Incidental Mutation 'IGL02270:Vmn1r199'
ID 287085
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r199
Ensembl Gene ENSMUSG00000069292
Gene Name vomeronasal 1 receptor 199
Synonyms V1rh4
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # IGL02270
Quality Score
Status
Chromosome 13
Chromosomal Location 22566708-22567811 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 22567176 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 114 (S114T)
Ref Sequence ENSEMBL: ENSMUSP00000153996 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091732] [ENSMUST00000227685] [ENSMUST00000227689] [ENSMUST00000227846]
AlphaFold Q8R280
Predicted Effect probably damaging
Transcript: ENSMUST00000091732
AA Change: S157T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000089326
Gene: ENSMUSG00000069292
AA Change: S157T

DomainStartEndE-ValueType
low complexity region 26 37 N/A INTRINSIC
Pfam:TAS2R 43 338 3.3e-7 PFAM
Pfam:V1R 75 340 1.6e-33 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120663
Predicted Effect probably damaging
Transcript: ENSMUST00000227685
AA Change: S157T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227689
AA Change: S114T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227846
AA Change: S114T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 T C 13: 81,707,314 (GRCm39) probably null Het
Bmi1 T A 2: 18,689,269 (GRCm39) S318T probably benign Het
Cntnap5c G A 17: 58,341,848 (GRCm39) V180I probably benign Het
Cyp2b10 A G 7: 25,613,362 (GRCm39) E186G probably damaging Het
Ddx25 G T 9: 35,465,708 (GRCm39) probably benign Het
Dis3 A G 14: 99,315,790 (GRCm39) F901L probably benign Het
Dnah7a T A 1: 53,512,052 (GRCm39) N3003I possibly damaging Het
Ebf2 A G 14: 67,476,402 (GRCm39) D124G probably damaging Het
Efcab5 A T 11: 76,995,139 (GRCm39) I1144N probably damaging Het
Exoc4 G A 6: 33,556,961 (GRCm39) V489I possibly damaging Het
Garem1 A G 18: 21,281,507 (GRCm39) V283A probably damaging Het
Gfra2 G A 14: 71,163,347 (GRCm39) R210H possibly damaging Het
Gli3 T C 13: 15,901,371 (GRCm39) probably benign Het
Gm7247 A T 14: 51,759,341 (GRCm39) M107L probably benign Het
Map2k5 A T 9: 63,229,479 (GRCm39) probably null Het
Mki67 C T 7: 135,300,361 (GRCm39) D1558N probably damaging Het
Mylk4 A G 13: 32,913,049 (GRCm39) probably benign Het
Or14j9 G T 17: 37,874,471 (GRCm39) H244N possibly damaging Het
Or1e16 A G 11: 73,286,191 (GRCm39) V219A probably benign Het
Or52n5 A G 7: 104,588,576 (GRCm39) N281S possibly damaging Het
Or6a2 A T 7: 106,600,630 (GRCm39) C146S probably damaging Het
Plcd1 T C 9: 118,913,709 (GRCm39) T50A probably damaging Het
Rasgrp3 A G 17: 75,823,368 (GRCm39) R480G probably benign Het
Ripor3 T C 2: 167,835,416 (GRCm39) E185G probably damaging Het
S1pr3 T C 13: 51,573,092 (GRCm39) I91T probably benign Het
Slc26a4 C T 12: 31,578,853 (GRCm39) probably benign Het
Slc28a3 T C 13: 58,728,398 (GRCm39) T104A probably benign Het
Slc6a11 A G 6: 114,215,357 (GRCm39) D419G probably damaging Het
St3gal2 A G 8: 111,684,398 (GRCm39) I19V probably benign Het
Sycp1 C A 3: 102,803,259 (GRCm39) C517F probably benign Het
Trav15-1-dv6-1 G A 14: 53,797,455 (GRCm39) E35K possibly damaging Het
Vmn1r121 T C 7: 20,832,401 (GRCm39) E13G probably damaging Het
Vmn2r129 T C 4: 156,686,950 (GRCm39) noncoding transcript Het
Other mutations in Vmn1r199
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00930:Vmn1r199 APN 13 22,567,029 (GRCm39) missense possibly damaging 0.64
IGL01959:Vmn1r199 APN 13 22,567,290 (GRCm39) missense probably benign 0.07
IGL02687:Vmn1r199 APN 13 22,566,961 (GRCm39) missense possibly damaging 0.91
IGL03143:Vmn1r199 APN 13 22,567,299 (GRCm39) missense probably damaging 1.00
R0528:Vmn1r199 UTSW 13 22,566,736 (GRCm39) missense probably benign
R1411:Vmn1r199 UTSW 13 22,567,671 (GRCm39) missense probably benign 0.01
R2075:Vmn1r199 UTSW 13 22,567,435 (GRCm39) missense probably damaging 1.00
R5057:Vmn1r199 UTSW 13 22,567,575 (GRCm39) missense possibly damaging 0.93
R5824:Vmn1r199 UTSW 13 22,567,748 (GRCm39) missense probably benign
R5977:Vmn1r199 UTSW 13 22,567,416 (GRCm39) missense probably benign 0.08
R6019:Vmn1r199 UTSW 13 22,566,769 (GRCm39) missense possibly damaging 0.85
R6419:Vmn1r199 UTSW 13 22,567,777 (GRCm39) missense possibly damaging 0.66
R7624:Vmn1r199 UTSW 13 22,566,906 (GRCm39) missense probably benign 0.00
R7637:Vmn1r199 UTSW 13 22,566,845 (GRCm39) missense probably benign 0.05
R8505:Vmn1r199 UTSW 13 22,567,317 (GRCm39) missense probably benign 0.01
R8692:Vmn1r199 UTSW 13 22,567,809 (GRCm39) makesense probably null
R8735:Vmn1r199 UTSW 13 22,567,537 (GRCm39) missense probably damaging 1.00
R8791:Vmn1r199 UTSW 13 22,567,687 (GRCm39) missense probably damaging 1.00
R9054:Vmn1r199 UTSW 13 22,567,724 (GRCm39) missense possibly damaging 0.95
R9258:Vmn1r199 UTSW 13 22,566,822 (GRCm39) missense possibly damaging 0.53
R9586:Vmn1r199 UTSW 13 22,567,716 (GRCm39) missense probably benign
Posted On 2015-04-16