Incidental Mutation 'IGL00905:Fam161b'
ID 28700
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fam161b
Ensembl Gene ENSMUSG00000021234
Gene Name family with sequence similarity 161, member B
Synonyms 9830169C18Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # IGL00905
Quality Score
Status
Chromosome 12
Chromosomal Location 84392083-84408607 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 84404459 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 74 (V74I)
Ref Sequence ENSEMBL: ENSMUSP00000070407 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021659] [ENSMUST00000021661] [ENSMUST00000065536] [ENSMUST00000110276] [ENSMUST00000110278] [ENSMUST00000152913]
AlphaFold Q8CB59
Predicted Effect probably benign
Transcript: ENSMUST00000021659
AA Change: V74I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000021659
Gene: ENSMUSG00000021234
AA Change: V74I

DomainStartEndE-ValueType
low complexity region 57 65 N/A INTRINSIC
low complexity region 93 107 N/A INTRINSIC
Pfam:UPF0564 168 535 5.3e-100 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000021661
SMART Domains Protein: ENSMUSP00000021661
Gene: ENSMUSG00000021235

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 46 56 N/A INTRINSIC
Pfam:FAD_binding_3 195 328 3.9e-8 PFAM
Pfam:FAD_binding_3 334 435 1.3e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000065536
AA Change: V74I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000070407
Gene: ENSMUSG00000021234
AA Change: V74I

DomainStartEndE-ValueType
low complexity region 57 65 N/A INTRINSIC
low complexity region 93 107 N/A INTRINSIC
Pfam:UPF0564 168 535 8.3e-112 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110276
SMART Domains Protein: ENSMUSP00000105905
Gene: ENSMUSG00000021235

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 46 56 N/A INTRINSIC
Pfam:FAD_binding_3 195 328 5.1e-8 PFAM
Pfam:FAD_binding_3 334 435 1.7e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110278
SMART Domains Protein: ENSMUSP00000105907
Gene: ENSMUSG00000021235

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 46 56 N/A INTRINSIC
Pfam:FAD_binding_3 195 328 6.8e-8 PFAM
Pfam:FAD_binding_3 334 410 1.1e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124257
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150391
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153450
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126752
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133230
Predicted Effect probably benign
Transcript: ENSMUST00000145522
SMART Domains Protein: ENSMUSP00000117609
Gene: ENSMUSG00000021235

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
SCOP:d1foha5 35 167 2e-6 SMART
PDB:4K22|B 90 156 3e-8 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000152913
SMART Domains Protein: ENSMUSP00000115676
Gene: ENSMUSG00000021235

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
SCOP:d1foha5 39 269 1e-10 SMART
PDB:4K22|B 94 274 1e-20 PDB
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atg16l2 T C 7: 100,949,373 (GRCm39) E58G probably damaging Het
D130040H23Rik A T 8: 69,753,422 (GRCm39) K16I possibly damaging Het
D630003M21Rik T C 2: 158,055,332 (GRCm39) T602A possibly damaging Het
Grk1 A G 8: 13,466,068 (GRCm39) E504G probably benign Het
Hnrnpm C A 17: 33,868,876 (GRCm39) R517L probably damaging Het
L3mbtl3 C T 10: 26,189,744 (GRCm39) probably null Het
Map1s A G 8: 71,358,673 (GRCm39) probably benign Het
Mprip T C 11: 59,662,994 (GRCm39) V982A possibly damaging Het
Or5aq1b A G 2: 86,901,563 (GRCm39) I305T probably benign Het
Or8g19 T G 9: 39,056,326 (GRCm39) F310C probably damaging Het
Phf1 A T 17: 27,155,568 (GRCm39) R378W possibly damaging Het
Pramel25 A G 4: 143,521,844 (GRCm39) T487A probably benign Het
Ptpn3 A T 4: 57,270,050 (GRCm39) D37E possibly damaging Het
Rcbtb1 A G 14: 59,465,754 (GRCm39) S366G probably benign Het
Scn5a C A 9: 119,365,567 (GRCm39) W360L probably damaging Het
Scrib A G 15: 75,936,839 (GRCm39) F398S probably damaging Het
Slc25a47 C A 12: 108,821,314 (GRCm39) T141K probably benign Het
Slc9a1 T A 4: 133,097,859 (GRCm39) M2K probably benign Het
Tango6 G T 8: 107,469,104 (GRCm39) probably null Het
Tmem231 A T 8: 112,645,072 (GRCm39) probably benign Het
Tnr G A 1: 159,679,752 (GRCm39) R242Q probably benign Het
Usp5 G A 6: 124,792,576 (GRCm39) P821S probably damaging Het
Utp11 G T 4: 124,577,586 (GRCm39) P63Q probably damaging Het
Vmn1r6 T A 6: 56,979,789 (GRCm39) N128K probably damaging Het
Other mutations in Fam161b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00540:Fam161b APN 12 84,408,525 (GRCm39) unclassified probably benign
IGL00900:Fam161b APN 12 84,402,743 (GRCm39) missense probably benign 0.05
IGL01123:Fam161b APN 12 84,404,438 (GRCm39) missense probably benign 0.00
IGL02156:Fam161b APN 12 84,401,527 (GRCm39) missense probably benign 0.00
IGL02630:Fam161b APN 12 84,400,688 (GRCm39) missense probably benign 0.03
IGL02670:Fam161b APN 12 84,404,368 (GRCm39) missense probably benign 0.00
IGL03160:Fam161b APN 12 84,400,599 (GRCm39) missense probably benign 0.05
R0560:Fam161b UTSW 12 84,404,492 (GRCm39) missense probably damaging 0.96
R0569:Fam161b UTSW 12 84,395,413 (GRCm39) missense probably damaging 1.00
R1834:Fam161b UTSW 12 84,395,552 (GRCm39) splice site probably benign
R2070:Fam161b UTSW 12 84,403,202 (GRCm39) missense probably benign 0.00
R3784:Fam161b UTSW 12 84,408,464 (GRCm39) critical splice donor site probably null
R3786:Fam161b UTSW 12 84,408,464 (GRCm39) critical splice donor site probably null
R4697:Fam161b UTSW 12 84,395,332 (GRCm39) unclassified probably benign
R5247:Fam161b UTSW 12 84,404,524 (GRCm39) missense probably damaging 1.00
R5390:Fam161b UTSW 12 84,395,408 (GRCm39) missense probably damaging 0.99
R5668:Fam161b UTSW 12 84,403,124 (GRCm39) missense probably damaging 0.96
R6891:Fam161b UTSW 12 84,401,554 (GRCm39) missense probably damaging 1.00
R7189:Fam161b UTSW 12 84,395,420 (GRCm39) missense probably damaging 1.00
R7410:Fam161b UTSW 12 84,404,575 (GRCm39) missense probably benign 0.04
R7514:Fam161b UTSW 12 84,404,512 (GRCm39) missense possibly damaging 0.76
R8035:Fam161b UTSW 12 84,395,430 (GRCm39) missense probably damaging 1.00
R8219:Fam161b UTSW 12 84,393,648 (GRCm39) missense probably benign 0.00
R8428:Fam161b UTSW 12 84,404,369 (GRCm39) missense probably benign 0.00
R8921:Fam161b UTSW 12 84,395,056 (GRCm39) missense probably benign 0.02
R9638:Fam161b UTSW 12 84,403,187 (GRCm39) missense probably benign 0.00
X0019:Fam161b UTSW 12 84,401,747 (GRCm39) missense probably benign 0.30
Z1176:Fam161b UTSW 12 84,402,827 (GRCm39) missense probably benign 0.00
Posted On 2013-04-17