Incidental Mutation 'IGL02264:Tmem169'
ID 286856
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem169
Ensembl Gene ENSMUSG00000026188
Gene Name transmembrane protein 169
Synonyms A830020B06Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # IGL02264
Quality Score
Status
Chromosome 1
Chromosomal Location 72323554-72342263 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 72340114 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 181 (Y181*)
Ref Sequence ENSEMBL: ENSMUSP00000027380 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027380] [ENSMUST00000141783]
AlphaFold Q8BG50
Predicted Effect probably null
Transcript: ENSMUST00000027380
AA Change: Y181*
SMART Domains Protein: ENSMUSP00000027380
Gene: ENSMUSG00000026188
AA Change: Y181*

DomainStartEndE-ValueType
low complexity region 21 31 N/A INTRINSIC
Pfam:TMEM169 147 277 6.1e-66 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000141783
SMART Domains Protein: ENSMUSP00000114990
Gene: ENSMUSG00000026188

DomainStartEndE-ValueType
low complexity region 21 31 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921504E06Rik A G 2: 19,547,180 (GRCm39) probably null Het
Abhd17b T C 19: 21,655,796 (GRCm39) L26P probably damaging Het
Abtb1 A G 6: 88,813,517 (GRCm39) V407A probably benign Het
Adamts17 C A 7: 66,697,207 (GRCm39) probably null Het
Arhgap21 G T 2: 20,864,850 (GRCm39) probably null Het
Brwd1 T C 16: 95,820,656 (GRCm39) D1290G probably damaging Het
Btbd6 A G 12: 112,940,589 (GRCm39) T49A probably damaging Het
Carmil1 C T 13: 24,259,699 (GRCm39) V702I possibly damaging Het
Cts8 T A 13: 61,398,772 (GRCm39) I245F probably damaging Het
Dclre1a T A 19: 56,532,725 (GRCm39) N623I possibly damaging Het
Dnah9 A T 11: 65,971,314 (GRCm39) probably benign Het
Emc1 T C 4: 139,102,775 (GRCm39) F978S probably damaging Het
Fam185a G A 5: 21,685,392 (GRCm39) V363I possibly damaging Het
Iglc2 G T 16: 19,017,397 (GRCm39) S69R probably damaging Het
Ints5 T C 19: 8,873,076 (GRCm39) V345A probably benign Het
Kif21b T A 1: 136,087,495 (GRCm39) L937Q probably damaging Het
Lrba A G 3: 86,687,569 (GRCm39) R2825G probably damaging Het
Map1a A G 2: 121,137,794 (GRCm39) E2870G probably damaging Het
Or4c125 G T 2: 89,170,028 (GRCm39) T206K probably benign Het
Or4k41 A G 2: 111,280,207 (GRCm39) T241A probably benign Het
Or5aq7 C T 2: 86,937,785 (GRCm39) probably benign Het
Or8b48 C T 9: 38,492,809 (GRCm39) P79S probably damaging Het
Pcsk1 C A 13: 75,254,078 (GRCm39) T210K probably damaging Het
Phaf1 C T 8: 105,961,178 (GRCm39) A71V possibly damaging Het
Slco5a1 A G 1: 12,942,219 (GRCm39) V809A probably benign Het
Synm T C 7: 67,384,144 (GRCm39) T1173A probably damaging Het
Tbc1d9b T C 11: 50,040,584 (GRCm39) I367T probably damaging Het
Trp73 G T 4: 154,148,885 (GRCm39) F289L probably null Het
Ttll9 A G 2: 152,842,055 (GRCm39) Y303C probably damaging Het
Ubr4 G T 4: 139,182,939 (GRCm39) E3577* probably null Het
Zbtb3 T G 19: 8,780,729 (GRCm39) V114G probably damaging Het
Other mutations in Tmem169
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01484:Tmem169 APN 1 72,340,263 (GRCm39) missense probably damaging 0.99
R1416:Tmem169 UTSW 1 72,339,875 (GRCm39) missense probably damaging 1.00
R1463:Tmem169 UTSW 1 72,339,855 (GRCm39) missense probably benign 0.19
R2138:Tmem169 UTSW 1 72,340,155 (GRCm39) missense probably damaging 1.00
R4810:Tmem169 UTSW 1 72,337,311 (GRCm39) missense probably benign 0.05
R4833:Tmem169 UTSW 1 72,337,311 (GRCm39) missense probably benign 0.05
R7166:Tmem169 UTSW 1 72,340,229 (GRCm39) missense probably benign
R8503:Tmem169 UTSW 1 72,340,166 (GRCm39) missense probably damaging 1.00
X0027:Tmem169 UTSW 1 72,337,086 (GRCm39) missense probably benign
Z1177:Tmem169 UTSW 1 72,340,289 (GRCm39) missense probably damaging 0.98
Posted On 2015-04-16