCm39)	N1087S	probably benign	Het
Prdm2	C	T	4: 142,861,157 (GRCm39)	G711D	probably damaging	Het
Proser1	G	A	3: 53,386,365 (GRCm39)	G749D	probably damaging	Het
Ptch1	A	T	13: 63,713,166 (GRCm39)		probably benign	Het
Pus10	A	T	11: 23,657,548 (GRCm39)	K233*	probably null	Het
Rasa2	A	G	9: 96,426,372 (GRCm39)	Y825H	probably benign	Het
Tbcd	T	C	11: 121,494,104 (GRCm39)	F969S	probably damaging	Het
Tbp	T	A	17: 15,724,878 (GRCm39)	S133T	probably damaging	Het
Tnks	C	T	8: 35,310,137 (GRCm39)	G1062D	probably damaging	Het
Tnrc6b	T	A	15: 80,764,372 (GRCm39)	S625T	probably damaging	Het
Triobp	T	C	15: 78,850,562 (GRCm39)	S239P	probably benign	Het
Ubiad1	T	C	4: 148,528,564 (GRCm39)	D115G	probably benign	Het
Uckl1	A	G	2: 181,211,381 (GRCm39)	S483P	probably damaging	Het
Vill	A	G	9: 118,887,509 (GRCm39)	D91G	probably benign	Het
Wdr62	C	A	7: 29,970,207 (GRCm39)	C200F	probably damaging	Het
Zfp341	G	A	2: 154,483,969 (GRCm39)	C586Y	possibly damaging	Het
Zfp687	G	A	3: 94,918,575 (GRCm39)	T399I	possibly damaging	Het
Zp1	G	T	19: 10,894,078 (GRCm39)		probably benign	Het
Zzz3	T	A	3: 152,157,720 (GRCm39)	D263E	probably benign	Het

Other mutations in Or5m9b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02370:Or5m9b	APN	2	85,905,132 (GRCm39)	missense	probably damaging	0.98
R0269:Or5m9b	UTSW	2	85,905,485 (GRCm39)	missense	probably benign	0.03
R0409:Or5m9b	UTSW	2	85,905,646 (GRCm39)	nonsense	probably null
R0412:Or5m9b	UTSW	2	85,905,435 (GRCm39)	missense	probably benign	0.16
R0617:Or5m9b	UTSW	2	85,905,485 (GRCm39)	missense	probably benign	0.03
R0846:Or5m9b	UTSW	2	85,905,510 (GRCm39)	missense	possibly damaging	0.66
R1251:Or5m9b	UTSW	2	85,905,164 (GRCm39)	missense	probably benign	0.20
R1646:Or5m9b	UTSW	2	85,905,960 (GRCm39)	missense	probably damaging	0.98
R1670:Or5m9b	UTSW	2	85,905,594 (GRCm39)	missense	probably benign
R1775:Or5m9b	UTSW	2	85,905,104 (GRCm39)	missense	possibly damaging	0.88
R1968:Or5m9b	UTSW	2	85,905,549 (GRCm39)	missense	probably damaging	1.00
R2877:Or5m9b	UTSW	2	85,905,675 (GRCm39)	missense	possibly damaging	0.82
R4639:Or5m9b	UTSW	2	85,905,923 (GRCm39)	missense	probably benign	0.24
R4957:Or5m9b	UTSW	2	85,905,854 (GRCm39)	missense	probably damaging	1.00
R5267:Or5m9b	UTSW	2	85,905,882 (GRCm39)	missense	probably benign	0.28
R5862:Or5m9b	UTSW	2	85,905,990 (GRCm39)	missense	probably benign	0.00
R6235:Or5m9b	UTSW	2	85,905,510 (GRCm39)	missense	possibly damaging	0.66
R6355:Or5m9b	UTSW	2	85,905,216 (GRCm39)	missense	probably benign	0.04
R6943:Or5m9b	UTSW	2	85,905,264 (GRCm39)	missense	probably damaging	1.00
R8033:Or5m9b	UTSW	2	85,905,219 (GRCm39)	missense	possibly damaging	0.61
R8796:Or5m9b	UTSW	2	85,905,518 (GRCm39)	missense	possibly damaging	0.94
R8861:Or5m9b	UTSW	2	85,905,960 (GRCm39)	missense	probably damaging	0.98
Z1088:Or5m9b	UTSW	2	85,905,667 (GRCm39)	missense	possibly damaging	0.66
Z1177:Or5m9b	UTSW	2	85,905,768 (GRCm39)	nonsense	probably null

Posted On

2015-04-16