Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02270:Vmn1r121'

287084

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r121

Ensembl Gene

ENSMUSG00000094680

Gene Name

vomeronasal 1 receptor 121

Synonyms

Gm8533

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

IGL02270

Quality Score

Status

Chromosome

Chromosomal Location

20831494-20832438 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20832401 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 13 (E13G)

Ref Sequence

ENSEMBL: ENSMUSP00000100832 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105197]

AlphaFold

K7N6J4

Predicted Effect

probably damaging
Transcript: ENSMUST00000105197
AA Change: E13G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000100832
Gene: ENSMUSG00000094680
AA Change: E13G

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	302	4.9e-18	PFAM
Pfam:7tm_1	31	278	1.6e-7	PFAM
Pfam:V1R	41	297	1.4e-17	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	T	C	13: 81,707,314 (GRCm39)		probably null	Het
Bmi1	T	A	2: 18,689,269 (GRCm39)	S318T	probably benign	Het
Cntnap5c	G	A	17: 58,341,848 (GRCm39)	V180I	probably benign	Het
Cyp2b10	A	G	7: 25,613,362 (GRCm39)	E186G	probably damaging	Het
Ddx25	G	T	9: 35,465,708 (GRCm39)		probably benign	Het
Dis3	A	G	14: 99,315,790 (GRCm39)	F901L	probably benign	Het
Dnah7a	T	A	1: 53,512,052 (GRCm39)	N3003I	possibly damaging	Het
Ebf2	A	G	14: 67,476,402 (GRCm39)	D124G	probably damaging	Het
Efcab5	A	T	11: 76,995,139 (GRCm39)	I1144N	probably damaging	Het
Exoc4	G	A	6: 33,556,961 (GRCm39)	V489I	possibly damaging	Het
Garem1	A	G	18: 21,281,507 (GRCm39)	V283A	probably damaging	Het
Gfra2	G	A	14: 71,163,347 (GRCm39)	R210H	possibly damaging	Het
Gli3	T	C	13: 15,901,371 (GRCm39)		probably benign	Het
Gm7247	A	T	14: 51,759,341 (GRCm39)	M107L	probably benign	Het
Map2k5	A	T	9: 63,229,479 (GRCm39)		probably null	Het
Mki67	C	T	7: 135,300,361 (GRCm39)	D1558N	probably damaging	Het
Mylk4	A	G	13: 32,913,049 (GRCm39)		probably benign	Het
Or14j9	G	T	17: 37,874,471 (GRCm39)	H244N	possibly damaging	Het
Or1e16	A	G	11: 73,286,191 (GRCm39)	V219A	probably benign	Het
Or52n5	A	G	7: 104,588,576 (GRCm39)	N281S	possibly damaging	Het
Or6a2	A	T	7: 106,600,630 (GRCm39)	C146S	probably damaging	Het
Plcd1	T	C	9: 118,913,709 (GRCm39)	T50A	probably damaging	Het
Rasgrp3	A	G	17: 75,823,368 (GRCm39)	R480G	probably benign	Het
Ripor3	T	C	2: 167,835,416 (GRCm39)	E185G	probably damaging	Het
S1pr3	T	C	13: 51,573,092 (GRCm39)	I91T	probably benign	Het
Slc26a4	C	T	12: 31,578,853 (GRCm39)		probably benign	Het
Slc28a3	T	C	13: 58,728,398 (GRCm39)	T104A	probably benign	Het
Slc6a11	A	G	6: 114,215,357 (GRCm39)	D419G	probably damaging	Het
St3gal2	A	G	8: 111,684,398 (GRCm39)	I19V	probably benign	Het
Sycp1	C	A	3: 102,803,259 (GRCm39)	C517F	probably benign	Het
Trav15-1-dv6-1	G	A	14: 53,797,455 (GRCm39)	E35K	possibly damaging	Het
Vmn1r199	T	A	13: 22,567,176 (GRCm39)	S114T	probably damaging	Het
Vmn2r129	T	C	4: 156,686,950 (GRCm39)		noncoding transcript	Het

Other mutations in Vmn1r121

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01636:Vmn1r121	APN	7	20,832,282 (GRCm39)	missense	probably benign	0.43
IGL02456:Vmn1r121	APN	7	20,832,438 (GRCm39)	start codon destroyed	possibly damaging	0.92
R0304:Vmn1r121	UTSW	7	20,832,332 (GRCm39)	missense	possibly damaging	0.91
R0336:Vmn1r121	UTSW	7	20,832,387 (GRCm39)	missense	possibly damaging	0.69
R3055:Vmn1r121	UTSW	7	20,832,390 (GRCm39)	nonsense	probably null
R4944:Vmn1r121	UTSW	7	20,831,538 (GRCm39)	missense	probably benign	0.00
R7443:Vmn1r121	UTSW	7	20,831,945 (GRCm39)	missense	probably damaging	1.00
R7492:Vmn1r121	UTSW	7	20,832,095 (GRCm39)	missense	probably damaging	1.00
R7575:Vmn1r121	UTSW	7	20,832,198 (GRCm39)	nonsense	probably null
R7723:Vmn1r121	UTSW	7	20,832,119 (GRCm39)	missense	probably damaging	1.00
R7914:Vmn1r121	UTSW	7	20,831,589 (GRCm39)	missense	probably benign	0.03
R8045:Vmn1r121	UTSW	7	20,831,829 (GRCm39)	missense	probably damaging	1.00
R8195:Vmn1r121	UTSW	7	20,832,228 (GRCm39)	missense	probably damaging	1.00
R8255:Vmn1r121	UTSW	7	20,831,679 (GRCm39)	missense	probably benign	0.19
R8256:Vmn1r121	UTSW	7	20,831,679 (GRCm39)	missense	probably benign	0.19
R9298:Vmn1r121	UTSW	7	20,832,344 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16