Incidental Mutation 'IGL00910:Serpina6'
ID 28711
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Serpina6
Ensembl Gene ENSMUSG00000060807
Gene Name serine (or cysteine) peptidase inhibitor, clade A, member 6
Synonyms Cbg
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # IGL00910
Quality Score
Status
Chromosome 12
Chromosomal Location 103612889-103623471 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to T at 103618224 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000119290 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044159] [ENSMUST00000152517]
AlphaFold Q06770
Predicted Effect probably benign
Transcript: ENSMUST00000044159
SMART Domains Protein: ENSMUSP00000044033
Gene: ENSMUSG00000060807

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
SERPIN 43 396 3.45e-160 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000152517
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a protein that belongs to the serpin (serine protease inhibitor) family. The encoded protein is an alpha-globulin with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors. [provided by RefSeq, Sep 2015]
PHENOTYPE: Null homozygotes exhibit reduced total plasma corticosterone, increased susceptibility to bacterial infection, attenuation of the stress-induced surge in free corticosterone, and enhanced behavioral response to intense or uncontrollable stress. They exhibit no locomotor sensitization to cocaine. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5031439G07Rik A G 15: 84,840,020 (GRCm39) L109P probably damaging Het
Aacs T A 5: 125,585,772 (GRCm39) M316K probably benign Het
Adarb2 T C 13: 8,722,469 (GRCm39) V375A probably damaging Het
Adgra2 C A 8: 27,576,011 (GRCm39) A13E possibly damaging Het
Ankrd34c A T 9: 89,611,079 (GRCm39) S421T probably benign Het
Bpifa6 A T 2: 153,832,386 (GRCm39) M298L probably benign Het
Casq2 T C 3: 102,017,547 (GRCm39) probably benign Het
Ckap5 A G 2: 91,406,395 (GRCm39) T762A probably benign Het
Dhx38 A G 8: 110,285,666 (GRCm39) V389A probably benign Het
Dnah7b A T 1: 46,105,889 (GRCm39) probably benign Het
Dnajc7 A T 11: 100,490,017 (GRCm39) F79L possibly damaging Het
Dyrk3 A G 1: 131,064,073 (GRCm39) I3T possibly damaging Het
Fchsd2 T C 7: 100,926,833 (GRCm39) I641T probably benign Het
Furin A G 7: 80,040,744 (GRCm39) V698A probably benign Het
Lratd1 T C 12: 14,200,527 (GRCm39) S67G probably benign Het
Prl2c5 G A 13: 13,364,061 (GRCm39) probably null Het
Ryr3 A T 2: 112,559,279 (GRCm39) probably benign Het
Slc6a2 A G 8: 93,722,728 (GRCm39) Y575C probably damaging Het
Trim9 T C 12: 70,393,887 (GRCm39) E19G probably damaging Het
Tsfm G T 10: 126,864,228 (GRCm39) probably benign Het
Other mutations in Serpina6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00423:Serpina6 APN 12 103,618,162 (GRCm39) missense probably damaging 1.00
IGL01512:Serpina6 APN 12 103,620,318 (GRCm39) missense probably damaging 0.96
IGL02994:Serpina6 APN 12 103,620,210 (GRCm39) missense probably benign 0.03
IGL03092:Serpina6 APN 12 103,620,154 (GRCm39) critical splice donor site probably null
IGL03351:Serpina6 APN 12 103,613,172 (GRCm39) missense probably damaging 1.00
R0178:Serpina6 UTSW 12 103,613,172 (GRCm39) missense probably damaging 0.98
R0362:Serpina6 UTSW 12 103,618,208 (GRCm39) missense probably damaging 0.98
R0530:Serpina6 UTSW 12 103,618,053 (GRCm39) missense probably damaging 1.00
R1542:Serpina6 UTSW 12 103,620,732 (GRCm39) missense probably benign 0.09
R1573:Serpina6 UTSW 12 103,618,012 (GRCm39) missense probably damaging 1.00
R1764:Serpina6 UTSW 12 103,620,182 (GRCm39) missense probably damaging 1.00
R2243:Serpina6 UTSW 12 103,613,187 (GRCm39) missense probably benign 0.00
R2309:Serpina6 UTSW 12 103,620,438 (GRCm39) missense probably benign 0.00
R2363:Serpina6 UTSW 12 103,614,868 (GRCm39) missense probably benign 0.00
R3691:Serpina6 UTSW 12 103,620,668 (GRCm39) missense probably benign 0.00
R4492:Serpina6 UTSW 12 103,613,146 (GRCm39) missense probably damaging 1.00
R4498:Serpina6 UTSW 12 103,620,326 (GRCm39) missense probably benign 0.02
R4953:Serpina6 UTSW 12 103,618,221 (GRCm39) critical splice acceptor site probably null
R4985:Serpina6 UTSW 12 103,620,195 (GRCm39) missense probably benign 0.00
R5022:Serpina6 UTSW 12 103,617,971 (GRCm39) missense probably damaging 1.00
R5230:Serpina6 UTSW 12 103,618,157 (GRCm39) missense probably benign 0.18
R5318:Serpina6 UTSW 12 103,620,221 (GRCm39) missense possibly damaging 0.68
R5350:Serpina6 UTSW 12 103,614,838 (GRCm39) missense possibly damaging 0.68
R5569:Serpina6 UTSW 12 103,620,719 (GRCm39) missense possibly damaging 0.90
R5664:Serpina6 UTSW 12 103,620,726 (GRCm39) missense probably damaging 0.97
R5882:Serpina6 UTSW 12 103,620,494 (GRCm39) missense probably benign 0.00
R6275:Serpina6 UTSW 12 103,614,979 (GRCm39) missense probably benign 0.01
R6364:Serpina6 UTSW 12 103,620,495 (GRCm39) missense probably benign
R7173:Serpina6 UTSW 12 103,613,253 (GRCm39) missense possibly damaging 0.78
R7181:Serpina6 UTSW 12 103,613,203 (GRCm39) missense probably benign 0.00
R7725:Serpina6 UTSW 12 103,614,936 (GRCm39) nonsense probably null
R7811:Serpina6 UTSW 12 103,620,395 (GRCm39) missense probably damaging 1.00
R8418:Serpina6 UTSW 12 103,613,187 (GRCm39) missense probably damaging 0.98
R8770:Serpina6 UTSW 12 103,620,198 (GRCm39) missense probably benign 0.28
R8998:Serpina6 UTSW 12 103,617,988 (GRCm39) missense probably damaging 1.00
R8999:Serpina6 UTSW 12 103,617,988 (GRCm39) missense probably damaging 1.00
Posted On 2013-04-17