Incidental Mutation 'IGL02267:Olfr165'
ID286948
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr165
Ensembl Gene ENSMUSG00000050158
Gene Nameolfactory receptor 165
SynonymsMOR279-1, GA_x54KRFPKG5P-15855164-15854223
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.068) question?
Stock #IGL02267
Quality Score
Status
Chromosome16
Chromosomal Location19406244-19423134 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 19407164 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Glutamine at position 285 (L285Q)
Ref Sequence ENSEMBL: ENSMUSP00000146100 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052516] [ENSMUST00000206110] [ENSMUST00000206410]
Predicted Effect possibly damaging
Transcript: ENSMUST00000052516
AA Change: L284Q

PolyPhen 2 Score 0.527 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000062079
Gene: ENSMUSG00000050158
AA Change: L284Q

DomainStartEndE-ValueType
Pfam:7tm_4 29 309 5.6e-48 PFAM
Pfam:7TM_GPCR_Srsx 36 306 6e-10 PFAM
Pfam:7tm_1 42 291 4e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000103984
Predicted Effect possibly damaging
Transcript: ENSMUST00000206110
AA Change: L284Q

PolyPhen 2 Score 0.527 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000206410
AA Change: L285Q

PolyPhen 2 Score 0.796 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts2 A G 11: 50,792,678 Q929R probably benign Het
Aplf A T 6: 87,658,964 D122E probably damaging Het
Atp2a3 T A 11: 72,987,984 L874Q probably damaging Het
Atp2b2 A T 6: 113,793,730 L406Q probably damaging Het
Atp6v1b1 A G 6: 83,756,909 D374G probably benign Het
Bcas1 T A 2: 170,378,788 R239* probably null Het
Bhmt2 A G 13: 93,669,346 V56A probably damaging Het
Cage1 T C 13: 38,023,257 E204G probably damaging Het
Ccdc157 G A 11: 4,144,035 A532V probably benign Het
Cd300lb G A 11: 114,928,477 R109* probably null Het
Clca4c-ps T C 3: 144,879,755 noncoding transcript Het
Ctnna3 G T 10: 64,945,998 V747F probably benign Het
Cyp2c29 A T 19: 39,330,422 I488F probably benign Het
Cyp3a25 T C 5: 145,998,552 M85V possibly damaging Het
Dnah7b T A 1: 46,226,930 Y2220N probably damaging Het
Espl1 A G 15: 102,315,664 I1217V probably benign Het
Exoc2 A G 13: 30,815,321 S918P probably benign Het
Fer1l4 T A 2: 156,031,252 I1303F possibly damaging Het
Gm28047 A T 15: 102,547,227 I234K probably damaging Het
Gm4951 T G 18: 60,246,398 V335G probably damaging Het
Gpcpd1 A G 2: 132,568,710 V19A probably damaging Het
Gprin3 A G 6: 59,354,473 V283A probably benign Het
Grb14 A G 2: 64,953,616 Y56H probably damaging Het
Greb1 A G 12: 16,717,208 F331S probably benign Het
Jkamp A G 12: 72,094,817 Y198C probably damaging Het
Klk1b11 G T 7: 43,999,741 C234F probably damaging Het
Nacad T C 11: 6,602,649 T181A probably benign Het
Olfr382 A G 11: 73,516,549 S217P probably benign Het
Olfr987 T A 2: 85,331,121 Y259F probably damaging Het
Pitpnm3 A T 11: 72,071,448 I227N probably benign Het
Pnn A G 12: 59,070,209 E189G probably damaging Het
Pnpla2 C A 7: 141,458,209 P197T probably damaging Het
Pnpla6 A G 8: 3,517,327 T62A probably benign Het
Ptprq G T 10: 107,646,558 D1051E probably damaging Het
Rag2 C T 2: 101,630,031 R229C probably damaging Het
Serinc1 A T 10: 57,523,108 I196N probably damaging Het
Slc26a4 C T 12: 31,528,854 probably benign Het
Slc26a9 T C 1: 131,752,845 C43R probably damaging Het
Slc2a3 A T 6: 122,739,972 Y44N probably benign Het
Smad5 T G 13: 56,735,790 probably benign Het
Sugct C A 13: 17,644,865 V132F possibly damaging Het
Supt6 T C 11: 78,226,204 E568G possibly damaging Het
Tfpt T C 7: 3,628,983 T43A probably damaging Het
Timp4 A T 6: 115,247,279 V143E possibly damaging Het
Tns1 T C 1: 73,992,131 D275G possibly damaging Het
Trib1 A G 15: 59,651,600 E161G probably damaging Het
Trpc7 A T 13: 56,860,930 L308Q probably damaging Het
Ush1c A T 7: 46,209,298 V522E possibly damaging Het
Usp28 T C 9: 49,023,965 V449A probably damaging Het
Vmn1r82 A G 7: 12,305,346 Y64C probably damaging Het
Wwox G A 8: 114,712,065 M290I probably benign Het
Other mutations in Olfr165
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01353:Olfr165 APN 16 19407583 missense probably benign 0.03
IGL01355:Olfr165 APN 16 19407583 missense probably benign 0.03
IGL01363:Olfr165 APN 16 19407583 missense probably benign 0.03
IGL01467:Olfr165 APN 16 19407789 missense probably benign 0.24
R1194:Olfr165 UTSW 16 19407180 missense possibly damaging 0.75
R1624:Olfr165 UTSW 16 19407704 missense probably benign 0.06
R2248:Olfr165 UTSW 16 19407194 missense probably damaging 0.98
R4865:Olfr165 UTSW 16 19407301 missense probably damaging 0.98
R4988:Olfr165 UTSW 16 19407110 missense probably benign 0.00
R5384:Olfr165 UTSW 16 19407797 missense probably damaging 1.00
R5858:Olfr165 UTSW 16 19407225 missense possibly damaging 0.91
R5997:Olfr165 UTSW 16 19407944 missense probably benign 0.10
R6301:Olfr165 UTSW 16 19407417 missense possibly damaging 0.96
R6570:Olfr165 UTSW 16 19407318 missense probably benign 0.00
R6703:Olfr165 UTSW 16 19407372 missense probably benign 0.03
R6953:Olfr165 UTSW 16 19407528 missense probably benign 0.04
R7424:Olfr165 UTSW 16 19407194 missense probably damaging 0.98
Z1176:Olfr165 UTSW 16 19407735 missense probably benign
Posted On2015-04-16