Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02272:Cyp3a25'

287221

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp3a25

Ensembl Gene

ENSMUSG00000029630

Gene Name

cytochrome P450, family 3, subfamily a, polypeptide 25

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL02272

Quality Score

Status

Chromosome

Chromosomal Location

145977194-146009618 bp(-) (GRCm38)

Type of Mutation

intron

DNA Base Change (assembly)

T to C at 145993265 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000123615 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068317] [ENSMUST00000138870] [ENSMUST00000145062]

AlphaFold

O09158

Predicted Effect

probably benign
Transcript: ENSMUST00000068317

SMART Domains

Protein: ENSMUSP00000065585
Gene: ENSMUSG00000029630

Domain	Start	End	E-Value	Type
Pfam:p450	38	493	9.4e-129	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000138870

SMART Domains

Protein: ENSMUSP00000116077
Gene: ENSMUSG00000029630

Domain	Start	End	E-Value	Type
Pfam:p450	38	126	2e-13	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000145062

SMART Domains

Protein: ENSMUSP00000123615
Gene: ENSMUSG00000029630

Domain	Start	End	E-Value	Type
Pfam:p450	38	148	3.9e-21	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153808

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgre1	T	A	17: 57,450,021	C759*	probably null	Het
Adgrg6	T	A	10: 14,468,829	M127L	probably damaging	Het
AI314180	A	T	4: 58,811,731	N1439K	probably benign	Het
Anxa9	A	G	3: 95,305,894	V47A	probably benign	Het
Arhgef12	T	A	9: 43,001,452	D483V	probably damaging	Het
Arrdc3	C	A	13: 80,891,650		probably benign	Het
Ccdc169	A	G	3: 55,150,748	E67G	probably damaging	Het
Ccdc191	T	A	16: 43,960,022	V731D	possibly damaging	Het
Cdh3	G	T	8: 106,547,836		probably null	Het
Cntnap1	G	A	11: 101,178,316	V199M	probably damaging	Het
Cntnap3	A	T	13: 64,757,411	V852E	probably damaging	Het
Csmd1	A	T	8: 16,199,893	S1024T	probably damaging	Het
Dusp6	T	A	10: 99,266,019	V289D	probably damaging	Het
Epha6	C	T	16: 59,818,937	R858Q	probably damaging	Het
Flrt2	T	A	12: 95,779,704	F272Y	probably damaging	Het
Gbf1	T	A	19: 46,269,803	W846R	probably damaging	Het
Gtpbp2	T	A	17: 46,164,781	V152E	probably benign	Het
Hmces	A	G	6: 87,917,855		probably null	Het
Hsph1	A	G	5: 149,617,530	S852P	probably benign	Het
Kat6b	A	C	14: 21,626,778	K394Q	probably damaging	Het
Kdr	G	A	5: 75,961,840	T475I	probably benign	Het
Klhl25	A	G	7: 75,866,620	T425A	probably benign	Het
Klk1b8	T	A	7: 43,952,793	C50S	probably damaging	Het
Kri1	T	C	9: 21,276,168	Y343C	probably damaging	Het
Lamb1	T	C	12: 31,305,769	S953P	probably benign	Het
Lpin1	A	G	12: 16,547,600	V681A	probably damaging	Het
Lpin3	A	G	2: 160,901,661	T508A	probably benign	Het
Moxd1	T	A	10: 24,282,700	Y417*	probably null	Het
Mthfd1l	T	G	10: 4,041,812	I588S	probably damaging	Het
Myo5c	C	A	9: 75,266,160	N543K	possibly damaging	Het
Myo9a	T	A	9: 59,884,600		probably benign	Het
Nme8	T	C	13: 19,658,826	Y393C	probably damaging	Het
Nr2e1	T	G	10: 42,567,979	N249T	probably damaging	Het
Pex11g	A	G	8: 3,465,898	V45A	probably benign	Het
Pkhd1	C	A	1: 20,209,260	G2945W	probably damaging	Het
Plxnd1	A	G	6: 115,993,628	F393S	probably damaging	Het
Ppp3cc	A	G	14: 70,236,489	V353A	probably damaging	Het
Prss16	T	A	13: 22,003,035	Q455L	probably damaging	Het
Ptpn6	A	T	6: 124,721,208	V524E	probably damaging	Het
Rap1gap	A	G	4: 137,716,566	Y163C	probably damaging	Het
Rnf31	C	T	14: 55,598,782	L598F	probably damaging	Het
Sardh	T	G	2: 27,224,991	D550A	probably benign	Het
Serpinc1	T	G	1: 160,999,992	I387S	probably damaging	Het
Sh3d19	A	T	3: 86,121,167	D650V	probably benign	Het
Sipa1l2	T	A	8: 125,492,011	T196S	probably damaging	Het
Slc25a46	T	C	18: 31,583,568	T294A	probably benign	Het
Srrm2	T	C	17: 23,815,782		probably benign	Het
Steap2	T	A	5: 5,677,612	N241I	probably benign	Het
Tcaf3	T	C	6: 42,596,660	Y206C	probably damaging	Het
Tmem259	T	A	10: 79,978,463	Q322L	probably damaging	Het
Tnni2	C	A	7: 142,443,429	Q52K	possibly damaging	Het
Ttn	A	G	2: 76,735,028	V28285A	possibly damaging	Het
Uba7	T	A	9: 107,976,153	S99R	probably benign	Het
Ubxn2b	A	T	4: 6,216,071	K331N	probably damaging	Het
Usp50	G	A	2: 126,769,944	T232I	probably damaging	Het
Vmn2r116	G	A	17: 23,385,999	M95I	probably benign	Het
Vmn2r116	T	A	17: 23,386,004	L97Q	probably damaging	Het
Vmn2r24	A	T	6: 123,786,884	N240I	possibly damaging	Het
Vmn2r72	T	C	7: 85,750,693	R383G	probably benign	Het

Other mutations in Cyp3a25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Cyp3a25	APN	5	146001463	nonsense	probably null
IGL00430:Cyp3a25	APN	5	145993360	missense	probably damaging	1.00
IGL00803:Cyp3a25	APN	5	146001443	splice site	probably benign
IGL00928:Cyp3a25	APN	5	145986954	missense	possibly damaging	0.94
IGL01557:Cyp3a25	APN	5	145984901	missense	probably damaging	1.00
IGL01997:Cyp3a25	APN	5	145994956	missense	possibly damaging	0.92
IGL02140:Cyp3a25	APN	5	146009463	splice site	probably benign
IGL02267:Cyp3a25	APN	5	145998552	missense	possibly damaging	0.48
IGL02327:Cyp3a25	APN	5	145986921	missense	possibly damaging	0.50
IGL02411:Cyp3a25	APN	5	146001447	critical splice donor site	probably benign
IGL02504:Cyp3a25	APN	5	145993331	missense	probably benign	0.03
IGL02653:Cyp3a25	APN	5	146003110	missense	possibly damaging	0.95
R0378:Cyp3a25	UTSW	5	145986842	missense	probably damaging	1.00
R0403:Cyp3a25	UTSW	5	145998513	missense	probably damaging	1.00
R0685:Cyp3a25	UTSW	5	145998546	missense	probably damaging	1.00
R0725:Cyp3a25	UTSW	5	145994936	missense	probably damaging	1.00
R0798:Cyp3a25	UTSW	5	145991533	missense	probably damaging	0.98
R1061:Cyp3a25	UTSW	5	145986833	missense	probably benign
R1519:Cyp3a25	UTSW	5	146001447	critical splice donor site	probably null
R1628:Cyp3a25	UTSW	5	146001463	nonsense	probably null
R1822:Cyp3a25	UTSW	5	145984953	missense	probably damaging	1.00
R1824:Cyp3a25	UTSW	5	145984953	missense	probably damaging	1.00
R1864:Cyp3a25	UTSW	5	145994929	missense	probably damaging	0.98
R2062:Cyp3a25	UTSW	5	145986969	splice site	probably benign
R2401:Cyp3a25	UTSW	5	145986968	critical splice acceptor site	probably null
R2516:Cyp3a25	UTSW	5	146003027	splice site	probably null
R3080:Cyp3a25	UTSW	5	145998531	missense	probably benign	0.33
R3236:Cyp3a25	UTSW	5	146003128	splice site	probably benign
R3694:Cyp3a25	UTSW	5	145989976	splice site	probably null
R3730:Cyp3a25	UTSW	5	146003081	missense	probably damaging	1.00
R4112:Cyp3a25	UTSW	5	146003031	missense	probably benign	0.18
R4258:Cyp3a25	UTSW	5	145991438	missense	probably damaging	1.00
R4651:Cyp3a25	UTSW	5	145994891	missense	probably benign	0.01
R4788:Cyp3a25	UTSW	5	145985082	nonsense	probably null
R4899:Cyp3a25	UTSW	5	145977671	missense	possibly damaging	0.59
R4926:Cyp3a25	UTSW	5	145991456	missense	probably damaging	1.00
R4952:Cyp3a25	UTSW	5	145991524	missense	probably benign	0.01
R5270:Cyp3a25	UTSW	5	145981502	missense	probably benign	0.36
R5595:Cyp3a25	UTSW	5	145994863	critical splice donor site	probably null
R5659:Cyp3a25	UTSW	5	145991546	missense	possibly damaging	0.69
R5787:Cyp3a25	UTSW	5	145998503	missense	probably benign	0.14
R6307:Cyp3a25	UTSW	5	145994956	missense	possibly damaging	0.92
R6380:Cyp3a25	UTSW	5	145998547	missense	probably damaging	0.99
R7055:Cyp3a25	UTSW	5	145992991	missense	probably benign	0.00
R7140:Cyp3a25	UTSW	5	146003045	missense	probably benign
R7189:Cyp3a25	UTSW	5	146003060	missense	probably benign	0.37
R7201:Cyp3a25	UTSW	5	145991447	missense	probably benign	0.22
R7201:Cyp3a25	UTSW	5	146003058	missense	probably benign	0.00
R7332:Cyp3a25	UTSW	5	145993007	missense	probably damaging	1.00
R7404:Cyp3a25	UTSW	5	145986825	missense	probably damaging	1.00
R7548:Cyp3a25	UTSW	5	145986925	missense	probably damaging	0.98
R7607:Cyp3a25	UTSW	5	145984981	missense	possibly damaging	0.87
R8022:Cyp3a25	UTSW	5	145977668	missense	probably benign	0.33
R8266:Cyp3a25	UTSW	5	145992986	missense	probably damaging	1.00
R8894:Cyp3a25	UTSW	5	145994860	splice site	probably benign
R9249:Cyp3a25	UTSW	5	145991546	missense	possibly damaging	0.69
R9588:Cyp3a25	UTSW	5	145984889	missense	probably benign
R9691:Cyp3a25	UTSW	5	145994922	missense	probably benign	0.41
R9694:Cyp3a25	UTSW	5	145986875	nonsense	probably null

Posted On

2015-04-16