Incidental Mutation 'IGL02270:Vmn1r121'
ID287084
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r121
Ensembl Gene ENSMUSG00000094680
Gene Namevomeronasal 1 receptor 121
SynonymsGm8533
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.079) question?
Stock #IGL02270
Quality Score
Status
Chromosome7
Chromosomal Location21097569-21098513 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 21098476 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 13 (E13G)
Ref Sequence ENSEMBL: ENSMUSP00000100832 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105197]
Predicted Effect probably damaging
Transcript: ENSMUST00000105197
AA Change: E13G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000100832
Gene: ENSMUSG00000094680
AA Change: E13G

DomainStartEndE-ValueType
Pfam:TAS2R 8 302 4.9e-18 PFAM
Pfam:7tm_1 31 278 1.6e-7 PFAM
Pfam:V1R 41 297 1.4e-17 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 T C 13: 81,559,195 probably null Het
Bmi1 T A 2: 18,684,458 S318T probably benign Het
Cntnap5c G A 17: 58,034,853 V180I probably benign Het
Cyp2b10 A G 7: 25,913,937 E186G probably damaging Het
Ddx25 G T 9: 35,554,412 probably benign Het
Dis3 A G 14: 99,078,354 F901L probably benign Het
Dnah7a T A 1: 53,472,893 N3003I possibly damaging Het
Ebf2 A G 14: 67,238,953 D124G probably damaging Het
Efcab5 A T 11: 77,104,313 I1144N probably damaging Het
Exoc4 G A 6: 33,580,026 V489I possibly damaging Het
Garem1 A G 18: 21,148,450 V283A probably damaging Het
Gfra2 G A 14: 70,925,907 R210H possibly damaging Het
Gli3 T C 13: 15,726,786 probably benign Het
Gm7247 A T 14: 51,521,884 M107L probably benign Het
Map2k5 A T 9: 63,322,197 probably null Het
Mki67 C T 7: 135,698,632 D1558N probably damaging Het
Mylk4 A G 13: 32,729,066 probably benign Het
Olfr1 A G 11: 73,395,365 V219A probably benign Het
Olfr112 G T 17: 37,563,580 H244N possibly damaging Het
Olfr2 A T 7: 107,001,423 C146S probably damaging Het
Olfr669 A G 7: 104,939,369 N281S possibly damaging Het
Plcd1 T C 9: 119,084,641 T50A probably damaging Het
Rasgrp3 A G 17: 75,516,373 R480G probably benign Het
Ripor3 T C 2: 167,993,496 E185G probably damaging Het
S1pr3 T C 13: 51,419,056 I91T probably benign Het
Slc26a4 C T 12: 31,528,854 probably benign Het
Slc28a3 T C 13: 58,580,584 T104A probably benign Het
Slc6a11 A G 6: 114,238,396 D419G probably damaging Het
St3gal2 A G 8: 110,957,766 I19V probably benign Het
Sycp1 C A 3: 102,895,943 C517F probably benign Het
Trav15-1-dv6-1 G A 14: 53,559,998 E35K possibly damaging Het
Vmn1r199 T A 13: 22,383,006 S114T probably damaging Het
Vmn2r-ps159 T C 4: 156,334,655 noncoding transcript Het
Other mutations in Vmn1r121
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01636:Vmn1r121 APN 7 21098357 missense probably benign 0.43
IGL02456:Vmn1r121 APN 7 21098513 start codon destroyed possibly damaging 0.92
R0304:Vmn1r121 UTSW 7 21098407 missense possibly damaging 0.91
R0336:Vmn1r121 UTSW 7 21098462 missense possibly damaging 0.69
R3055:Vmn1r121 UTSW 7 21098465 nonsense probably null
R4944:Vmn1r121 UTSW 7 21097613 missense probably benign 0.00
R7443:Vmn1r121 UTSW 7 21098020 missense probably damaging 1.00
R7492:Vmn1r121 UTSW 7 21098170 missense probably damaging 1.00
Posted On2015-04-16