Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02273:Gpr135'

287256

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr135

Ensembl Gene

ENSMUSG00000043398

Gene Name

G protein-coupled receptor 135

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.181) question?

Stock #

IGL02273

Quality Score

Status

Chromosome

Chromosomal Location

72114748-72117875 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 72116732 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 345 (I345T)

Ref Sequence

ENSEMBL: ENSMUSP00000058762 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000019862] [ENSMUST00000050649]

AlphaFold

Q7TQP2

Predicted Effect

probably benign
Transcript: ENSMUST00000019862

SMART Domains

Protein: ENSMUSP00000019862
Gene: ENSMUSG00000019718

Domain	Start	End	E-Value	Type
Pfam:Pro_racemase	22	352	8.7e-122	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000050649
AA Change: I345T

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000058762
Gene: ENSMUSG00000043398
AA Change: I345T

Domain	Start	End	E-Value	Type
low complexity region	26	44	N/A	INTRINSIC
low complexity region	65	88	N/A	INTRINSIC
Pfam:7tm_1	89	350	7.5e-43	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930451I11Rik	T	C	7: 126,429,931 (GRCm39)	T89A	probably benign	Het
Amhr2	T	C	15: 102,360,924 (GRCm39)	V353A	probably benign	Het
Bbox1	A	T	2: 110,105,961 (GRCm39)	Y194*	probably null	Het
Bltp1	T	A	3: 36,975,586 (GRCm39)		probably benign	Het
Bnipl	C	A	3: 95,153,086 (GRCm39)	R131L	possibly damaging	Het
Casp8ap2	T	C	4: 32,643,974 (GRCm39)	S1016P	probably damaging	Het
Cblb	A	G	16: 51,867,657 (GRCm39)	I88M	possibly damaging	Het
Cyp24a1	A	T	2: 170,338,278 (GRCm39)	Y89N	probably damaging	Het
Ddx25	G	T	9: 35,458,122 (GRCm39)	N332K	possibly damaging	Het
Dnaaf5	C	T	5: 139,163,671 (GRCm39)	Q348*	probably null	Het
Dnah3	A	T	7: 119,550,494 (GRCm39)	I3264N	probably damaging	Het
Eml4	T	A	17: 83,763,808 (GRCm39)		probably null	Het
Farsa	C	T	8: 85,594,455 (GRCm39)	A368V	probably damaging	Het
Fat1	T	C	8: 45,403,368 (GRCm39)	Y40H	probably damaging	Het
Glt1d1	T	A	5: 127,734,208 (GRCm39)		probably benign	Het
Gm5422	A	G	10: 31,126,003 (GRCm39)		noncoding transcript	Het
Hmcn2	G	A	2: 31,314,389 (GRCm39)	V3616I	probably benign	Het
Kif9	A	T	9: 110,339,538 (GRCm39)	K460M	probably damaging	Het
Ldhd	T	C	8: 112,353,922 (GRCm39)	E426G	probably benign	Het
Mdh1	A	T	11: 21,509,786 (GRCm39)	N196K	probably benign	Het
Nfkb1	A	T	3: 135,310,968 (GRCm39)	C444S	probably benign	Het
Pfkfb2	G	A	1: 130,635,319 (GRCm39)	R81C	probably damaging	Het
Pfpl	T	C	19: 12,407,327 (GRCm39)	V526A	possibly damaging	Het
Phf20l1	T	A	15: 66,511,874 (GRCm39)	V951E	probably damaging	Het
Pik3cg	A	T	12: 32,226,809 (GRCm39)	L1026Q	probably damaging	Het
Pms1	T	C	1: 53,247,156 (GRCm39)	N263S	probably damaging	Het
Prkcb	T	A	7: 122,226,990 (GRCm39)	F659I	probably damaging	Het
Prr14	A	G	7: 127,075,108 (GRCm39)	I69M	probably damaging	Het
Rita1	C	T	5: 120,747,858 (GRCm39)	A147T	probably damaging	Het
Senp5	T	C	16: 31,808,690 (GRCm39)	H161R	probably benign	Het
Spc25	A	G	2: 69,035,273 (GRCm39)		probably benign	Het
Spty2d1	A	G	7: 46,647,321 (GRCm39)	V536A	probably damaging	Het
Susd2	A	G	10: 75,476,772 (GRCm39)	S84P	possibly damaging	Het
Tacc1	A	C	8: 25,649,797 (GRCm39)	L768V	probably damaging	Het
Tbpl2	A	T	2: 23,986,531 (GRCm39)	I5N	probably benign	Het
Tmc2	A	G	2: 130,071,126 (GRCm39)	D285G	probably damaging	Het
Tns3	A	T	11: 8,384,531 (GRCm39)	V1429E	probably damaging	Het
Trmt44	T	C	5: 35,731,457 (GRCm39)	Y190C	probably damaging	Het
Ubr4	G	A	4: 139,199,889 (GRCm39)	R4591H	possibly damaging	Het
Zfc3h1	T	A	10: 115,263,004 (GRCm39)	D1739E	probably benign	Het
Zfp26	A	G	9: 20,352,744 (GRCm39)	V107A	probably damaging	Het

Other mutations in Gpr135

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01458:Gpr135	APN	12	72,116,442 (GRCm39)	missense	probably benign
IGL02059:Gpr135	APN	12	72,116,858 (GRCm39)	missense	possibly damaging	0.87
IGL02219:Gpr135	APN	12	72,117,047 (GRCm39)	missense	probably damaging	1.00
R4688:Gpr135	UTSW	12	72,117,720 (GRCm39)	missense	probably benign
R4791:Gpr135	UTSW	12	72,116,642 (GRCm39)	missense	probably benign	0.12
R5001:Gpr135	UTSW	12	72,117,282 (GRCm39)	missense	probably benign	0.10
R5811:Gpr135	UTSW	12	72,116,641 (GRCm39)	missense	possibly damaging	0.87
R5857:Gpr135	UTSW	12	72,117,614 (GRCm39)	missense	probably benign	0.25
R7604:Gpr135	UTSW	12	72,116,641 (GRCm39)	missense	possibly damaging	0.87
R7708:Gpr135	UTSW	12	72,116,733 (GRCm39)	missense	probably benign	0.06
R9367:Gpr135	UTSW	12	72,117,473 (GRCm39)	missense	possibly damaging	0.95

Posted On

2015-04-16