Incidental Mutation 'IGL02272:Ubxn2b'
ID 287205
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ubxn2b
Ensembl Gene ENSMUSG00000028243
Gene Name UBX domain protein 2B
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.295) question?
Stock # IGL02272
Quality Score
Chromosome 4
Chromosomal Location 6191098-6221688 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 6216071 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 331 (K331N)
Ref Sequence ENSEMBL: ENSMUSP00000029907 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029907]
AlphaFold Q0KL01
Predicted Effect probably damaging
Transcript: ENSMUST00000029907
AA Change: K331N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000029907
Gene: ENSMUSG00000028243
AA Change: K331N

low complexity region 8 25 N/A INTRINSIC
SEP 138 232 3.5e-39 SMART
UBX 251 330 1.05e-8 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre1 T A 17: 57,450,021 (GRCm38) C759* probably null Het
Adgrg6 T A 10: 14,468,829 (GRCm38) M127L probably damaging Het
AI314180 A T 4: 58,811,731 (GRCm38) N1439K probably benign Het
Anxa9 A G 3: 95,305,894 (GRCm38) V47A probably benign Het
Arhgef12 T A 9: 43,001,452 (GRCm38) D483V probably damaging Het
Arrdc3 C A 13: 80,891,650 (GRCm38) probably benign Het
Ccdc169 A G 3: 55,150,748 (GRCm38) E67G probably damaging Het
Ccdc191 T A 16: 43,960,022 (GRCm38) V731D possibly damaging Het
Cdh3 G T 8: 106,547,836 (GRCm38) probably null Het
Cntnap1 G A 11: 101,178,316 (GRCm38) V199M probably damaging Het
Cntnap3 A T 13: 64,757,411 (GRCm38) V852E probably damaging Het
Csmd1 A T 8: 16,199,893 (GRCm38) S1024T probably damaging Het
Cyp3a25 T C 5: 145,993,265 (GRCm38) probably benign Het
Dusp6 T A 10: 99,266,019 (GRCm38) V289D probably damaging Het
Epha6 C T 16: 59,818,937 (GRCm38) R858Q probably damaging Het
Flrt2 T A 12: 95,779,704 (GRCm38) F272Y probably damaging Het
Gbf1 T A 19: 46,269,803 (GRCm38) W846R probably damaging Het
Gtpbp2 T A 17: 46,164,781 (GRCm38) V152E probably benign Het
Hmces A G 6: 87,917,855 (GRCm38) probably null Het
Hsph1 A G 5: 149,617,530 (GRCm38) S852P probably benign Het
Kat6b A C 14: 21,626,778 (GRCm38) K394Q probably damaging Het
Kdr G A 5: 75,961,840 (GRCm38) T475I probably benign Het
Klhl25 A G 7: 75,866,620 (GRCm38) T425A probably benign Het
Klk1b8 T A 7: 43,952,793 (GRCm38) C50S probably damaging Het
Kri1 T C 9: 21,276,168 (GRCm38) Y343C probably damaging Het
Lamb1 T C 12: 31,305,769 (GRCm38) S953P probably benign Het
Lpin1 A G 12: 16,547,600 (GRCm38) V681A probably damaging Het
Lpin3 A G 2: 160,901,661 (GRCm38) T508A probably benign Het
Moxd1 T A 10: 24,282,700 (GRCm38) Y417* probably null Het
Mthfd1l T G 10: 4,041,812 (GRCm38) I588S probably damaging Het
Myo5c C A 9: 75,266,160 (GRCm38) N543K possibly damaging Het
Myo9a T A 9: 59,884,600 (GRCm38) probably benign Het
Nme8 T C 13: 19,658,826 (GRCm38) Y393C probably damaging Het
Nr2e1 T G 10: 42,567,979 (GRCm38) N249T probably damaging Het
Pex11g A G 8: 3,465,898 (GRCm38) V45A probably benign Het
Pkhd1 C A 1: 20,209,260 (GRCm38) G2945W probably damaging Het
Plxnd1 A G 6: 115,993,628 (GRCm38) F393S probably damaging Het
Ppp3cc A G 14: 70,236,489 (GRCm38) V353A probably damaging Het
Prss16 T A 13: 22,003,035 (GRCm38) Q455L probably damaging Het
Ptpn6 A T 6: 124,721,208 (GRCm38) V524E probably damaging Het
Rap1gap A G 4: 137,716,566 (GRCm38) Y163C probably damaging Het
Rnf31 C T 14: 55,598,782 (GRCm38) L598F probably damaging Het
Sardh T G 2: 27,224,991 (GRCm38) D550A probably benign Het
Serpinc1 T G 1: 160,999,992 (GRCm38) I387S probably damaging Het
Sh3d19 A T 3: 86,121,167 (GRCm38) D650V probably benign Het
Sipa1l2 T A 8: 125,492,011 (GRCm38) T196S probably damaging Het
Slc25a46 T C 18: 31,583,568 (GRCm38) T294A probably benign Het
Srrm2 T C 17: 23,815,782 (GRCm38) probably benign Het
Steap2 T A 5: 5,677,612 (GRCm38) N241I probably benign Het
Tcaf3 T C 6: 42,596,660 (GRCm38) Y206C probably damaging Het
Tmem259 T A 10: 79,978,463 (GRCm38) Q322L probably damaging Het
Tnni2 C A 7: 142,443,429 (GRCm38) Q52K possibly damaging Het
Ttn A G 2: 76,735,028 (GRCm38) V28285A possibly damaging Het
Uba7 T A 9: 107,976,153 (GRCm38) S99R probably benign Het
Usp50 G A 2: 126,769,944 (GRCm38) T232I probably damaging Het
Vmn2r116 G A 17: 23,385,999 (GRCm38) M95I probably benign Het
Vmn2r116 T A 17: 23,386,004 (GRCm38) L97Q probably damaging Het
Vmn2r24 A T 6: 123,786,884 (GRCm38) N240I possibly damaging Het
Vmn2r72 T C 7: 85,750,693 (GRCm38) R383G probably benign Het
Other mutations in Ubxn2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01912:Ubxn2b APN 4 6,203,767 (GRCm38) splice site probably null
IGL02096:Ubxn2b APN 4 6,214,749 (GRCm38) missense probably damaging 1.00
R0081:Ubxn2b UTSW 4 6,203,875 (GRCm38) splice site probably benign
R0482:Ubxn2b UTSW 4 6,196,404 (GRCm38) splice site probably null
R1903:Ubxn2b UTSW 4 6,208,889 (GRCm38) missense possibly damaging 0.82
R4206:Ubxn2b UTSW 4 6,204,565 (GRCm38) missense probably damaging 0.99
R5071:Ubxn2b UTSW 4 6,214,746 (GRCm38) missense probably damaging 1.00
R7622:Ubxn2b UTSW 4 6,214,692 (GRCm38) missense probably damaging 0.98
R8034:Ubxn2b UTSW 4 6,191,167 (GRCm38) missense probably benign 0.06
R8836:Ubxn2b UTSW 4 6,216,061 (GRCm38) missense probably damaging 1.00
R9156:Ubxn2b UTSW 4 6,214,646 (GRCm38) missense probably damaging 1.00
R9413:Ubxn2b UTSW 4 6,204,607 (GRCm38) missense probably damaging 1.00
Posted On 2015-04-16