Incidental Mutation 'IGL02260:Zfp341'
| ID |
286704 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp341
|
| Ensembl Gene |
ENSMUSG00000059842 |
| Gene Name |
zinc finger protein 341 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02260
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
154455217-154488741 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 154483969 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Tyrosine
at position 586
(C586Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105324
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000081926]
[ENSMUST00000109702]
[ENSMUST00000126421]
|
| AlphaFold |
Q6PGC9 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000081926
AA Change: C593Y
PolyPhen 2
Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000080596
Gene: ENSMUSG00000059842
AA Change: C593Y
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
53 |
73 |
4.16e1 |
SMART |
|
low complexity region
|
96 |
110 |
N/A |
INTRINSIC |
|
low complexity region
|
154 |
161 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
200 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
320 |
342 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
348 |
370 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
442 |
464 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
470 |
494 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
500 |
522 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
537 |
561 |
1.23e0 |
SMART |
|
ZnF_C2H2
|
563 |
585 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
591 |
613 |
1.62e0 |
SMART |
|
ZnF_C2H2
|
619 |
641 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
647 |
674 |
7.29e0 |
SMART |
|
ZnF_C2H2
|
680 |
702 |
5.14e-3 |
SMART |
|
low complexity region
|
740 |
759 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109702
AA Change: C586Y
PolyPhen 2
Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000105324
Gene: ENSMUSG00000059842
AA Change: C586Y
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
53 |
73 |
4.16e1 |
SMART |
|
low complexity region
|
96 |
110 |
N/A |
INTRINSIC |
|
low complexity region
|
154 |
161 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
200 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
313 |
335 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
341 |
363 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
463 |
487 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
493 |
515 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
530 |
554 |
1.23e0 |
SMART |
|
ZnF_C2H2
|
556 |
578 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
584 |
606 |
1.62e0 |
SMART |
|
ZnF_C2H2
|
612 |
634 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
640 |
667 |
7.29e0 |
SMART |
|
ZnF_C2H2
|
673 |
695 |
5.14e-3 |
SMART |
|
low complexity region
|
733 |
752 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000126421
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 43 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgre1 |
C |
T |
17: 57,754,891 (GRCm39) |
A663V |
probably benign |
Het |
| Atg2b |
A |
T |
12: 105,602,699 (GRCm39) |
|
probably benign |
Het |
| B4galt6 |
T |
C |
18: 20,833,804 (GRCm39) |
I194V |
probably benign |
Het |
| Caprin1 |
T |
C |
2: 103,609,714 (GRCm39) |
Y188C |
probably damaging |
Het |
| Ccdc85a |
A |
G |
11: 28,526,672 (GRCm39) |
F284S |
possibly damaging |
Het |
| Ccdc88b |
A |
T |
19: 6,832,717 (GRCm39) |
|
probably benign |
Het |
| Cox18 |
C |
T |
5: 90,365,384 (GRCm39) |
V272I |
possibly damaging |
Het |
| Dars1 |
A |
T |
1: 128,299,898 (GRCm39) |
M362K |
probably benign |
Het |
| Ddi1 |
A |
T |
9: 6,265,760 (GRCm39) |
M203K |
probably benign |
Het |
| Dlg4 |
G |
A |
11: 69,933,093 (GRCm39) |
G500R |
probably damaging |
Het |
| Ebf3 |
G |
A |
7: 136,807,919 (GRCm39) |
P375S |
probably damaging |
Het |
| Eif5b |
T |
A |
1: 38,084,537 (GRCm39) |
L842M |
possibly damaging |
Het |
| Fhdc1 |
G |
A |
3: 84,352,042 (GRCm39) |
A1061V |
possibly damaging |
Het |
| Gm5581 |
T |
C |
6: 131,144,909 (GRCm39) |
|
noncoding transcript |
Het |
| Mapk10 |
A |
T |
5: 103,186,534 (GRCm39) |
D29E |
probably benign |
Het |
| Mib2 |
C |
T |
4: 155,745,628 (GRCm39) |
R61H |
probably damaging |
Het |
| Mki67 |
A |
G |
7: 135,303,697 (GRCm39) |
S724P |
probably benign |
Het |
| Mtor |
T |
C |
4: 148,622,758 (GRCm39) |
I1946T |
probably damaging |
Het |
| Myh14 |
A |
G |
7: 44,260,995 (GRCm39) |
L1873P |
probably damaging |
Het |
| Myom1 |
C |
T |
17: 71,415,310 (GRCm39) |
Q1226* |
probably null |
Het |
| Neb |
A |
G |
2: 52,095,668 (GRCm39) |
L4858P |
probably damaging |
Het |
| Or51f5 |
A |
T |
7: 102,424,114 (GRCm39) |
I128F |
probably damaging |
Het |
| Or5m9b |
C |
A |
2: 85,905,816 (GRCm39) |
T244K |
possibly damaging |
Het |
| Or5p76 |
T |
C |
7: 108,122,492 (GRCm39) |
I222V |
probably benign |
Het |
| Pcdhb14 |
C |
T |
18: 37,583,086 (GRCm39) |
H731Y |
probably benign |
Het |
| Prdm16 |
T |
C |
4: 154,412,744 (GRCm39) |
N1087S |
probably benign |
Het |
| Prdm2 |
C |
T |
4: 142,861,157 (GRCm39) |
G711D |
probably damaging |
Het |
| Proser1 |
G |
A |
3: 53,386,365 (GRCm39) |
G749D |
probably damaging |
Het |
| Ptch1 |
A |
T |
13: 63,713,166 (GRCm39) |
|
probably benign |
Het |
| Pus10 |
A |
T |
11: 23,657,548 (GRCm39) |
K233* |
probably null |
Het |
| Rasa2 |
A |
G |
9: 96,426,372 (GRCm39) |
Y825H |
probably benign |
Het |
| Tbcd |
T |
C |
11: 121,494,104 (GRCm39) |
F969S |
probably damaging |
Het |
| Tbp |
T |
A |
17: 15,724,878 (GRCm39) |
S133T |
probably damaging |
Het |
| Tnks |
C |
T |
8: 35,310,137 (GRCm39) |
G1062D |
probably damaging |
Het |
| Tnrc6b |
T |
A |
15: 80,764,372 (GRCm39) |
S625T |
probably damaging |
Het |
| Triobp |
T |
C |
15: 78,850,562 (GRCm39) |
S239P |
probably benign |
Het |
| Ubiad1 |
T |
C |
4: 148,528,564 (GRCm39) |
D115G |
probably benign |
Het |
| Uckl1 |
A |
G |
2: 181,211,381 (GRCm39) |
S483P |
probably damaging |
Het |
| Vill |
A |
G |
9: 118,887,509 (GRCm39) |
D91G |
probably benign |
Het |
| Wdr62 |
C |
A |
7: 29,970,207 (GRCm39) |
C200F |
probably damaging |
Het |
| Zfp687 |
G |
A |
3: 94,918,575 (GRCm39) |
T399I |
possibly damaging |
Het |
| Zp1 |
G |
T |
19: 10,894,078 (GRCm39) |
|
probably benign |
Het |
| Zzz3 |
T |
A |
3: 152,157,720 (GRCm39) |
D263E |
probably benign |
Het |
|
| Other mutations in Zfp341 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00499:Zfp341
|
APN |
2 |
154,476,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01352:Zfp341
|
APN |
2 |
154,470,816 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01748:Zfp341
|
APN |
2 |
154,470,847 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02329:Zfp341
|
APN |
2 |
154,474,224 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
casanova_grimbacher
|
UTSW |
2 |
154,466,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Specious
|
UTSW |
2 |
154,488,054 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R0079:Zfp341
|
UTSW |
2 |
154,466,914 (GRCm39) |
nonsense |
probably null |
|
|
R0570:Zfp341
|
UTSW |
2 |
154,487,988 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0620:Zfp341
|
UTSW |
2 |
154,476,193 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1018:Zfp341
|
UTSW |
2 |
154,487,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1611:Zfp341
|
UTSW |
2 |
154,487,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1733:Zfp341
|
UTSW |
2 |
154,483,298 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1822:Zfp341
|
UTSW |
2 |
154,488,054 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1956:Zfp341
|
UTSW |
2 |
154,480,132 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2437:Zfp341
|
UTSW |
2 |
154,470,721 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3623:Zfp341
|
UTSW |
2 |
154,466,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4417:Zfp341
|
UTSW |
2 |
154,470,907 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4806:Zfp341
|
UTSW |
2 |
154,487,786 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4807:Zfp341
|
UTSW |
2 |
154,487,786 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4863:Zfp341
|
UTSW |
2 |
154,487,786 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4955:Zfp341
|
UTSW |
2 |
154,479,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4962:Zfp341
|
UTSW |
2 |
154,468,734 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5484:Zfp341
|
UTSW |
2 |
154,466,921 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5864:Zfp341
|
UTSW |
2 |
154,485,474 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5877:Zfp341
|
UTSW |
2 |
154,474,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5975:Zfp341
|
UTSW |
2 |
154,472,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5990:Zfp341
|
UTSW |
2 |
154,487,579 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6057:Zfp341
|
UTSW |
2 |
154,466,954 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6882:Zfp341
|
UTSW |
2 |
154,479,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7686:Zfp341
|
UTSW |
2 |
154,466,781 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7701:Zfp341
|
UTSW |
2 |
154,476,000 (GRCm39) |
splice site |
probably null |
|
|
R7847:Zfp341
|
UTSW |
2 |
154,476,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8109:Zfp341
|
UTSW |
2 |
154,469,820 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9313:Zfp341
|
UTSW |
2 |
154,469,907 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9484:Zfp341
|
UTSW |
2 |
154,485,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation