Incidental Mutation 'IGL02267:Vmn1r82'
ID286930
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r82
Ensembl Gene ENSMUSG00000058132
Gene Namevomeronasal 1 receptor 82
SynonymsV1rg12
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.063) question?
Stock #IGL02267
Quality Score
Status
Chromosome7
Chromosomal Location12300430-12308582 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 12305346 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 64 (Y64C)
Ref Sequence ENSEMBL: ENSMUSP00000154524 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072801] [ENSMUST00000191002] [ENSMUST00000227672]
Predicted Effect probably damaging
Transcript: ENSMUST00000072801
AA Change: Y181C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072580
Gene: ENSMUSG00000058132
AA Change: Y181C

DomainStartEndE-ValueType
Pfam:V1R 35 295 1.3e-28 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000191002
AA Change: Y182C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000140782
Gene: ENSMUSG00000058132
AA Change: Y182C

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:V1R 36 296 8.4e-27 PFAM
Pfam:7tm_1 39 290 2e-5 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000227672
AA Change: Y64C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts2 A G 11: 50,792,678 Q929R probably benign Het
Aplf A T 6: 87,658,964 D122E probably damaging Het
Atp2a3 T A 11: 72,987,984 L874Q probably damaging Het
Atp2b2 A T 6: 113,793,730 L406Q probably damaging Het
Atp6v1b1 A G 6: 83,756,909 D374G probably benign Het
Bcas1 T A 2: 170,378,788 R239* probably null Het
Bhmt2 A G 13: 93,669,346 V56A probably damaging Het
Cage1 T C 13: 38,023,257 E204G probably damaging Het
Ccdc157 G A 11: 4,144,035 A532V probably benign Het
Cd300lb G A 11: 114,928,477 R109* probably null Het
Clca4c-ps T C 3: 144,879,755 noncoding transcript Het
Ctnna3 G T 10: 64,945,998 V747F probably benign Het
Cyp2c29 A T 19: 39,330,422 I488F probably benign Het
Cyp3a25 T C 5: 145,998,552 M85V possibly damaging Het
Dnah7b T A 1: 46,226,930 Y2220N probably damaging Het
Espl1 A G 15: 102,315,664 I1217V probably benign Het
Exoc2 A G 13: 30,815,321 S918P probably benign Het
Fer1l4 T A 2: 156,031,252 I1303F possibly damaging Het
Gm28047 A T 15: 102,547,227 I234K probably damaging Het
Gm4951 T G 18: 60,246,398 V335G probably damaging Het
Gpcpd1 A G 2: 132,568,710 V19A probably damaging Het
Gprin3 A G 6: 59,354,473 V283A probably benign Het
Grb14 A G 2: 64,953,616 Y56H probably damaging Het
Greb1 A G 12: 16,717,208 F331S probably benign Het
Jkamp A G 12: 72,094,817 Y198C probably damaging Het
Klk1b11 G T 7: 43,999,741 C234F probably damaging Het
Nacad T C 11: 6,602,649 T181A probably benign Het
Olfr165 A T 16: 19,407,164 L285Q possibly damaging Het
Olfr382 A G 11: 73,516,549 S217P probably benign Het
Olfr987 T A 2: 85,331,121 Y259F probably damaging Het
Pitpnm3 A T 11: 72,071,448 I227N probably benign Het
Pnn A G 12: 59,070,209 E189G probably damaging Het
Pnpla2 C A 7: 141,458,209 P197T probably damaging Het
Pnpla6 A G 8: 3,517,327 T62A probably benign Het
Ptprq G T 10: 107,646,558 D1051E probably damaging Het
Rag2 C T 2: 101,630,031 R229C probably damaging Het
Serinc1 A T 10: 57,523,108 I196N probably damaging Het
Slc26a4 C T 12: 31,528,854 probably benign Het
Slc26a9 T C 1: 131,752,845 C43R probably damaging Het
Slc2a3 A T 6: 122,739,972 Y44N probably benign Het
Smad5 T G 13: 56,735,790 probably benign Het
Sugct C A 13: 17,644,865 V132F possibly damaging Het
Supt6 T C 11: 78,226,204 E568G possibly damaging Het
Tfpt T C 7: 3,628,983 T43A probably damaging Het
Timp4 A T 6: 115,247,279 V143E possibly damaging Het
Tns1 T C 1: 73,992,131 D275G possibly damaging Het
Trib1 A G 15: 59,651,600 E161G probably damaging Het
Trpc7 A T 13: 56,860,930 L308Q probably damaging Het
Ush1c A T 7: 46,209,298 V522E possibly damaging Het
Usp28 T C 9: 49,023,965 V449A probably damaging Het
Wwox G A 8: 114,712,065 M290I probably benign Het
Other mutations in Vmn1r82
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01509:Vmn1r82 APN 7 12305169 missense probably damaging 0.99
IGL01955:Vmn1r82 APN 7 12305723 unclassified probably null
R0336:Vmn1r82 UTSW 7 12305321 missense probably benign 0.26
R2373:Vmn1r82 UTSW 7 12305055 missense probably damaging 0.99
R2849:Vmn1r82 UTSW 7 12305406 missense probably damaging 1.00
R4621:Vmn1r82 UTSW 7 12305336 missense possibly damaging 0.71
R5628:Vmn1r82 UTSW 7 12305278 missense probably damaging 1.00
R6180:Vmn1r82 UTSW 7 12305085 missense probably damaging 0.97
R6263:Vmn1r82 UTSW 7 12305534 missense probably damaging 1.00
R6877:Vmn1r82 UTSW 7 12305363 missense possibly damaging 0.79
Posted On2015-04-16