Incidental Mutation 'IGL02261:Ifit2'
ID |
286741 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Ifit2
|
Ensembl Gene |
ENSMUSG00000045932 |
Gene Name |
interferon-induced protein with tetratricopeptide repeats 2 |
Synonyms |
Ifi54 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.062)
|
Stock # |
IGL02261
|
Quality Score |
|
Status
|
|
Chromosome |
19 |
Chromosomal Location |
34528094-34553819 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 34551624 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Asparagine
at position 388
(I388N)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000099890
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102826]
[ENSMUST00000149829]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000102826
AA Change: I388N
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000099890 Gene: ENSMUSG00000045932 AA Change: I388N
Domain | Start | End | E-Value | Type |
Pfam:TPR_2
|
95 |
127 |
4e-4 |
PFAM |
Pfam:TPR_8
|
95 |
127 |
3.8e-4 |
PFAM |
Blast:TPR
|
138 |
171 |
7e-11 |
BLAST |
Blast:TPR
|
172 |
208 |
2e-9 |
BLAST |
low complexity region
|
211 |
222 |
N/A |
INTRINSIC |
Pfam:TPR_19
|
225 |
286 |
4e-8 |
PFAM |
low complexity region
|
396 |
406 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000149829
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susuceptibility to VSV infection with increased lethality and brain viral titer. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 40 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ambn |
G |
A |
5: 88,604,807 (GRCm39) |
V27M |
probably damaging |
Het |
Ank1 |
A |
G |
8: 23,578,015 (GRCm39) |
N222D |
probably damaging |
Het |
Bcas3 |
A |
T |
11: 85,422,756 (GRCm39) |
T542S |
probably damaging |
Het |
Btbd1 |
A |
T |
7: 81,455,507 (GRCm39) |
I288N |
probably damaging |
Het |
Ctps1 |
C |
T |
4: 120,399,776 (GRCm39) |
V500I |
possibly damaging |
Het |
Cul5 |
A |
C |
9: 53,546,337 (GRCm39) |
V345G |
probably damaging |
Het |
Dchs1 |
A |
G |
7: 105,421,776 (GRCm39) |
Y215H |
probably damaging |
Het |
Dmxl1 |
T |
A |
18: 49,973,566 (GRCm39) |
M67K |
possibly damaging |
Het |
Egln2 |
C |
T |
7: 26,859,291 (GRCm39) |
E353K |
possibly damaging |
Het |
Fbxw5 |
G |
T |
2: 25,393,746 (GRCm39) |
A325S |
probably benign |
Het |
Fhdc1 |
G |
A |
3: 84,352,042 (GRCm39) |
A1061V |
possibly damaging |
Het |
Gaa |
A |
G |
11: 119,172,091 (GRCm39) |
*207W |
probably null |
Het |
Herc2 |
A |
G |
7: 55,856,492 (GRCm39) |
T3947A |
probably damaging |
Het |
Ikzf4 |
T |
C |
10: 128,472,591 (GRCm39) |
T209A |
possibly damaging |
Het |
Il17re |
A |
T |
6: 113,445,472 (GRCm39) |
|
probably benign |
Het |
Insrr |
T |
A |
3: 87,708,029 (GRCm39) |
L157Q |
probably damaging |
Het |
Kcnq2 |
T |
G |
2: 180,723,483 (GRCm39) |
Y631S |
probably damaging |
Het |
Lrrfip1 |
A |
G |
1: 91,039,890 (GRCm39) |
I198V |
probably benign |
Het |
Mir7684 |
A |
T |
15: 82,273,345 (GRCm39) |
|
probably benign |
Het |
Mphosph9 |
C |
T |
5: 124,398,150 (GRCm39) |
E1049K |
probably damaging |
Het |
Mroh1 |
G |
A |
15: 76,313,360 (GRCm39) |
R611Q |
probably benign |
Het |
Mynn |
A |
T |
3: 30,661,280 (GRCm39) |
I121F |
possibly damaging |
Het |
Ndrg2 |
G |
A |
14: 52,148,566 (GRCm39) |
R32C |
probably damaging |
Het |
Or2ab1 |
T |
C |
11: 58,488,630 (GRCm39) |
I138T |
probably benign |
Het |
Or4p7 |
A |
G |
2: 88,221,725 (GRCm39) |
I45V |
probably benign |
Het |
Ppp1r9b |
A |
G |
11: 94,892,936 (GRCm39) |
E260G |
probably damaging |
Het |
Psd4 |
A |
G |
2: 24,291,756 (GRCm39) |
S652G |
probably damaging |
Het |
Psg25 |
C |
T |
7: 18,255,268 (GRCm39) |
R416H |
probably benign |
Het |
Pygm |
T |
A |
19: 6,438,301 (GRCm39) |
N171K |
probably damaging |
Het |
Rbm46 |
A |
T |
3: 82,771,723 (GRCm39) |
D297E |
possibly damaging |
Het |
Selenov |
T |
A |
7: 27,990,004 (GRCm39) |
T167S |
probably benign |
Het |
Serpina10 |
T |
C |
12: 103,583,208 (GRCm39) |
Y358C |
probably damaging |
Het |
Slc27a3 |
T |
C |
3: 90,295,002 (GRCm39) |
R352G |
probably benign |
Het |
Snx33 |
T |
C |
9: 56,833,862 (GRCm39) |
D69G |
probably benign |
Het |
St8sia2 |
G |
T |
7: 73,616,594 (GRCm39) |
P127H |
probably damaging |
Het |
Thbd |
T |
C |
2: 148,248,401 (GRCm39) |
K489R |
probably benign |
Het |
Ttn |
A |
T |
2: 76,767,049 (GRCm39) |
C3039S |
probably damaging |
Het |
Vmn1r167 |
T |
C |
7: 23,204,261 (GRCm39) |
M252V |
probably benign |
Het |
Xdh |
A |
G |
17: 74,220,960 (GRCm39) |
S590P |
possibly damaging |
Het |
Zfp827 |
G |
A |
8: 79,906,708 (GRCm39) |
V907I |
probably damaging |
Het |
|
Other mutations in Ifit2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01099:Ifit2
|
APN |
19 |
34,550,702 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02375:Ifit2
|
APN |
19 |
34,551,737 (GRCm39) |
missense |
probably benign |
0.01 |
Pushup
|
UTSW |
19 |
34,551,445 (GRCm39) |
missense |
probably benign |
0.38 |
R0017:Ifit2
|
UTSW |
19 |
34,550,973 (GRCm39) |
missense |
probably damaging |
1.00 |
R0017:Ifit2
|
UTSW |
19 |
34,550,973 (GRCm39) |
missense |
probably damaging |
1.00 |
R0682:Ifit2
|
UTSW |
19 |
34,551,012 (GRCm39) |
missense |
probably benign |
0.13 |
R0927:Ifit2
|
UTSW |
19 |
34,550,984 (GRCm39) |
missense |
probably benign |
0.03 |
R1462:Ifit2
|
UTSW |
19 |
34,550,586 (GRCm39) |
missense |
probably null |
0.12 |
R1462:Ifit2
|
UTSW |
19 |
34,550,586 (GRCm39) |
missense |
probably null |
0.12 |
R1526:Ifit2
|
UTSW |
19 |
34,550,602 (GRCm39) |
missense |
probably benign |
0.00 |
R2084:Ifit2
|
UTSW |
19 |
34,550,750 (GRCm39) |
missense |
probably damaging |
1.00 |
R3971:Ifit2
|
UTSW |
19 |
34,551,441 (GRCm39) |
missense |
probably benign |
0.00 |
R4008:Ifit2
|
UTSW |
19 |
34,551,445 (GRCm39) |
missense |
probably benign |
0.38 |
R4010:Ifit2
|
UTSW |
19 |
34,551,445 (GRCm39) |
missense |
probably benign |
0.38 |
R4011:Ifit2
|
UTSW |
19 |
34,551,445 (GRCm39) |
missense |
probably benign |
0.38 |
R4359:Ifit2
|
UTSW |
19 |
34,550,544 (GRCm39) |
missense |
possibly damaging |
0.85 |
R5179:Ifit2
|
UTSW |
19 |
34,550,976 (GRCm39) |
missense |
probably damaging |
1.00 |
R5240:Ifit2
|
UTSW |
19 |
34,551,796 (GRCm39) |
missense |
probably benign |
0.02 |
R5424:Ifit2
|
UTSW |
19 |
34,551,458 (GRCm39) |
missense |
probably benign |
0.19 |
R5528:Ifit2
|
UTSW |
19 |
34,550,937 (GRCm39) |
missense |
possibly damaging |
0.63 |
R6605:Ifit2
|
UTSW |
19 |
34,550,897 (GRCm39) |
nonsense |
probably null |
|
R7172:Ifit2
|
UTSW |
19 |
34,550,894 (GRCm39) |
missense |
probably benign |
0.24 |
R7424:Ifit2
|
UTSW |
19 |
34,550,598 (GRCm39) |
missense |
probably benign |
0.37 |
R8090:Ifit2
|
UTSW |
19 |
34,550,662 (GRCm39) |
missense |
possibly damaging |
0.70 |
R8356:Ifit2
|
UTSW |
19 |
34,550,908 (GRCm39) |
nonsense |
probably null |
|
R8553:Ifit2
|
UTSW |
19 |
34,550,538 (GRCm39) |
missense |
probably benign |
0.00 |
X0023:Ifit2
|
UTSW |
19 |
34,551,650 (GRCm39) |
missense |
possibly damaging |
0.59 |
X0064:Ifit2
|
UTSW |
19 |
34,551,323 (GRCm39) |
missense |
probably benign |
0.06 |
|
Posted On |
2015-04-16 |