Incidental Mutation 'IGL02268:Or7e177'
ID 286980
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or7e177
Ensembl Gene ENSMUSG00000049028
Gene Name olfactory receptor family 7 subfamily E member 177
Synonyms Olfr873, GA_x6K02T2PVTD-14040245-14041204, MOR145-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # IGL02268
Quality Score
Status
Chromosome 9
Chromosomal Location 20211507-20212466 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 20211588 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 31 (S31P)
Ref Sequence ENSEMBL: ENSMUSP00000153816 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053919] [ENSMUST00000075717] [ENSMUST00000215540]
AlphaFold E9PX82
Predicted Effect probably damaging
Transcript: ENSMUST00000053919
AA Change: S28P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000054778
Gene: ENSMUSG00000049028
AA Change: S28P

DomainStartEndE-ValueType
Pfam:7tm_4 41 317 1.7e-52 PFAM
Pfam:7TM_GPCR_Srsx 45 315 1.6e-8 PFAM
Pfam:7tm_1 51 300 3e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000075717
AA Change: S32P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000075135
Gene: ENSMUSG00000049028
AA Change: S32P

DomainStartEndE-ValueType
Pfam:7tm_4 45 321 6.2e-43 PFAM
Pfam:7TM_GPCR_Srsx 49 309 3e-8 PFAM
Pfam:7tm_1 55 304 1.5e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212393
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212793
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213057
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213445
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216567
Predicted Effect probably damaging
Transcript: ENSMUST00000215540
AA Change: S31P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217193
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057J18Rik C T 10: 28,862,242 (GRCm39) C16Y probably benign Het
Abca13 C T 11: 9,240,626 (GRCm39) L830F probably benign Het
Apcdd1 T C 18: 63,083,259 (GRCm39) V363A probably damaging Het
Atosb T A 4: 43,036,468 (GRCm39) R88* probably null Het
Cachd1 A G 4: 100,809,294 (GRCm39) I260V possibly damaging Het
Cass4 T A 2: 172,268,962 (GRCm39) M350K possibly damaging Het
Ccnjl A G 11: 43,470,615 (GRCm39) T128A probably benign Het
Cd6 C T 19: 10,773,752 (GRCm39) G361D probably benign Het
Cdh22 T C 2: 164,965,639 (GRCm39) probably benign Het
Ces2h T A 8: 105,746,572 (GRCm39) F475Y probably benign Het
Col15a1 A T 4: 47,245,380 (GRCm39) T44S probably damaging Het
Cplx3 C T 9: 57,509,741 (GRCm39) E86K possibly damaging Het
Crbn A G 6: 106,772,004 (GRCm39) V100A possibly damaging Het
D430041D05Rik C A 2: 104,071,500 (GRCm39) V1267L possibly damaging Het
Ecrg4 T A 1: 43,770,111 (GRCm39) C23S probably damaging Het
Elapor1 C A 3: 108,375,113 (GRCm39) A585S probably benign Het
F930017D23Rik A G 10: 43,480,405 (GRCm39) noncoding transcript Het
Fastkd3 A G 13: 68,731,796 (GRCm39) D39G probably damaging Het
Golgb1 T A 16: 36,733,490 (GRCm39) S912R probably benign Het
H2-T24 T C 17: 36,328,264 (GRCm39) Y73C probably damaging Het
Ifna9 A T 4: 88,510,591 (GRCm39) L11* probably null Het
Igsf10 A T 3: 59,238,573 (GRCm39) L536* probably null Het
Itprid1 A T 6: 55,861,673 (GRCm39) probably benign Het
Kcnma1 A T 14: 23,593,144 (GRCm39) I215K probably damaging Het
Kdm4c A C 4: 74,291,953 (GRCm39) I857L possibly damaging Het
Kptn A T 7: 15,857,786 (GRCm39) H229L probably benign Het
Krt32 A T 11: 99,978,967 (GRCm39) M29K probably benign Het
Lama2 A G 10: 26,877,112 (GRCm39) probably benign Het
Lpcat2b A C 5: 107,581,982 (GRCm39) D437A probably damaging Het
Lrrc8c T C 5: 105,755,764 (GRCm39) L513P probably damaging Het
Mon1a T C 9: 107,778,997 (GRCm39) V407A possibly damaging Het
Myo5c C T 9: 75,153,519 (GRCm39) P135L probably damaging Het
Myof C T 19: 37,942,877 (GRCm39) V218M possibly damaging Het
Myof T A 19: 37,963,311 (GRCm39) I429F possibly damaging Het
Nbas A G 12: 13,455,398 (GRCm39) D1204G possibly damaging Het
Nckap1 G A 2: 80,358,962 (GRCm39) P560S probably benign Het
Notch2 G A 3: 98,044,713 (GRCm39) G1545D probably damaging Het
Ntrk1 G A 3: 87,688,838 (GRCm39) H572Y probably damaging Het
Or2t44 T C 11: 58,677,551 (GRCm39) F164L probably benign Het
Pate8 T C 9: 36,493,166 (GRCm39) Y52C possibly damaging Het
Pcdh15 A T 10: 74,178,504 (GRCm39) D587V probably damaging Het
Pik3cb T C 9: 98,928,609 (GRCm39) Y882C probably benign Het
Plch1 T A 3: 63,606,704 (GRCm39) *1074C probably null Het
Plcxd1 T C 5: 110,248,140 (GRCm39) probably benign Het
Ppp2r2d A G 7: 138,474,700 (GRCm39) N27S probably null Het
Prkar2a A G 9: 108,624,152 (GRCm39) M390V probably benign Het
Rab3gap1 A G 1: 127,796,695 (GRCm39) T18A probably damaging Het
Ranbp2 T C 10: 58,329,475 (GRCm39) probably benign Het
Rasl12 T C 9: 65,305,946 (GRCm39) S34P probably damaging Het
Rpusd3 A T 6: 113,395,818 (GRCm39) L65Q possibly damaging Het
Rtf2 A G 2: 172,310,639 (GRCm39) K290R probably damaging Het
Rwdd4a T A 8: 48,003,731 (GRCm39) L179* probably null Het
Scgb1b24 A G 7: 33,444,388 (GRCm39) E87G possibly damaging Het
Sgo2a A G 1: 58,056,881 (GRCm39) I1022V probably benign Het
Smg1 A C 7: 117,781,764 (GRCm39) I1174M probably benign Het
Spata17 A T 1: 186,872,595 (GRCm39) M72K probably damaging Het
Synpo2 G A 3: 122,910,632 (GRCm39) P338S probably damaging Het
Tpi1 G A 6: 124,791,087 (GRCm39) T50I probably benign Het
Trpm1 A G 7: 63,867,362 (GRCm39) E354G probably damaging Het
Uba2 A G 7: 33,842,161 (GRCm39) probably null Het
Wnk1 G A 6: 119,914,334 (GRCm39) R1823* probably null Het
Zfp248 A C 6: 118,430,801 (GRCm39) probably benign Het
Zfp51 A T 17: 21,683,681 (GRCm39) K99* probably null Het
Other mutations in Or7e177
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02122:Or7e177 APN 9 20,211,880 (GRCm39) missense probably damaging 1.00
IGL02416:Or7e177 APN 9 20,211,541 (GRCm39) missense probably benign 0.01
IGL03124:Or7e177 APN 9 20,212,459 (GRCm39) missense probably benign 0.00
R0147:Or7e177 UTSW 9 20,212,387 (GRCm39) missense probably damaging 1.00
R0148:Or7e177 UTSW 9 20,212,387 (GRCm39) missense probably damaging 1.00
R0266:Or7e177 UTSW 9 20,212,454 (GRCm39) missense probably benign 0.01
R0831:Or7e177 UTSW 9 20,211,861 (GRCm39) missense probably benign 0.20
R1456:Or7e177 UTSW 9 20,212,134 (GRCm39) missense probably benign 0.35
R1894:Or7e177 UTSW 9 20,211,633 (GRCm39) missense probably benign 0.23
R1928:Or7e177 UTSW 9 20,212,354 (GRCm39) missense probably benign 0.12
R2135:Or7e177 UTSW 9 20,211,593 (GRCm39) missense probably benign 0.00
R2379:Or7e177 UTSW 9 20,211,963 (GRCm39) missense possibly damaging 0.87
R2911:Or7e177 UTSW 9 20,211,775 (GRCm39) missense possibly damaging 0.60
R3788:Or7e177 UTSW 9 20,211,666 (GRCm39) missense probably benign 0.13
R4657:Or7e177 UTSW 9 20,211,919 (GRCm39) missense probably damaging 1.00
R5754:Or7e177 UTSW 9 20,212,390 (GRCm39) missense probably damaging 1.00
R6291:Or7e177 UTSW 9 20,211,899 (GRCm39) missense probably damaging 1.00
R6410:Or7e177 UTSW 9 20,211,748 (GRCm39) missense probably damaging 1.00
R7014:Or7e177 UTSW 9 20,211,959 (GRCm39) nonsense probably null
R7521:Or7e177 UTSW 9 20,212,036 (GRCm39) missense probably benign 0.00
R8201:Or7e177 UTSW 9 20,212,317 (GRCm39) missense probably damaging 1.00
R8355:Or7e177 UTSW 9 20,211,715 (GRCm39) missense probably damaging 1.00
R8455:Or7e177 UTSW 9 20,211,715 (GRCm39) missense probably damaging 1.00
R8523:Or7e177 UTSW 9 20,212,093 (GRCm39) missense probably benign 0.10
R8874:Or7e177 UTSW 9 20,212,069 (GRCm39) missense possibly damaging 0.95
R9283:Or7e177 UTSW 9 20,212,419 (GRCm39) missense possibly damaging 0.61
R9397:Or7e177 UTSW 9 20,211,748 (GRCm39) missense possibly damaging 0.50
R9595:Or7e177 UTSW 9 20,211,661 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16