Incidental Mutation 'IGL02261:Il17re'
ID |
286773 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Il17re
|
Ensembl Gene |
ENSMUSG00000043088 |
Gene Name |
interleukin 17 receptor E |
Synonyms |
Il25r |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL02261
|
Quality Score |
|
Status
|
|
Chromosome |
6 |
Chromosomal Location |
113435659-113447719 bp(+) (GRCm39) |
Type of Mutation |
unclassified |
DNA Base Change (assembly) |
A to T
at 113445472 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053569]
[ENSMUST00000058300]
[ENSMUST00000058548]
[ENSMUST00000101065]
[ENSMUST00000203281]
[ENSMUST00000203661]
[ENSMUST00000204774]
|
AlphaFold |
Q8BH06 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000053569
|
SMART Domains |
Protein: ENSMUSP00000054378 Gene: ENSMUSG00000043088
Domain | Start | End | E-Value | Type |
Pfam:IL17_R_N
|
1 |
207 |
8.2e-109 |
PFAM |
transmembrane domain
|
214 |
236 |
N/A |
INTRINSIC |
Pfam:SEFIR
|
247 |
384 |
8.5e-29 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000058300
|
SMART Domains |
Protein: ENSMUSP00000055343 Gene: ENSMUSG00000030281
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Pfam:IL17_R_N
|
71 |
190 |
2.8e-45 |
PFAM |
Pfam:IL17_R_N
|
189 |
432 |
1.3e-93 |
PFAM |
transmembrane domain
|
441 |
460 |
N/A |
INTRINSIC |
Pfam:SEFIR
|
473 |
623 |
7.7e-41 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000058548
|
SMART Domains |
Protein: ENSMUSP00000062103 Gene: ENSMUSG00000043088
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
Pfam:IL17_R_N
|
26 |
408 |
6.2e-121 |
PFAM |
transmembrane domain
|
415 |
437 |
N/A |
INTRINSIC |
Pfam:SEFIR
|
448 |
585 |
1.3e-28 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000101065
|
SMART Domains |
Protein: ENSMUSP00000098626 Gene: ENSMUSG00000043088
Domain | Start | End | E-Value | Type |
Pfam:IL17_R_N
|
1 |
207 |
8.2e-109 |
PFAM |
transmembrane domain
|
214 |
236 |
N/A |
INTRINSIC |
Pfam:SEFIR
|
247 |
384 |
8.5e-29 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000203281
|
SMART Domains |
Protein: ENSMUSP00000145363 Gene: ENSMUSG00000043088
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000203661
|
SMART Domains |
Protein: ENSMUSP00000145345 Gene: ENSMUSG00000043088
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
Pfam:IL17_R_N
|
26 |
408 |
5.6e-121 |
PFAM |
Pfam:SEFIR
|
403 |
539 |
1.6e-25 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205211
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000203897
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000204774
|
SMART Domains |
Protein: ENSMUSP00000145384 Gene: ENSMUSG00000043088
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
Pfam:IL17_R_N
|
26 |
408 |
5.6e-121 |
PFAM |
low complexity region
|
417 |
426 |
N/A |
INTRINSIC |
Pfam:SEFIR
|
428 |
565 |
1.2e-28 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000204447
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000205208
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013] PHENOTYPE: Homozygous mice exhibit increased susceptibility to DSS-induced colitis, imiquimod-induced psoriasis, and C. rodentium bacterial infection. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 40 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ambn |
G |
A |
5: 88,604,807 (GRCm39) |
V27M |
probably damaging |
Het |
Ank1 |
A |
G |
8: 23,578,015 (GRCm39) |
N222D |
probably damaging |
Het |
Bcas3 |
A |
T |
11: 85,422,756 (GRCm39) |
T542S |
probably damaging |
Het |
Btbd1 |
A |
T |
7: 81,455,507 (GRCm39) |
I288N |
probably damaging |
Het |
Ctps1 |
C |
T |
4: 120,399,776 (GRCm39) |
V500I |
possibly damaging |
Het |
Cul5 |
A |
C |
9: 53,546,337 (GRCm39) |
V345G |
probably damaging |
Het |
Dchs1 |
A |
G |
7: 105,421,776 (GRCm39) |
Y215H |
probably damaging |
Het |
Dmxl1 |
T |
A |
18: 49,973,566 (GRCm39) |
M67K |
possibly damaging |
Het |
Egln2 |
C |
T |
7: 26,859,291 (GRCm39) |
E353K |
possibly damaging |
Het |
Fbxw5 |
G |
T |
2: 25,393,746 (GRCm39) |
A325S |
probably benign |
Het |
Fhdc1 |
G |
A |
3: 84,352,042 (GRCm39) |
A1061V |
possibly damaging |
Het |
Gaa |
A |
G |
11: 119,172,091 (GRCm39) |
*207W |
probably null |
Het |
Herc2 |
A |
G |
7: 55,856,492 (GRCm39) |
T3947A |
probably damaging |
Het |
Ifit2 |
T |
A |
19: 34,551,624 (GRCm39) |
I388N |
probably damaging |
Het |
Ikzf4 |
T |
C |
10: 128,472,591 (GRCm39) |
T209A |
possibly damaging |
Het |
Insrr |
T |
A |
3: 87,708,029 (GRCm39) |
L157Q |
probably damaging |
Het |
Kcnq2 |
T |
G |
2: 180,723,483 (GRCm39) |
Y631S |
probably damaging |
Het |
Lrrfip1 |
A |
G |
1: 91,039,890 (GRCm39) |
I198V |
probably benign |
Het |
Mir7684 |
A |
T |
15: 82,273,345 (GRCm39) |
|
probably benign |
Het |
Mphosph9 |
C |
T |
5: 124,398,150 (GRCm39) |
E1049K |
probably damaging |
Het |
Mroh1 |
G |
A |
15: 76,313,360 (GRCm39) |
R611Q |
probably benign |
Het |
Mynn |
A |
T |
3: 30,661,280 (GRCm39) |
I121F |
possibly damaging |
Het |
Ndrg2 |
G |
A |
14: 52,148,566 (GRCm39) |
R32C |
probably damaging |
Het |
Or2ab1 |
T |
C |
11: 58,488,630 (GRCm39) |
I138T |
probably benign |
Het |
Or4p7 |
A |
G |
2: 88,221,725 (GRCm39) |
I45V |
probably benign |
Het |
Ppp1r9b |
A |
G |
11: 94,892,936 (GRCm39) |
E260G |
probably damaging |
Het |
Psd4 |
A |
G |
2: 24,291,756 (GRCm39) |
S652G |
probably damaging |
Het |
Psg25 |
C |
T |
7: 18,255,268 (GRCm39) |
R416H |
probably benign |
Het |
Pygm |
T |
A |
19: 6,438,301 (GRCm39) |
N171K |
probably damaging |
Het |
Rbm46 |
A |
T |
3: 82,771,723 (GRCm39) |
D297E |
possibly damaging |
Het |
Selenov |
T |
A |
7: 27,990,004 (GRCm39) |
T167S |
probably benign |
Het |
Serpina10 |
T |
C |
12: 103,583,208 (GRCm39) |
Y358C |
probably damaging |
Het |
Slc27a3 |
T |
C |
3: 90,295,002 (GRCm39) |
R352G |
probably benign |
Het |
Snx33 |
T |
C |
9: 56,833,862 (GRCm39) |
D69G |
probably benign |
Het |
St8sia2 |
G |
T |
7: 73,616,594 (GRCm39) |
P127H |
probably damaging |
Het |
Thbd |
T |
C |
2: 148,248,401 (GRCm39) |
K489R |
probably benign |
Het |
Ttn |
A |
T |
2: 76,767,049 (GRCm39) |
C3039S |
probably damaging |
Het |
Vmn1r167 |
T |
C |
7: 23,204,261 (GRCm39) |
M252V |
probably benign |
Het |
Xdh |
A |
G |
17: 74,220,960 (GRCm39) |
S590P |
possibly damaging |
Het |
Zfp827 |
G |
A |
8: 79,906,708 (GRCm39) |
V907I |
probably damaging |
Het |
|
Other mutations in Il17re |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00580:Il17re
|
APN |
6 |
113,446,560 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01568:Il17re
|
APN |
6 |
113,447,013 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01656:Il17re
|
APN |
6 |
113,439,934 (GRCm39) |
splice site |
probably benign |
|
IGL01994:Il17re
|
APN |
6 |
113,445,411 (GRCm39) |
missense |
probably benign |
0.13 |
IGL02699:Il17re
|
APN |
6 |
113,445,880 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4382001:Il17re
|
UTSW |
6 |
113,446,038 (GRCm39) |
missense |
probably benign |
0.00 |
R0195:Il17re
|
UTSW |
6 |
113,443,098 (GRCm39) |
missense |
probably damaging |
1.00 |
R1901:Il17re
|
UTSW |
6 |
113,446,665 (GRCm39) |
missense |
probably damaging |
0.98 |
R2232:Il17re
|
UTSW |
6 |
113,441,761 (GRCm39) |
missense |
probably damaging |
1.00 |
R2357:Il17re
|
UTSW |
6 |
113,445,431 (GRCm39) |
missense |
possibly damaging |
0.55 |
R2393:Il17re
|
UTSW |
6 |
113,439,314 (GRCm39) |
missense |
possibly damaging |
0.91 |
R2916:Il17re
|
UTSW |
6 |
113,442,989 (GRCm39) |
critical splice donor site |
probably null |
|
R4820:Il17re
|
UTSW |
6 |
113,442,816 (GRCm39) |
missense |
probably benign |
0.08 |
R4951:Il17re
|
UTSW |
6 |
113,445,868 (GRCm39) |
missense |
probably damaging |
1.00 |
R4974:Il17re
|
UTSW |
6 |
113,446,530 (GRCm39) |
missense |
probably benign |
0.14 |
R5070:Il17re
|
UTSW |
6 |
113,435,971 (GRCm39) |
missense |
probably damaging |
0.97 |
R5166:Il17re
|
UTSW |
6 |
113,439,923 (GRCm39) |
missense |
probably benign |
0.00 |
R5404:Il17re
|
UTSW |
6 |
113,446,063 (GRCm39) |
missense |
probably benign |
0.00 |
R5810:Il17re
|
UTSW |
6 |
113,446,557 (GRCm39) |
missense |
probably damaging |
1.00 |
R5916:Il17re
|
UTSW |
6 |
113,447,084 (GRCm39) |
missense |
probably damaging |
1.00 |
R6048:Il17re
|
UTSW |
6 |
113,447,069 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7432:Il17re
|
UTSW |
6 |
113,439,332 (GRCm39) |
missense |
probably benign |
0.07 |
R7548:Il17re
|
UTSW |
6 |
113,443,348 (GRCm39) |
missense |
probably damaging |
1.00 |
R7658:Il17re
|
UTSW |
6 |
113,435,943 (GRCm39) |
missense |
probably benign |
0.23 |
R7716:Il17re
|
UTSW |
6 |
113,439,930 (GRCm39) |
critical splice donor site |
probably null |
|
R7942:Il17re
|
UTSW |
6 |
113,443,111 (GRCm39) |
missense |
probably damaging |
0.99 |
R8051:Il17re
|
UTSW |
6 |
113,436,328 (GRCm39) |
missense |
probably benign |
0.01 |
R8090:Il17re
|
UTSW |
6 |
113,439,250 (GRCm39) |
nonsense |
probably null |
|
R8302:Il17re
|
UTSW |
6 |
113,443,280 (GRCm39) |
nonsense |
probably null |
|
R9299:Il17re
|
UTSW |
6 |
113,440,971 (GRCm39) |
missense |
probably benign |
0.00 |
Z1177:Il17re
|
UTSW |
6 |
113,441,753 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
Posted On |
2015-04-16 |