Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02271:Nlrp4d'

287123

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Nlrp4d

Ensembl Gene

ENSMUSG00000034122

Gene Name

NLR family, pyrin domain containing 4D

Synonyms

Nalp-beta, Nalp4d

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02271

Quality Score

Status

Chromosome

Chromosomal Location

10092800-10122862 bp(-) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

T to A at 10122625 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182420

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Astn1	C	T	1: 158,338,520 (GRCm39)		probably benign	Het
Bms1	C	A	6: 118,366,290 (GRCm39)	V1068F	probably benign	Het
Cand1	A	T	10: 119,047,626 (GRCm39)	N621K	probably damaging	Het
Cd44	C	T	2: 102,661,732 (GRCm39)	E418K	possibly damaging	Het
Clip2	A	T	5: 134,531,425 (GRCm39)	N758K	probably benign	Het
Cst11	A	T	2: 148,613,161 (GRCm39)	Y55N	probably damaging	Het
Cytip	A	T	2: 58,023,872 (GRCm39)	L316*	probably null	Het
Ddx52	T	C	11: 83,843,057 (GRCm39)	M352T	probably damaging	Het
Fancd2	G	A	6: 113,512,720 (GRCm39)		probably benign	Het
Fat4	A	T	3: 39,034,068 (GRCm39)	E2573D	probably benign	Het
Fbxl13	T	G	5: 21,695,454 (GRCm39)	D646A	probably damaging	Het
Fhdc1	G	A	3: 84,352,042 (GRCm39)	A1061V	possibly damaging	Het
Grid2ip	A	G	5: 143,374,664 (GRCm39)	D928G	probably benign	Het
Hmgxb3	A	G	18: 61,265,285 (GRCm39)	L1231P	probably damaging	Het
Ifitm7	A	G	16: 13,801,541 (GRCm39)	F73L	probably damaging	Het
Ikbkb	T	A	8: 23,155,919 (GRCm39)	T583S	probably benign	Het
Kdm6b	G	A	11: 69,296,893 (GRCm39)	A458V	possibly damaging	Het
Klra2	T	C	6: 131,207,180 (GRCm39)	K143R	probably benign	Het
Kmt2d	A	G	15: 98,764,309 (GRCm39)	S42P	possibly damaging	Het
Krt78	T	A	15: 101,857,028 (GRCm39)	M360L	probably benign	Het
Lamb1	A	G	12: 31,350,250 (GRCm39)	N677S	probably damaging	Het
Lrrc9	G	A	12: 72,557,155 (GRCm39)	V1407I	probably benign	Het
Myo6	A	G	9: 80,168,113 (GRCm39)	T426A	probably benign	Het
Net1	T	C	13: 3,937,663 (GRCm39)	Y146C	probably damaging	Het
Notch4	A	T	17: 34,787,445 (GRCm39)	N335I	probably damaging	Het
Or14j6	A	T	17: 38,215,134 (GRCm39)	E232D	probably benign	Het
Or5ac20	A	T	16: 59,104,584 (GRCm39)	I92K	probably damaging	Het
Or8b53	A	T	9: 38,667,784 (GRCm39)	T267S	probably benign	Het
Pax3	A	T	1: 78,171,969 (GRCm39)	H80Q	probably damaging	Het
Pclo	A	T	5: 14,729,508 (GRCm39)		probably benign	Het
Pdgfra	A	G	5: 75,348,567 (GRCm39)	D869G	probably damaging	Het
Per2	T	C	1: 91,373,332 (GRCm39)	Y152C	probably damaging	Het
Pilrb2	T	C	5: 137,865,125 (GRCm39)	D223G	probably benign	Het
Rag1	T	A	2: 101,473,733 (GRCm39)	I470F	probably damaging	Het
Rap1gap	T	C	4: 137,445,317 (GRCm39)	S333P	probably damaging	Het
Rundc3b	A	G	5: 8,542,530 (GRCm39)	Y430H	probably damaging	Het
Ryr1	T	C	7: 28,793,472 (GRCm39)	D1332G	probably benign	Het
Sgo1	G	A	17: 53,986,567 (GRCm39)	A208V	possibly damaging	Het
Skint5	C	T	4: 113,794,778 (GRCm39)		probably null	Het
Slc26a4	C	T	12: 31,578,853 (GRCm39)		probably benign	Het
Slc28a3	A	T	13: 58,706,451 (GRCm39)	S597T	probably benign	Het
Slc4a5	T	A	6: 83,248,085 (GRCm39)		probably benign	Het
Slc52a3	A	G	2: 151,847,448 (GRCm39)		probably benign	Het
Stac3	A	G	10: 127,339,768 (GRCm39)	D158G	probably benign	Het
Tdo2	T	C	3: 81,871,224 (GRCm39)		probably benign	Het
Usp25	A	T	16: 76,912,335 (GRCm39)	E1018V	probably damaging	Het
Vmn1r46	T	A	6: 89,953,886 (GRCm39)	F245Y	probably damaging	Het

Other mutations in Nlrp4d

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00981:Nlrp4d	APN	7	10,116,021 (GRCm39)	exon	noncoding transcript
IGL01076:Nlrp4d	APN	7	10,106,010 (GRCm39)	missense	unknown	0.00
IGL01656:Nlrp4d	APN	7	10,098,074 (GRCm39)	missense	noncoding transcript
IGL01889:Nlrp4d	APN	7	10,112,261 (GRCm39)	missense	unknown	0.00
IGL02110:Nlrp4d	APN	7	10,116,491 (GRCm39)	exon	noncoding transcript
IGL02637:Nlrp4d	APN	7	10,116,482 (GRCm39)	exon	noncoding transcript
snoop	UTSW	7	10,108,818 (GRCm39)	missense	probably benign	0.02
1mM(1):Nlrp4d	UTSW	7	10,115,640 (GRCm39)	missense	probably benign	0.09
F5493:Nlrp4d	UTSW	7	10,115,011 (GRCm39)	missense	possibly damaging	0.84
IGL03048:Nlrp4d	UTSW	7	10,092,881 (GRCm39)	unclassified	noncoding transcript
R0116:Nlrp4d	UTSW	7	10,108,818 (GRCm39)	missense	probably benign	0.02
R0125:Nlrp4d	UTSW	7	10,116,316 (GRCm39)	missense	probably damaging	1.00
R0390:Nlrp4d	UTSW	7	10,122,705 (GRCm39)	missense	probably benign	0.04
R0452:Nlrp4d	UTSW	7	10,112,219 (GRCm39)	missense	probably benign	0.01
R0595:Nlrp4d	UTSW	7	10,114,972 (GRCm39)	missense	probably benign	0.00
R0729:Nlrp4d	UTSW	7	10,111,612 (GRCm39)	critical splice donor site	probably benign
R0733:Nlrp4d	UTSW	7	10,116,449 (GRCm39)	missense	probably benign	0.02
R1147:Nlrp4d	UTSW	7	10,122,644 (GRCm39)	missense	probably benign	0.00
R1217:Nlrp4d	UTSW	7	10,098,194 (GRCm39)	missense	probably benign	0.36
R1378:Nlrp4d	UTSW	7	10,098,111 (GRCm39)	missense	probably benign	0.23
R1414:Nlrp4d	UTSW	7	10,116,528 (GRCm39)	missense	probably benign	0.22
R1583:Nlrp4d	UTSW	7	10,116,164 (GRCm39)	missense	probably damaging	0.99
R1585:Nlrp4d	UTSW	7	10,116,437 (GRCm39)	missense	probably benign	0.02
R1882:Nlrp4d	UTSW	7	10,116,604 (GRCm39)	critical splice acceptor site	noncoding transcript
R2422:Nlrp4d	UTSW	7	10,096,872 (GRCm39)	missense	probably benign	0.29
R2907:Nlrp4d	UTSW	7	10,112,354 (GRCm39)	missense	probably benign	0.00
R2964:Nlrp4d	UTSW	7	10,112,256 (GRCm39)	nonsense	probably null
R2974:Nlrp4d	UTSW	7	10,112,367 (GRCm39)	critical splice acceptor site	probably benign
R3401:Nlrp4d	UTSW	7	10,096,781 (GRCm39)	missense	probably damaging	1.00
R3402:Nlrp4d	UTSW	7	10,096,781 (GRCm39)	missense	probably damaging	1.00
R4240:Nlrp4d	UTSW	7	10,115,243 (GRCm39)	missense	noncoding transcript
R4682:Nlrp4d	UTSW	7	10,108,879 (GRCm39)	missense	noncoding transcript
R4766:Nlrp4d	UTSW	7	10,096,706 (GRCm39)	critical splice donor site	unknown
R4864:Nlrp4d	UTSW	7	10,115,088 (GRCm39)	missense	noncoding transcript
R4910:Nlrp4d	UTSW	7	10,112,336 (GRCm39)	exon	noncoding transcript
R5307:Nlrp4d	UTSW	7	10,096,709 (GRCm39)	nonsense	probably null
R5596:Nlrp4d	UTSW	7	10,115,951 (GRCm39)	missense	noncoding transcript
R5857:Nlrp4d	UTSW	7	10,116,304 (GRCm39)	missense	noncoding transcript

Posted On

2015-04-16