Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00916:Nol10'

28722

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Nol10

Ensembl Gene

ENSMUSG00000061458

Gene Name

nucleolar protein 10

Synonyms

LOC217431

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.965) question?

Stock #

IGL00916

Quality Score

Status

Chromosome

Chromosomal Location

17348458-17430095 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 17361129 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000035930 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046011]

Predicted Effect

probably benign
Transcript: ENSMUST00000046011

SMART Domains

Protein: ENSMUSP00000035930
Gene: ENSMUSG00000061458

Domain	Start	End	E-Value	Type
WD40	42	81	1.1e1	SMART
Blast:WD40	84	123	1e-8	BLAST
WD40	165	204	3.3e1	SMART
WD40	223	257	4.42e1	SMART
WD40	260	299	1.19e1	SMART
WD40	302	340	1.97e2	SMART
low complexity region	451	476	N/A	INTRINSIC
Pfam:NUC153	482	509	1.4e-15	PFAM
low complexity region	515	536	N/A	INTRINSIC
low complexity region	542	553	N/A	INTRINSIC
coiled coil region	557	588	N/A	INTRINSIC
low complexity region	650	660	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aass	T	A	6: 23,075,852	Q762L	probably benign	Het
Aldh1a1	T	C	19: 20,619,997	V114A	probably benign	Het
Ano4	T	C	10: 88,998,098	I459V	probably benign	Het
Atad5	C	T	11: 80,119,000	P1199S	probably damaging	Het
Bmp10	T	C	6: 87,429,160	F43S	possibly damaging	Het
Cd96	T	C	16: 46,041,312	E505G	probably benign	Het
D17Wsu92e	A	G	17: 27,767,919	Y278H	probably damaging	Het
Eapp	T	C	12: 54,692,808	T75A	possibly damaging	Het
Emilin1	T	C	5: 30,913,902	Y10H	probably damaging	Het
Ercc6	A	G	14: 32,562,655		probably benign	Het
Gucy2e	T	C	11: 69,223,097	I1089V	possibly damaging	Het
H6pd	C	A	4: 149,994,468		probably null	Het
Igsf10	A	T	3: 59,331,127	F544L	probably damaging	Het
Il23r	T	C	6: 67,473,931	Y188C	probably damaging	Het
Inpp5j	T	C	11: 3,502,389	E287G	probably damaging	Het
Lrp6	T	C	6: 134,484,289	D735G	probably damaging	Het
Mast2	A	T	4: 116,327,633	M240K	possibly damaging	Het
Mreg	T	A	1: 72,164,132	T96S	probably benign	Het
Mta2	A	T	19: 8,947,101	M220L	probably benign	Het
Mycbp2	A	G	14: 103,291,283		probably benign	Het
Naip2	T	A	13: 100,161,431	N699I	probably damaging	Het
Ncapg	T	G	5: 45,671,192	I95S	probably benign	Het
Ndufa13	A	G	8: 69,894,419		probably benign	Het
Parp8	T	A	13: 116,927,323	I85F	probably damaging	Het
Rgs2	T	A	1: 144,002,229	I78F	probably damaging	Het
Rpia	C	T	6: 70,775,102		probably benign	Het
Sec63	T	C	10: 42,812,457	S488P	possibly damaging	Het
Tfcp2	T	G	15: 100,520,678	H201P	probably damaging	Het
Tnfaip2	T	G	12: 111,453,549	I705R	probably damaging	Het
Ttf1	A	G	2: 29,070,042	N554S	probably benign	Het
Ulk1	A	G	5: 110,793,011	S351P	probably damaging	Het
Zp2	T	A	7: 120,138,174	N264Y	probably damaging	Het

Other mutations in Nol10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1769:Nol10	UTSW	12	17416708	splice site	probably benign
R1884:Nol10	UTSW	12	17368389	critical splice donor site	probably null
R1930:Nol10	UTSW	12	17348554	start codon destroyed	probably null	0.99
R1931:Nol10	UTSW	12	17348554	start codon destroyed	probably null	0.99
R2010:Nol10	UTSW	12	17416101	missense	probably benign	0.00
R2037:Nol10	UTSW	12	17361151	missense	probably benign	0.01
R2168:Nol10	UTSW	12	17373584	missense	probably damaging	1.00
R3729:Nol10	UTSW	12	17424673	missense	probably benign	0.42
R3731:Nol10	UTSW	12	17424673	missense	probably benign	0.42
R4368:Nol10	UTSW	12	17379292	missense	probably damaging	1.00
R4618:Nol10	UTSW	12	17348561	missense	probably damaging	0.98
R4736:Nol10	UTSW	12	17355287	missense	probably damaging	1.00
R5342:Nol10	UTSW	12	17369620	splice site	probably null
R5451:Nol10	UTSW	12	17359102	nonsense	probably null
R5536:Nol10	UTSW	12	17416137	nonsense	probably null
R5586:Nol10	UTSW	12	17416828	missense	possibly damaging	0.73
R6045:Nol10	UTSW	12	17348478	start gained	probably benign
R6833:Nol10	UTSW	12	17352727	missense	probably benign	0.03
R7039:Nol10	UTSW	12	17429184	missense	possibly damaging	0.94
R7189:Nol10	UTSW	12	17373561	critical splice acceptor site	probably null
R7251:Nol10	UTSW	12	17402107	missense	probably damaging	1.00
R7399:Nol10	UTSW	12	17402173	missense	probably damaging	1.00
R7600:Nol10	UTSW	12	17369480	missense	probably damaging	0.99
R7650:Nol10	UTSW	12	17362682	critical splice donor site	probably null
R7729:Nol10	UTSW	12	17424675	missense	possibly damaging	0.62
R7772:Nol10	UTSW	12	17348585	missense	probably damaging	1.00
R7869:Nol10	UTSW	12	17358238	missense	probably null	0.93
R7972:Nol10	UTSW	12	17352647	missense	probably benign	0.15
Z1177:Nol10	UTSW	12	17359088	critical splice acceptor site	probably null

Posted On

2013-04-17