Incidental Mutation 'IGL02270:Vmn1r199'
ID287085
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r199
Ensembl Gene ENSMUSG00000069292
Gene Namevomeronasal 1 receptor 199
SynonymsV1rh4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.085) question?
Stock #IGL02270
Quality Score
Status
Chromosome13
Chromosomal Location22379818-22388102 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 22383006 bp
ZygosityHeterozygous
Amino Acid Change Serine to Threonine at position 114 (S114T)
Ref Sequence ENSEMBL: ENSMUSP00000153996 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091732] [ENSMUST00000227685] [ENSMUST00000227689] [ENSMUST00000227846]
Predicted Effect probably damaging
Transcript: ENSMUST00000091732
AA Change: S157T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000089326
Gene: ENSMUSG00000069292
AA Change: S157T

DomainStartEndE-ValueType
low complexity region 26 37 N/A INTRINSIC
Pfam:TAS2R 43 338 3.3e-7 PFAM
Pfam:V1R 75 340 1.6e-33 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120663
Predicted Effect probably damaging
Transcript: ENSMUST00000227685
AA Change: S157T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227689
AA Change: S114T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227846
AA Change: S114T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 T C 13: 81,559,195 probably null Het
Bmi1 T A 2: 18,684,458 S318T probably benign Het
Cntnap5c G A 17: 58,034,853 V180I probably benign Het
Cyp2b10 A G 7: 25,913,937 E186G probably damaging Het
Ddx25 G T 9: 35,554,412 probably benign Het
Dis3 A G 14: 99,078,354 F901L probably benign Het
Dnah7a T A 1: 53,472,893 N3003I possibly damaging Het
Ebf2 A G 14: 67,238,953 D124G probably damaging Het
Efcab5 A T 11: 77,104,313 I1144N probably damaging Het
Exoc4 G A 6: 33,580,026 V489I possibly damaging Het
Garem1 A G 18: 21,148,450 V283A probably damaging Het
Gfra2 G A 14: 70,925,907 R210H possibly damaging Het
Gli3 T C 13: 15,726,786 probably benign Het
Gm7247 A T 14: 51,521,884 M107L probably benign Het
Map2k5 A T 9: 63,322,197 probably null Het
Mki67 C T 7: 135,698,632 D1558N probably damaging Het
Mylk4 A G 13: 32,729,066 probably benign Het
Olfr1 A G 11: 73,395,365 V219A probably benign Het
Olfr112 G T 17: 37,563,580 H244N possibly damaging Het
Olfr2 A T 7: 107,001,423 C146S probably damaging Het
Olfr669 A G 7: 104,939,369 N281S possibly damaging Het
Plcd1 T C 9: 119,084,641 T50A probably damaging Het
Rasgrp3 A G 17: 75,516,373 R480G probably benign Het
Ripor3 T C 2: 167,993,496 E185G probably damaging Het
S1pr3 T C 13: 51,419,056 I91T probably benign Het
Slc26a4 C T 12: 31,528,854 probably benign Het
Slc28a3 T C 13: 58,580,584 T104A probably benign Het
Slc6a11 A G 6: 114,238,396 D419G probably damaging Het
St3gal2 A G 8: 110,957,766 I19V probably benign Het
Sycp1 C A 3: 102,895,943 C517F probably benign Het
Trav15-1-dv6-1 G A 14: 53,559,998 E35K possibly damaging Het
Vmn1r121 T C 7: 21,098,476 E13G probably damaging Het
Vmn2r-ps159 T C 4: 156,334,655 noncoding transcript Het
Other mutations in Vmn1r199
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00930:Vmn1r199 APN 13 22382859 missense possibly damaging 0.64
IGL01959:Vmn1r199 APN 13 22383120 missense probably benign 0.07
IGL02687:Vmn1r199 APN 13 22382791 missense possibly damaging 0.91
IGL03143:Vmn1r199 APN 13 22383129 missense probably damaging 1.00
R0528:Vmn1r199 UTSW 13 22382566 missense probably benign
R1411:Vmn1r199 UTSW 13 22383501 missense probably benign 0.01
R2075:Vmn1r199 UTSW 13 22383265 missense probably damaging 1.00
R5057:Vmn1r199 UTSW 13 22383405 missense possibly damaging 0.93
R5824:Vmn1r199 UTSW 13 22383578 missense probably benign
R5977:Vmn1r199 UTSW 13 22383246 missense probably benign 0.08
R6019:Vmn1r199 UTSW 13 22382599 missense possibly damaging 0.85
R6419:Vmn1r199 UTSW 13 22383607 missense possibly damaging 0.66
R7624:Vmn1r199 UTSW 13 22382736 missense probably benign 0.00
R7637:Vmn1r199 UTSW 13 22382675 missense probably benign 0.05
Posted On2015-04-16