Incidental Mutation 'IGL02261:Il17re'
ID 286773
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Il17re
Ensembl Gene ENSMUSG00000043088
Gene Name interleukin 17 receptor E
Synonyms Il25r
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02261
Quality Score
Status
Chromosome 6
Chromosomal Location 113435659-113447719 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to T at 113445472 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000053569] [ENSMUST00000058300] [ENSMUST00000058548] [ENSMUST00000101065] [ENSMUST00000203281] [ENSMUST00000203661] [ENSMUST00000204774]
AlphaFold Q8BH06
Predicted Effect probably benign
Transcript: ENSMUST00000053569
SMART Domains Protein: ENSMUSP00000054378
Gene: ENSMUSG00000043088

DomainStartEndE-ValueType
Pfam:IL17_R_N 1 207 8.2e-109 PFAM
transmembrane domain 214 236 N/A INTRINSIC
Pfam:SEFIR 247 384 8.5e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000058300
SMART Domains Protein: ENSMUSP00000055343
Gene: ENSMUSG00000030281

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:IL17_R_N 71 190 2.8e-45 PFAM
Pfam:IL17_R_N 189 432 1.3e-93 PFAM
transmembrane domain 441 460 N/A INTRINSIC
Pfam:SEFIR 473 623 7.7e-41 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000058548
SMART Domains Protein: ENSMUSP00000062103
Gene: ENSMUSG00000043088

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:IL17_R_N 26 408 6.2e-121 PFAM
transmembrane domain 415 437 N/A INTRINSIC
Pfam:SEFIR 448 585 1.3e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000101065
SMART Domains Protein: ENSMUSP00000098626
Gene: ENSMUSG00000043088

DomainStartEndE-ValueType
Pfam:IL17_R_N 1 207 8.2e-109 PFAM
transmembrane domain 214 236 N/A INTRINSIC
Pfam:SEFIR 247 384 8.5e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203281
SMART Domains Protein: ENSMUSP00000145363
Gene: ENSMUSG00000043088

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000203661
SMART Domains Protein: ENSMUSP00000145345
Gene: ENSMUSG00000043088

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:IL17_R_N 26 408 5.6e-121 PFAM
Pfam:SEFIR 403 539 1.6e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205211
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203897
Predicted Effect probably benign
Transcript: ENSMUST00000204774
SMART Domains Protein: ENSMUSP00000145384
Gene: ENSMUSG00000043088

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:IL17_R_N 26 408 5.6e-121 PFAM
low complexity region 417 426 N/A INTRINSIC
Pfam:SEFIR 428 565 1.2e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204447
Predicted Effect probably benign
Transcript: ENSMUST00000205208
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
PHENOTYPE: Homozygous mice exhibit increased susceptibility to DSS-induced colitis, imiquimod-induced psoriasis, and C. rodentium bacterial infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ambn G A 5: 88,604,807 (GRCm39) V27M probably damaging Het
Ank1 A G 8: 23,578,015 (GRCm39) N222D probably damaging Het
Bcas3 A T 11: 85,422,756 (GRCm39) T542S probably damaging Het
Btbd1 A T 7: 81,455,507 (GRCm39) I288N probably damaging Het
Ctps1 C T 4: 120,399,776 (GRCm39) V500I possibly damaging Het
Cul5 A C 9: 53,546,337 (GRCm39) V345G probably damaging Het
Dchs1 A G 7: 105,421,776 (GRCm39) Y215H probably damaging Het
Dmxl1 T A 18: 49,973,566 (GRCm39) M67K possibly damaging Het
Egln2 C T 7: 26,859,291 (GRCm39) E353K possibly damaging Het
Fbxw5 G T 2: 25,393,746 (GRCm39) A325S probably benign Het
Fhdc1 G A 3: 84,352,042 (GRCm39) A1061V possibly damaging Het
Gaa A G 11: 119,172,091 (GRCm39) *207W probably null Het
Herc2 A G 7: 55,856,492 (GRCm39) T3947A probably damaging Het
Ifit2 T A 19: 34,551,624 (GRCm39) I388N probably damaging Het
Ikzf4 T C 10: 128,472,591 (GRCm39) T209A possibly damaging Het
Insrr T A 3: 87,708,029 (GRCm39) L157Q probably damaging Het
Kcnq2 T G 2: 180,723,483 (GRCm39) Y631S probably damaging Het
Lrrfip1 A G 1: 91,039,890 (GRCm39) I198V probably benign Het
Mir7684 A T 15: 82,273,345 (GRCm39) probably benign Het
Mphosph9 C T 5: 124,398,150 (GRCm39) E1049K probably damaging Het
Mroh1 G A 15: 76,313,360 (GRCm39) R611Q probably benign Het
Mynn A T 3: 30,661,280 (GRCm39) I121F possibly damaging Het
Ndrg2 G A 14: 52,148,566 (GRCm39) R32C probably damaging Het
Or2ab1 T C 11: 58,488,630 (GRCm39) I138T probably benign Het
Or4p7 A G 2: 88,221,725 (GRCm39) I45V probably benign Het
Ppp1r9b A G 11: 94,892,936 (GRCm39) E260G probably damaging Het
Psd4 A G 2: 24,291,756 (GRCm39) S652G probably damaging Het
Psg25 C T 7: 18,255,268 (GRCm39) R416H probably benign Het
Pygm T A 19: 6,438,301 (GRCm39) N171K probably damaging Het
Rbm46 A T 3: 82,771,723 (GRCm39) D297E possibly damaging Het
Selenov T A 7: 27,990,004 (GRCm39) T167S probably benign Het
Serpina10 T C 12: 103,583,208 (GRCm39) Y358C probably damaging Het
Slc27a3 T C 3: 90,295,002 (GRCm39) R352G probably benign Het
Snx33 T C 9: 56,833,862 (GRCm39) D69G probably benign Het
St8sia2 G T 7: 73,616,594 (GRCm39) P127H probably damaging Het
Thbd T C 2: 148,248,401 (GRCm39) K489R probably benign Het
Ttn A T 2: 76,767,049 (GRCm39) C3039S probably damaging Het
Vmn1r167 T C 7: 23,204,261 (GRCm39) M252V probably benign Het
Xdh A G 17: 74,220,960 (GRCm39) S590P possibly damaging Het
Zfp827 G A 8: 79,906,708 (GRCm39) V907I probably damaging Het
Other mutations in Il17re
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00580:Il17re APN 6 113,446,560 (GRCm39) missense probably damaging 0.99
IGL01568:Il17re APN 6 113,447,013 (GRCm39) missense probably damaging 1.00
IGL01656:Il17re APN 6 113,439,934 (GRCm39) splice site probably benign
IGL01994:Il17re APN 6 113,445,411 (GRCm39) missense probably benign 0.13
IGL02699:Il17re APN 6 113,445,880 (GRCm39) missense probably damaging 1.00
PIT4382001:Il17re UTSW 6 113,446,038 (GRCm39) missense probably benign 0.00
R0195:Il17re UTSW 6 113,443,098 (GRCm39) missense probably damaging 1.00
R1901:Il17re UTSW 6 113,446,665 (GRCm39) missense probably damaging 0.98
R2232:Il17re UTSW 6 113,441,761 (GRCm39) missense probably damaging 1.00
R2357:Il17re UTSW 6 113,445,431 (GRCm39) missense possibly damaging 0.55
R2393:Il17re UTSW 6 113,439,314 (GRCm39) missense possibly damaging 0.91
R2916:Il17re UTSW 6 113,442,989 (GRCm39) critical splice donor site probably null
R4820:Il17re UTSW 6 113,442,816 (GRCm39) missense probably benign 0.08
R4951:Il17re UTSW 6 113,445,868 (GRCm39) missense probably damaging 1.00
R4974:Il17re UTSW 6 113,446,530 (GRCm39) missense probably benign 0.14
R5070:Il17re UTSW 6 113,435,971 (GRCm39) missense probably damaging 0.97
R5166:Il17re UTSW 6 113,439,923 (GRCm39) missense probably benign 0.00
R5404:Il17re UTSW 6 113,446,063 (GRCm39) missense probably benign 0.00
R5810:Il17re UTSW 6 113,446,557 (GRCm39) missense probably damaging 1.00
R5916:Il17re UTSW 6 113,447,084 (GRCm39) missense probably damaging 1.00
R6048:Il17re UTSW 6 113,447,069 (GRCm39) missense possibly damaging 0.95
R7432:Il17re UTSW 6 113,439,332 (GRCm39) missense probably benign 0.07
R7548:Il17re UTSW 6 113,443,348 (GRCm39) missense probably damaging 1.00
R7658:Il17re UTSW 6 113,435,943 (GRCm39) missense probably benign 0.23
R7716:Il17re UTSW 6 113,439,930 (GRCm39) critical splice donor site probably null
R7942:Il17re UTSW 6 113,443,111 (GRCm39) missense probably damaging 0.99
R8051:Il17re UTSW 6 113,436,328 (GRCm39) missense probably benign 0.01
R8090:Il17re UTSW 6 113,439,250 (GRCm39) nonsense probably null
R8302:Il17re UTSW 6 113,443,280 (GRCm39) nonsense probably null
R9299:Il17re UTSW 6 113,440,971 (GRCm39) missense probably benign 0.00
Z1177:Il17re UTSW 6 113,441,753 (GRCm39) missense possibly damaging 0.47
Posted On 2015-04-16